Nishida Takashi

Performances of Machine Learning in Detecting Glaucoma Using Fundus and Retinal Optical Coherence Tomography Images: A Meta-Analysis.

Performance of ML in detecting glaucoma compares favorably to that of experts and is promising for clinical application. Future prospective studies are needed to better evaluate its real-world utility.

Impact of Smoking on Visual Field Progression in a Long-term Clinical Follow-up.

Heavy smokers are more likely to sustain VF loss in eyes with glaucoma.

Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma.

The findings of this cohort study suggest that faster vessel density loss during an initial follow-up period was associated with faster concurrent and subsequent rates of visual field loss during an extended period.

Association of Intraocular Pressure With Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma.

In this study, intraocular pressure variability was independently associated with structural change in patients with glaucoma, even after adjustment for mean intraocular pressure, supporting its potential value in clinical management.

Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements.

The proposed CNNmodel improved the estimation of 10-2 VF map based on circumpapillary SD-OCT RNFL thickness measurements.

Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.

Longitudinal OCTA measurements complement OCT-derived structural metrics for the evaluation of functional VF loss in patients with glaucoma.

Macular Thickness and Microvasculature Loss in Glaucoma Suspect Eyes.

Whereas the rate of GCC thinning was faster on average in suspect eyes than in healthy eyes, some suspect eyes showed significant loss of vessel density and faster vessel density loss than GCC thinning.

Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric Glaucoma Patients.

These findings suggest that patients with perimetric and preperimetric glaucoma have worse VRQOL than patients with healthy eyes.

Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.

Lower macular SVD, and not DVD, was associated with a higher probability of past VF progression.

Association Between Rate of Ganglion Cell Complex Thinning and Rate of Central Visual Field Loss.

In this cohort study, rapid GCC thinning during an initial follow-up period was associated with faster rates of central visual field decline.

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor of Central Visual Field Progression in Glaucoma.

Lower CH was associated with a statistically significant, but relatively small, increased risk of central VF progression on the 10-2 test grid.

Association of Rates of Ganglion Cell and Inner Plexiform Thinning With Development of Glaucoma in Eyes With Suspected Glaucoma.

This study found that faster rates of GCIPL and cpRNFL thinning were associated with higher risks of developing perimetric glaucoma.

Perimetric Comparison Between the IMOvifa and Humphrey Field Analyzer.

In this cross-sectional study, 138 eyes (including 25 healthy, 48 glaucoma suspects, and 65 primary open angle glaucoma) of 69 patients were evaluated.

Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma.

Smoking intensity is associated with reduced optic nerve vessel density in glaucoma.

Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage.

Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location.

Rate of Initial Optic Nerve Head Capillary Density Loss and Risk of Visual Field Progression.

Rapid initial optic nerve head capillary density loss from OCTA was associated with a faster rate of visual field progression and a doubling of the risk of developing event progression in this study.

Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma.

Rates of MvD area and angular circumference change over time were associated with concurrent rates of cpRNFL loss in POAG eyes.

Longitudinal Structure-Function Relationship between Macular Vessel Density and Thickness and Central Visual Field in Early Glaucoma.

Rates of VD loss and GCC thinning are associated with central VF loss over time. Assessment of both macular VD and GCC thickness should be considered for evaluation of glaucoma progression.

Measurements of OCT Angiography Complement OCT for Diagnosing Early Primary Open-Angle Glaucoma.

Associations between capillary density and visual function were found in the regions known to be at highest risk for damage in preperimetric glaucoma eyes and all regions of mild glaucoma eyes.

Retinal Nerve Fiber Layer Optical Texture Analysis and 10-2 Visual Field Assessment in Glaucoma.

Papillomacular and papillofoveal RNFL bundle defects are present in a considerable proportion of eyes with glaucoma.

Performance of ChatGPT on Responding to Common Online Questions Regarding Key Information Gaps in Glaucoma.

Progressive Visual Field Loss and Subsequent Quality of Life Outcomes in Glaucoma.

Baseline severity and initial rates of change of VF damage are associated with QOL outcomes over an extended follow-up.

Racial Differences in Detection of Glaucoma Using Retinal Nerve Fiber Layer Thickness and Bruch Membrane Opening Minimum Rim Width.

RNFLT and BMO-MRW had consistently lower diagnostic performance in AD individuals compared with ED individuals.

Effect of Testing Frequency on the Time to Detect Glaucoma Progression With Optical Coherence Tomography (OCT) and OCT Angiography.

