Mingguang He

Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs.

A deep learning system can detect referable GON with high sensitivity and specificity.

Incidence of and Factors Associated With Myopia and High Myopia in Chinese Children, Based on Refraction Without Cycloplegia.

The incidence of myopia among Chinese students based on refraction without cycloplegia is among the highest of any cultural or ethnic group.

Visualizing Deep Learning Models for the Detection of Referable Diabetic Retinopathy and Glaucoma.

These findings suggest that this visualization method can highlight traditional regions in disease diagnosis, substantiating the validity of the deep learning models investigated. This visualization technique may promote the clinical adoption of these models.

A Comparison of Perimetric Results from a Tablet Perimeter and Humphrey Field Analyzer in Glaucoma Patients.

The perimetry results from the MRF have a strong correlation to the HFA outcomes. MRF also has test-retest reliability comparable to HFA.

Six-month Longitudinal Comparison of a Portable Tablet Perimeter With the Humphrey Field Analyzer.

MRF correlated strongly with HFA across 4 visits over a 6-month period, and has good test-retest reliability. MRF is suitable for monitoring visual fields in settings where conventional perimetry is not readily accessible.

Ocular Biometric Risk Factors for Progression of Primary Angle Closure Disease: The Zhongshan Angle Closure Prevention Trial.

Ocular biometric measurements can help to risk-stratify patients with early angle closure for more severe disease.

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.

A range of different MR analysis methods provided evidence, in general, that the causal effect of BP on IOP (and POAG) was modest, or even zero.

Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography.

Both devices had generally good agreement. However, there were proportional and constant biases in most angle parameters. Thus, it is not recommended that values be used interchangeably.

Anatomic Changes and Predictors of Angle Widening after Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial.

Superior LPI location results in significantly greater angle widening compared with temporal or nasal locations in a Chinese population with PACS. This supports consideration of superior LPI locations to optimize anatomic changes after LPI.

Visual field defect classification in the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Registry Study.

A proposed combined visual field classification for high myopia and glaucoma demonstrates acceptable intergrader agreement.

Visual Impairment and Major Eye Diseases in Chronic Kidney Disease: The National Health and Nutrition Examination Survey, 2005-2008.

This nationally representative sample of the US population demonstrated high prevalence and strong associations of VI and major eye diseases with CKD, highlighting the importance of ocular screening among CKD patients and potential common pathogenesis…

Residual Angle Closure One Year After Laser Peripheral Iridotomy in Primary Angle Closure Suspects.

One year after LPI, >80% of PACS had gonioscopic residual angle closure. Greater baseline iris volume and higher IOP at baseline are independent risk factors for residual gonioscopic angle closure.

Fourteen-Year Outcome of Angle-Closure Prevention with Laser Iridotomy in the Zhongshan Angle-Closure Prevention Study: Extended Follow-up of a Randomized Controlled Trial.

During the 14 years, 390 LPI-treated eyes and 388 control eyes were lost to follow-up.

Predictors of intraocular pressure change after phacoemulsification in patients with pseudoexfoliation syndrome.

Non-glaucomatous patients with PXS experience moderate IOP reduction following phacoemulsification, and this effect is correlated with preoperative IOP, aspiration time and infusion fluid used intraoperatively.

Comparison of Anterior Segment Optical Coherence Tomography Parameters Among Vietnamese, Chinese, and Whites.

Vietnamese subjects had more of the anatomic characteristics associated with risk for angle closure, including small anterior chamber dimension, high iris curvature, and high lens vault, compared to the other 2 ethnicities.

Anterior Segment Dimensions Following Laser Iridotomy in Acute Primary Angle Closure and Fellow Eyes.

In APAC eyes and their fellow eyes, LPI resulted in significant anterior chamber angle widening and increased anterior chamber area.

Biometric Risk Factors for Angle Closure Progression After Laser Peripheral Iridotomy.

Study results suggest that persistent angle narrowing detected by AS-OCT or cumulative gonioscopy score was predictive of disease progression in PACS eyes after LPI.

