Walker Evan

Association of Intraocular Pressure With Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma.

In this study, intraocular pressure variability was independently associated with structural change in patients with glaucoma, even after adjustment for mean intraocular pressure, supporting its potential value in clinical management.

Deep Learning Identifies High-Quality Fundus Photographs and Increases Accuracy in Automated Primary Open Angle Glaucoma Detection.

The DL quality model was able to accurately assess fundus photograph quality. Using automated quality assessment to filter out low-quality photographs increased the accuracy of a DL POAG detection model.

Association of Rates of Ganglion Cell and Inner Plexiform Thinning With Development of Glaucoma in Eyes With Suspected Glaucoma.

This study found that faster rates of GCIPL and cpRNFL thinning were associated with higher risks of developing perimetric glaucoma.

A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design.

Our deep learning models were able to accurately estimate both macula GCIPL and ONH RNFL hemiretinal thickness.

Diagnostic Accuracy of Optic Nerve Head and Macula OCT Parameters for Detecting Glaucoma in Eyes With and Without High Axial Myopia.

The diagnostic accuracy for pRNFL and GCIPL was high for high axial myopic eyes and shows promise for glaucoma detection in high myopes.

Racial Differences in Detection of Glaucoma Using Retinal Nerve Fiber Layer Thickness and Bruch Membrane Opening Minimum Rim Width.

RNFLT and BMO-MRW had consistently lower diagnostic performance in AD individuals compared with ED individuals.

Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers.

After ≥25 years of smoking cessation, the risk of VF progression in former heavy smokers becomes similar to never smokers. Long-term smoking cessation may be associated with lower VF progression in glaucoma patients.

Time to Glaucoma Progression Detection by Optical Coherence Tomography in Individuals of African and European Descents.

Time to progression detection was similar for both races when assuming identical RNFLT baseline/thinning rates, and shorter in AD eyes under real-world simulation when AD had faster RNFLT thinning.

Clinical Factors Associated With Long-Term OCT Variability in Glaucoma.

Relevant clinical factors affecting long-term RNFLT variability in glaucoma were identified.

Time to Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field in Glaucoma Individuals of African Descent.

Computer simulation showed a potentially shorter time to detect RNFLT progression than VF MD progression in eyes from individuals of AD.

Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.

DL models enable the estimation of VF loss from OCTA images with high accuracy.

Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma.

Optic disc microvasculature reduction was associated with VF progression even after adjusting for possible influencing factors including retinal nerve fiber layer thinning in POAG.

Reduction of Optic Disc Microvasculature and Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma.

Reduction of optic disc microvasculature was associated with rapid RNFL thinning in POAG. This suggests a role for deep optic nerve head circulation in the glaucoma pathogenesis.

Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma.

Central VF change had a greater impact on VRQOL compared to global VF change.

Association of Long-Term Intraocular Pressure Variability and Rate of Ganglion Complex Thinning in Patients With Glaucoma.

IOP variability showed an independent association with macular change in patients with glaucoma regardless of severity at baseline, even after adjustment for mean IOP, supporting its potential value as a therapeutic target for clinical decision-making.

Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma.

OCT-RNFLT has lower diagnostic accuracy in eyes of AD compared to those of ED.

Racial Differences in the Diagnostic Accuracy of OCT Angiography Macular Vessel Density for Glaucoma.

Diagnostic performance of OCTA macular VD, but not GCC thickness, for glaucoma detection varies by race.

Performance of General-Purpose Vision Language Models and Ophthalmology Foundation Models in Glaucoma Detection and Function Prediction.

Fine-tuned VLMs demonstrated high performance in glaucoma detection and VF MD prediction, matching or exceeding specialized foundation models and traditional convolutional neural network (CNN)-based methods.

Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.

MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia.

Rates of Choriocapillaris Microvascular Dropout and Macular Structural Changes in Glaucomatous Optic Neuropathy With and Without Myopia.

Rates of GCIPL thinning were associated with rates of MvD area and angular circumference change over time in myopic POAG eyes.

Glaucoma Progression Detection Time Using OCT and OCTA in African and European Descendants.

Using computer simulation, there was no racial difference in OCT and OCTA time to progression detection between AD and ED.

Predicting Perimetric Glaucoma Development in Suspects Using Widefield OCT-Based Risk Scores.

Baseline OCT-based risk scores from a single wide scan, incorporating both peripapillary RNFL and macular thickness measurements, are associated with the subsequent development of perimetric glaucoma development in glaucoma suspect eyes, offering valuable insights for…

Longitudinal Measurement of Optic Disc Vessel Density to Detect Glaucoma Progression in High Myopia.

In highly myopic glaucomatous eyes, progressive ODVD reduction was associated with VF progression, whereas RNFL thinning was not.

Comparison of Methods for Visual Field Progression in Eyes With Central Visual Field Defects.

Agreement among methods for central VF progression monitoring is low to moderate. Concordance between 24-2 and 10-2 VF methods is variable, with 10-2 detecting a higher proportion of central progression.

Deep Learning Estimation of 24-2 Visual Field Map From Optic Nerve Head Optical Coherence Tomography Angiography.

DL models from OCTA images demonstrated high accuracy in estimating 24-2 VF maps by leveraging information from ONH layers.

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Increasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year.

Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma.

Retinal oximetry enabled the continuous quantitative measurement of retinal StO 2. Increased StO 2 was significantly associated with the severity of VF damage in patients with glaucoma.

Association between metformin use with circumpapillary retinal nerve fibre layer thickness and capillary vessel density in glaucoma.

Metformin use was associated with higher wiCD and thicker cpRNFL.

Detection of glaucoma progression on longitudinal series of en-face macular optical coherence tomography angiography images with a deep learning model.

The optimised DL model detected glaucoma progression based on longitudinal macular OCTA images showed good performance. With external validation, it could enhance detection of glaucoma progression.

Association of foveal avascular zone change and glaucoma progression.

Significant FAZ increase was weakly associated with moderately faster rates of both GCC thinning and VF MD loss, but not macular vessel density change in glaucoma eyes.

Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.

Although some predictors were identified, long-term RNFLT variability appeared small for both AD and ED eyes.