The time required to detect a statistically significant negative cpRNFL and cpCD slope decreased as the testing frequency increased, albeit not proportionally.

Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers.

After ≥25 years of smoking cessation, the risk of VF progression in former heavy smokers becomes similar to never smokers. Long-term smoking cessation may be associated with lower VF progression in glaucoma patients.

Long-Term Blood Pressure Variability and Visual Field Progression in Glaucoma.

In this cohort study, higher mean blood pressure and higher SD of blood pressure were associated with faster VF progression.

Time to Glaucoma Progression Detection by Optical Coherence Tomography in Individuals of African and European Descents.

Time to progression detection was similar for both races when assuming identical RNFLT baseline/thinning rates, and shorter in AD eyes under real-world simulation when AD had faster RNFLT thinning.

Clinical Factors Associated With Long-Term OCT Variability in Glaucoma.

Relevant clinical factors affecting long-term RNFLT variability in glaucoma were identified.

Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma.

These findings suggest that faster and sectoral central location of ganglion cell complex thinning provides useful information in determining the risk of vision-related quality of life in glaucoma.

Relationship of Choroidal Microvasculature Dropout and Beta Zone Parapapillary Area With Visual Field Changes in Glaucoma.

MvD area rates, but not β-PPA area rates, were associated with VF MD loss changes in eyes with POAG.

Rates of Circumpapillary Retinal Nerve Fiber Layer Thinning and Capillary Density Loss in Glaucomatous Eyes with Disc Hemorrhage.

Mean rates of vessel density loss between DH and non-DH eyes were different not only in the affected area but also in the other regions.

Time to Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field in Glaucoma Individuals of African Descent.

Computer simulation showed a potentially shorter time to detect RNFLT progression than VF MD progression in eyes from individuals of AD.

Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.

DL models enable the estimation of VF loss from OCTA images with high accuracy.

Longitudinal OCTA vessel density loss in macula and optic nerve head in healthy, glaucoma suspect and established glaucoma eyes.

In glaucoma, there is earlier microvasculature loss in the ONH than in the macula.

Association Between Longitudinal 10-2 Central Visual Field Change and the Risk of Visual Acuity Loss in Mild-to-Moderate Glaucoma.

Faster 10-2 VF MD and hemifield MS worsening are associated with the development of VA loss. Monitoring the longitudinal central 10-degree VF change may suggest that there is impending VA impairment in glaucoma.

Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma.

Central VF change had a greater impact on VRQOL compared to global VF change.

Optic Disc Size and Circumpapillary Retinal Nerve Fiber Layer Thinning in Glaucoma.

Larger optic disc size is associated with faster cpRNFL thinning in glaucoma, independent of race.

Association of Long-Term Intraocular Pressure Variability and Rate of Ganglion Complex Thinning in Patients With Glaucoma.

IOP variability showed an independent association with macular change in patients with glaucoma regardless of severity at baseline, even after adjustment for mean IOP, supporting its potential value as a therapeutic target for clinical decision-making.

Smoking Intensity is Associated With Progressive Optic Nerve Head Vessel Density Loss in Glaucoma.

A history of greater smoking consumption was associated with faster vessel density loss, suggesting smoking intensity as a potential risk factor for glaucoma.

Racial Differences in the Diagnostic Accuracy of OCT Angiography Macular Vessel Density for Glaucoma.

Diagnostic performance of OCTA macular VD, but not GCC thickness, for glaucoma detection varies by race.

Effect of Corneal Hysteresis on the Rates of Microvasculature Loss in Glaucoma.

Lower CH values were significantly associated with faster rates of wiCD loss over time.

OCT-Angiography Face Mask-Associated Artifacts During the COVID-19 Pandemic.

Face mask wearing had no significant effect on area of artifacts or vessel density measurements. OCT-A vessel density measurements can be acquired reliably with face mask wear during the pandemic.

Rates of Retinal Nerve Fiber Layer Thinning in Distinct Glaucomatous Optic Disc Phenotypes in Early Glaucoma.

Rates of cpRNFL thinning were different among the 4 glaucomatous optic disc phenotypes.

Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma.

ROTA uncovers a wide spectrum of RNFL bundle defects spanning the entire glaucoma continuum.

Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.

MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia.

Impact of Physical Activity Levels on Visual Field Progression in Individuals With Glaucoma.