In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study.

Compared with ciliary sulcus secondary IOL implantation, in-the-bag IOL implantation reduced AEs and yielded better IOL centration and BCVA for pediatric aphakia.

Associations of Vision Impairment and Eye Diseases With Memory Decline Over 4 Years in China and the United States.

Distance vision impairment was independently associated with an accelerated rate of memory decline in both China and the United States.

Evaluation of the Diagnostic Performance of Swept-Source Anterior Segment Optical Coherence Tomography in Primary Angle Closure Disease.

SS-OCT of the anterior segment showed excellent diagnostic performance distinguishing PACD from normal eyes and moderate diagnostic ability distinguishing eyes with PAC/PACG from eyes with PACS.

Anterior Segment Parameters of Filipino-Americans Compared to Chinese-Americans and Caucasian Americans Using Anterior Segment Optical Coherence Tomography.

Filipinos appear to have more convex and thicker irises, smaller lens vault and narrower angles compared to Caucasians. Filipino eyes closely resembled Chinese eyes with similar iris and angle parameters.

Achieving Inner Aqueous Drain in Glaucoma Secondary to Iridocorneal Endothelial Syndrome: One Year Results of Penetrating Canaloplasty.

Penetrating canaloplasty rescued the inner aqueous outflow in ICE eyes and demonstrated acceptable success in IOP control with few complications, providing a new option for the management of GS-ICE.

Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety.

Our study enhances the existing epidemiological evidence and underscores the polygenic overlap between glaucoma and mental traits. This observation suggests a correlation shaped by pleiotropic genetic variants rather than being indicative of direct causal relationships.

Bridging the Camera Domain Gap With Image-to-Image Translation Improves Glaucoma Diagnosis.

Image-to-image translation across cameras can be achieved by using GAN to solve the problem of disc overexposure in Optain cameras.

How Does Cataract Surgery Rate Affect Angle-closure Prevalence.

Our study indicated that with CSR increased, the OA prevalence could decrease remarkably especially in the older population.

Real-world assessment of topical glaucoma medication persistence rates based on national pharmaceutical claim data in a defined population.

Our data has shown a medium level of persistence to topical glaucoma medication among middle-aged and older Australian adults. However, efforts are still needed to improve the rate of persistence.

Corneal Configurations and High-order Aberrations in Primary Congenital Glaucoma.

Abnormal corneal irregularity and HOAs are common in PCG eyes, even in those with limited optic nerve damage. These abnormalities relate to compromised visual outcomes.

Comparison of Anterior Chamber Parameters in Patients With Plateau Iris Configuration and Pupillary Block Using ASOCT.

ASOCT parameters are not significantly different between PB and PIC eyes. PIC eyes may have greater IT at its base.

Deep Learning Classification of Angle Closure based on Anterior Segment OCT.

Convolutional neural network classifiers can effectively distinguish PACD from controls on AS-OCT with good generalizability across different patient cohorts. However, their performance is moderate when trying to distinguish PACS versus PAC + PACG.

The Impact of Pharmacological Dilation on Intraocular Pressure in Primary Angle Closure Suspects.

Postdilation IOP elevation was similar among treated and untreated eyes, and the risk of developing AAC was very low, even among patients with PACS.

Acute Angle-Closure Attacks Are Uncommon in Primary Angle-Closure Suspects after Pharmacologic Mydriasis: The Zhongshan Angle-Closure Prevention Trial.

The risk of incident AAC attacks in PACSs was extremely low, even in a higher-risk group that underwent repeated pharmacologic pupillary dilation over 6 years of follow-up.

Long-Term Prediction and Risk Factors for Incident Visual Field Defect in Nonpathologic High Myopia.

The development of VFD occurred frequently in individuals with nonpathologic HM and can be effectively predicted using relevant metrics. The findings will aid in expanding our knowledge of optic neuropathy in HM.

