Moghimi Sasan

Development and Validation of a Deep Learning System to Detect Glaucomatous Optic Neuropathy Using Fundus Photographs.

Application of GD-CNN to fundus images from different settings and varying image quality demonstrated a high sensitivity, specificity, and generalizability for detecting GON.

Measurement Floors and Dynamic Ranges of OCT and OCT Angiography in Glaucoma.

In late-stage glaucoma, particularly when VF MD is worse than -14 dB, OCTA-measured pfVD is a promising tool for monitoring progression because it does not have a detectable measurement floor.

Macular and Optic Nerve Head Vessel Density and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma.

Lower baseline macular and optic nerve head (ONH) vessel density are associated with a faster rate of RNFL progression in mild to moderate glaucoma.

Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma.

Loss of OCT-A macula vessel density is associated with central 10-2 VF defects. Macula vessel density is a clinically relevant parameter that may enhance monitoring of glaucoma suspects and patients.

Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma.

Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes.

Optical Coherence Tomography Angiography in Glaucoma.

OCTA also adds information about glaucoma patients at risk of faster progression. OCTA, therefore, complements visual field and OCT examinations to diagnose glaucoma, detect progression, and assess risk of progression.

Ganglion Cell Complex Thickness and Macular Vessel Density Loss in Primary Open-Angle Glaucoma.

Both GCC thinning and macular vessel density decrease were detectable over time in all diagnostic groups.

Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes.

Inter-eye vessel density asymmetry can be quantified by OCT-A measurement.

Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma.

ONH and macula OCTA VD and thickness are associated with the severity of visual field damage in advanced primary open angle glaucoma.

OCT Angiography Artifacts in Glaucoma.

OCTA artifacts associated with poor-quality images are frequent, and their prevalence is affected by ocular and patient characteristics.

Deep Neural Network for Scleral Spur Detection in Anterior Segment OCT Images: The Chinese American Eye Study.

A deep neural network can detect the scleral spur on AS-OCT images with performance similar to that of a human expert grader.

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients.

POAG patients with treated type 2 DM, who had no detectable diabetic retinopathy, had significantly slower rates of RNFL thinning compared to those without diagnosed DM.

Deep Learning Image Analysis of Optical Coherence Tomography Angiography Measured Vessel Density Improves Classification of Healthy and Glaucoma Eyes.

Deep learning en face image analysis improves on feature-based GBC models for classifying healthy and glaucoma eyes.

Gradient-Boosting Classifiers Combining Vessel Density and Tissue Thickness Measurements for Classifying Early to Moderate Glaucoma.

GBCs that combine OCTA and OCT macula and ONH measurements can improve diagnostic accuracy for glaucoma detection compared to most but not all instrument provided parameters.

Diagnostic Ability of Optical Coherence Tomography Angiography Macula Vessel Density for the Diagnosis of Glaucoma Using Difference Scan Sizes.

The diagnostic accuracy of VD using the 6×6 mm macula OCT-A scan was better than the 3×3 mm scan when differentiating between healthy and mild glaucoma eyes, and similar to the 3×3 mm scan when differentiating between healthy…

A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy.

Both techniques of MMC delivery (subconjunctival injection and direct scleral application) resulted in comparable surgical outcomes and bleb morphologies.

Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode.

Vessel density decreased over 6 weeks after an APAC episode compared with the contralateral unaffected eyes. In contrast, there was an initial increase in RNFL thickness that was followed by a subsequent decrease.

Ocular Biometric Determinants of Anterior Chamber Angle Width in Chinese Americans: The Chinese American Eye Study.

ACD, LV, and IC are the strongest determinants of angle width in Chinese Americans.

Impact of Smoking on Visual Field Progression in a Long-term Clinical Follow-up.

Heavy smokers are more likely to sustain VF loss in eyes with glaucoma.

Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma.

The findings of this cohort study suggest that faster vessel density loss during an initial follow-up period was associated with faster concurrent and subsequent rates of visual field loss during an extended period.

Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma.

In pseudoexfoliation, LC thinning is an early sign, and there is progressive thinning with advancing glaucoma.

Predictors of intraocular pressure change after phacoemulsification in patients with pseudoexfoliation syndrome.

Non-glaucomatous patients with PXS experience moderate IOP reduction following phacoemulsification, and this effect is correlated with preoperative IOP, aspiration time and infusion fluid used intraoperatively.

Anterior segment parameters as predictors of intraocular pressure reduction after phacoemulsification in eyes with open-angle glaucoma.

In eyes with OAG, IOP reduction after cataract surgery was greater in eyes with narrower angles. Preoperative IOP, angle-opening distance, and lens vault were predictors for IOP reduction.

Superficial and Deep Macula Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

SCP vessel densities have better diagnostic accuracy for detecting glaucoma than DCP vessel densities. Although the diagnostic accuracy of the macula SCP is relatively modest, it is more informative than the DCP.

Macular Vascularity in Ischemic Optic Neuropathy Compared to Glaucoma by Projection-Resolved Optical Coherence Tomography Angiography.

In NAION and POAG with similar RNFL and macular damage, macular OCT-A shows less involvement of superficial and deep vascular plexus in NAION in contrast to POAG, which might show a primary vascular insult in…

Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma.

Reduced PPCMv density in POAG eyes shows that deep optic nerve head ocular blood flow may contribute to axonal damage in patients with glaucoma.

Anterior Segment Dimensions Following Laser Iridotomy in Acute Primary Angle Closure and Fellow Eyes.

In APAC eyes and their fellow eyes, LPI resulted in significant anterior chamber angle widening and increased anterior chamber area.

Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in Glaucoma.