Higher PA amounts are an independent predictor of a slower rate of VF MD loss. Further research is needed to explore whether increased PA protects against glaucoma progression.

Short-Term Rates of Visual Field Change Predict Glaucoma Progression.

The initial 2-year rate of VF MD change predicts subsequent progression events based on FDA-consistent criteria in both early and moderate-to-advanced glaucoma eyes.

Rates of Choriocapillaris Microvascular Dropout and Macular Structural Changes in Glaucomatous Optic Neuropathy With and Without Myopia.

Rates of GCIPL thinning were associated with rates of MvD area and angular circumference change over time in myopic POAG eyes.

Glaucoma Progression Detection Time Using OCT and OCTA in African and European Descendants.

Using computer simulation, there was no racial difference in OCT and OCTA time to progression detection between AD and ED.

Proportion of Fast Progressors in the Central versus Global Visual Field Across Varying Glaucoma Severity Groups.

Selective analysis of the MTDdetected a greater proportion of eyes that exhibited fast progression across all disease severity groups compared to measurements from the entire VF, underscoring the importance of close monitoring for progressive central…

Predicting Perimetric Glaucoma Development in Suspects Using Widefield OCT-Based Risk Scores.

Baseline OCT-based risk scores from a single wide scan, incorporating both peripapillary RNFL and macular thickness measurements, are associated with the subsequent development of perimetric glaucoma development in glaucoma suspect eyes, offering valuable insights for…

Comparison of Methods for Visual Field Progression in Eyes With Central Visual Field Defects.

Agreement among methods for central VF progression monitoring is low to moderate. Concordance between 24-2 and 10-2 VF methods is variable, with 10-2 detecting a higher proportion of central progression.

Deep Learning Estimation of 24-2 Visual Field Map From Optic Nerve Head Optical Coherence Tomography Angiography.

DL models from OCTA images demonstrated high accuracy in estimating 24-2 VF maps by leveraging information from ONH layers.

Initial circumpapillary retinal nerve fibre layer rates of change predict glaucomatous progression.

The rate of initial cpRNFL change observed within half the monitoring period may effectively predict the subsequent structural progression and can be used by clinicians to predict the course of glaucoma when monitoring patients.

Association Between Optic Nerve Head Prelaminar Schisis and Visual Field Progression in Glaucoma.

The presence and severity of severe prelaminar schisis were associated with faster VF progression, suggesting its potential as a biomarker to identify patients at higher risk of progression and to guide clinical management in glaucoma.

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Increasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year.

Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma.

Horizontal gaze, especially in adduction, significantly reduces visual sensitivity in glaucoma, suggesting a specific vulnerability associated with eye movement.

Rates of Visual Field Progression Before and After the Onset of Atrial Fibrillation.

The presence of atrial fibrillation and related microvascular damage might accelerate visual field loss.

Optic Disc Structural Progression in Glaucoma Suspect Eyes with Microvascular Dropout.

In glaucoma suspect eyes, the presence of both MvD and β-zone PPA progression were independently associated with structural optic disc progression.

Original vs Shoji Edition of Tanito Microhook Trabeculotomy Combined with Cataract Surgery: Comparative Clinical Outcomes.

Both versions of TMH trabeculotomy combined with cataract surgery demonstrated acceptable mid-term surgical success and safety profiles. The Shoji edition, designed to improve access and usability, may offer advantages in certain surgical settings.

Association between metformin use with circumpapillary retinal nerve fibre layer thickness and capillary vessel density in glaucoma.

Metformin use was associated with higher wiCD and thicker cpRNFL.

Detection of glaucoma progression on longitudinal series of en-face macular optical coherence tomography angiography images with a deep learning model.

The optimised DL model detected glaucoma progression based on longitudinal macular OCTA images showed good performance. With external validation, it could enhance detection of glaucoma progression.

Association of foveal avascular zone change and glaucoma progression.

Significant FAZ increase was weakly associated with moderately faster rates of both GCC thinning and VF MD loss, but not macular vessel density change in glaucoma eyes.

Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.

Although some predictors were identified, long-term RNFLT variability appeared small for both AD and ED eyes.

Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression.

OCT and OCTA showed limited agreement on event-based progression detection, with OCT showing better agreement with VF.

Progression to Legal Blindness in Patients With Normal Tension Glaucoma: Hospital-Based Study.

The probability of blindness in eyes with NTG is much lower than previously reported in patients with high-tension glaucoma.