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The use of mucoadhesive polymers to enhance the hypotensive effect of a melatonin analogue, 5-MCA-NAT, in rabbit eyes.
Andrés-Guerrero Vanessa, Molina-Martínez Irene T, Peral Assumpta, de las Heras Beatriz, Pintor Jesús, Herrero-Vanrell Rocío
Invest Ophthalmol Vis SciMar 201114 citationsBasic Science
This study found bioadhesive polymers significantly enhanced the IOP-lowering effect and duration of a melatonin analogue (5-MCA-NAT) in rabbits, offering a promising, well-tolerated strategy for glaucoma treatment.