Efficacy and safety of penetrating canaloplasty versus ab externo canaloplasty for primary open-angle glaucoma: A randomized controlled trial.

Compared to ab externo canaloplasty, penetrating canaloplasty had a greater surgical success rate and better IOP reduction with a comparable rate of complications.

Long-Term Risk and Prediction of Progression in Primary Angle Closure Suspect.

This cohort study suggests that higher IOP, shallower central and limbal ACDs, and smaller TISA at 500 μm and light-room ARA at 750 μm may serve as baseline predictors for progression to PAC in PACS eyes.

Ten-year changes of intraocular pressure in adults: the Liwan Eye Study.

We observed a small increase in IOP over 10 years in this adult Chinese population, which was positively related to the longitudinal change in BMI.

Short-Term Ocular Biometric Changes as Predictors of Long-Term Angle Closure Progression.

Short-term (18-month) changes in LV and TISA750 were associated with long-term (36-72 month) angle closure progression in untreated PACS eyes, suggesting that monitoring changes in lens size or position and angle width could augment predictive…

Role of Static and Dynamic Ocular Biometrics Measured in the Dark and Light as Risk Factors for Angle Closure Progression.

Static parameters measured in the light are as predictive, and possibly more so, of angle closure progression as those measured in the dark.

Population-Based Utility of van Herick Grading for Angle-Closure Detection.

Comparison of Anterior Segment Parameters among Koreans, Chinese, and White Persons.

The Korean cohort demonstrated smaller average LV and relative LV.

Use of antihypertensive medications and the risk of glaucoma onset: Findings from the 45 and Up Study.

This study indicated that the use of antihypertensive medications was not associated with glaucoma onset. Decreased risks of glaucoma onset in users of BBA and diuretics require further validation.

Two Decades of Angle-Closure Glaucoma Research.

These offer clinicians a range of potent tools to deliver improved outcomes for their patients with and persons at risk for PACD.

Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes.

This longitudinal study suggested that baseline RNFL, GCIPL, GCC, INL, and PS thickness were significant predictors for the incidence of glaucoma among myopic participants, which indicated a pattern of internal layer thinning (except INL) and…

Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study.

Our study demonstrated the associations of static and dynamic iris parameters in healthy Chinese individuals. The findings provided a possible explanation for the higher prevalence of primary angle closure disease in elderly and female populations.

Diagnosing glaucoma in primary eye care and the role of Artificial Intelligence applications for reducing the prevalence of undetected glaucoma in Australia.

Despite its potential, there are significant barriers and challenges to address before AI can be deployed in primary healthcare settings, including external validation, high quality real-world implementation, protection of privacy and cybersecurity, and medico-legal implications.

Higher intraocular pressure is associated with slower axial growth in children with non-pathological high myopia.

Higher IOP is associated with slower rather than faster axial growth in children with non-pathological high myopia, an association plausibly confounded by the increased influence of ocular compliance on IOP.

Iris volume change with physiologic mydriasis to identify development of angle closure: the Zhongshan Angle Closure Prevention Trial.

A smaller change in ΔVOL is an additive risk factor to identify eyes more likely to develop angle closure disease.

Changes in Anterior Segment Morphology After Laser Peripheral Iridotomy in Acute Primary Angle Closure.

This study confirms that LPI results in a significant increase in the angle width, ACD, and ACA as well as flattening of the iris in APAC eyes.

Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes.

Ocular biometric parameters can differentiate phacomorphic angle closure from APAC eyes. Shallower ACD and greater LV, axial length, and ACA are the main parameters that distinguish phacomorphic angle closure from APAC.

Association of ocular conditions with narrow angles in different ethnicities.

Despite ethnic differences in ACA, ACV, ACW, LV, IT, and IArea, the same 3 anterior segment parameters (ACA, ACV, and LV) were the strongest predictors of angle width (TISA750 and AOD750) in all 4 ethnic…

Does Myopia Affect Angle Closure Prevalence.

The increasing prevalence of myopia has minimal impact on the prevalence of OA.

Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects.

Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses.