Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.

PRCIS

Larger choriocapillaris microvasculature dropout area and wider angular circumference are significantly associated with 24-2C central visual field damage in primary open angle glaucoma eyes with and without axial myopia.

PURPOSE

To evaluate the relationship between a juxtapapillary choriocapillaris microvasculature dropout (MvD) and central visual field (VF) damage in primary open angle glaucoma (POAG) patients with or without axial myopia.

METHODS

This cross-sectional study included 125 patients with POAG or glaucoma suspects stratified into no axial myopia (axial length (AL) ≤24 mm; 46 eyes), mild axial myopia (24 mm 26 mm; 59 eyes). Presence, area, and angular circumference of juxtapapillary MvD were evaluated on OCT-A en-face choroidal images and B-scans. Perimetry was conducted using the 24-2C and 10-2 Humphrey program.

RESULTS

Mean 24-2C VF mean deviation was significantly worse in eyes with MvD compared with eyes without MvD across all groups (all P <0.042). Central VF defects detected in the 24-2C and 10-2 VF tests were significantly more prevalent among eyes with MvD (68.3% and 81.7%, respectively) compared with eyes without MvD (19.0% and 38.1%, respectively) ( P <0.001) in the mild axial myopia group. In multivariable analysis, larger MvD area ( P =0.014) and wider MvD angular circumference ( P =0.006) were significantly associated with higher likelihood of the presence of 24-2C central VF damage in overall cohort.

CONCLUSIONS

MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia. Choriocapillaris MvD assessment shows promise for identifying POAG patients with a higher risk of having central VF defects and may provide clinical insights into the pathogenesis of glaucoma in myopia.