Lower corneal hysteresis was significantly associated with posterior displacement of the anterior lamina cribrosa over time. These data provide additional support for lower corneal hysteresis being a risk factor for glaucoma progression.

Association of Intraocular Pressure With Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma.

In this study, intraocular pressure variability was independently associated with structural change in patients with glaucoma, even after adjustment for mean intraocular pressure, supporting its potential value in clinical management.

Distribution of intraocular pressure, central corneal thickness and vertical cup-to-disc ratio in a healthy Iranian population: the Yazd Eye Study.

Mean IOP, CCT and VCDR were 14.2 ± 2.5 mmHg, 543 ± 35 μm and 0.32 ± 0.14, respectively, in healthy Iranians that is different from other ethnicities. It seems advisable to pay attention to ethnicity for interpretation of each person's variables.

Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements.

The proposed CNNmodel improved the estimation of 10-2 VF map based on circumpapillary SD-OCT RNFL thickness measurements.

Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.

Longitudinal OCTA measurements complement OCT-derived structural metrics for the evaluation of functional VF loss in patients with glaucoma.

A Bibliometric and Mapping Analysis of Glaucoma Research between 1900 and 2019.

A total of 33 631 original articles were collected from the timeframe 1900 through 2019.

Central-most Visual Field Defects in Early Glaucoma.

Given the significance and effect of perimetric factors at abnormal test points in the central 5 degrees of 24-2 VFs, these eyes deserve attention to determine the severity of and functional impact on the CMVFD…

Differences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study.

Differences in biometric measurements between subtypes of PACD eyes were small in a population-based cohort of Chinese Americans.

Macular Thickness and Microvasculature Loss in Glaucoma Suspect Eyes.

Whereas the rate of GCC thinning was faster on average in suspect eyes than in healthy eyes, some suspect eyes showed significant loss of vessel density and faster vessel density loss than GCC thinning.

Is Diabetes Mellitus a Blessing in Disguise for Primary Open-angle Glaucoma?

This article discusses progress in understanding the complex relationship between these 2 entities and recent shifts in perspective that challenge the traditional dogma regarding diabetes mellitus and primary open-angle glaucoma.

Visual Field Artifacts in Glaucoma With Face Mask Use During the COVID-19 Pandemic.

Fogging can result in unreliable VF testing with glaucoma-like artifacts. Secure taping of the face mask to the nose bridge may minimize this problem and reduce unnecessary additional testing and follow-up visits.

Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric Glaucoma Patients.

These findings suggest that patients with perimetric and preperimetric glaucoma have worse VRQOL than patients with healthy eyes.

Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.

Topical administration of LBN enhanced macular VD in patients with OAG or patients with OHT. In contrast, timolol administration did not have any effect on VD.

Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.

Lower macular SVD, and not DVD, was associated with a higher probability of past VF progression.

Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma.

Lower superficial vessel density measured using OCTA was significantly associated with faster VF progression in PACG. In these eyes, OCTA parameters can serve as biomarker suggestive of past VF progression.

Association Between Lamina Cribrosa Defects and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma.

These data suggest that LC defects are an independent risk factor for RNFL thinning and that glaucoma progression may correspond topographically to the LC defect location.

Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure.

Differences in ocular biometric parameters can be detected between fellow eyes of APAC and phacomorphic AC.

Association Between Rate of Ganglion Cell Complex Thinning and Rate of Central Visual Field Loss.

In this cohort study, rapid GCC thinning during an initial follow-up period was associated with faster rates of central visual field decline.

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor of Central Visual Field Progression in Glaucoma.

Lower CH was associated with a statistically significant, but relatively small, increased risk of central VF progression on the 10-2 test grid.

Estimated Utility of the Short-term Assessment of Glaucoma Progression Model in Clinical Practice.

In this cohort study, results from the STAGE model with reduction of the rate of progression as the end point, frequent testing, and a moderate effect size, suggest that clinical trials to test efficacy of…

Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.

A progressive decrease in outer PPCMv from the control group to those with PXS without glaucoma to those with PXS and glaucoma (PXG) showed deep peripapillary vasculopathy in pseudoexfoliation syndrome.

Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes.

The severity and prevalence of central VF loss varied among different glaucomatous optic disc phenotypes.

Excisional Bleb Revision for Management of Failed Ahmed Glaucoma Valve.

Excisional bleb revision could be considered as a relatively effective alternative option for management of inadequate IOP control after AGV implantation.

Association of Rates of Ganglion Cell and Inner Plexiform Thinning With Development of Glaucoma in Eyes With Suspected Glaucoma.

This study found that faster rates of GCIPL and cpRNFL thinning were associated with higher risks of developing perimetric glaucoma.

Perimetric Comparison Between the IMOvifa and Humphrey Field Analyzer.

In this cross-sectional study, 138 eyes (including 25 healthy, 48 glaucoma suspects, and 65 primary open angle glaucoma) of 69 patients were evaluated.

Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma.

Smoking intensity is associated with reduced optic nerve vessel density in glaucoma.

Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage.

Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location.

Changes in Corneal Biomechanics and Glaucomatous Visual Field Loss.

Visual field progression was associated with a lower baseline CH and a decrease in CRF over time.

Effect of Angle Narrowing on Sectoral Variation of Anterior Chamber Angle Width: The Chinese American Eye Study.

Correlations between mean and sectoral variation of ACA width strengthen as the severity of angle narrowing worsens.

Macular Vessel Density in Glaucomatous Eyes With Focal Lamina Cribrosa Defects.

Although OCTA macular vessel density was not significantly different between eyes with and without LC defects, focal GCC loss in eyes with LC defects was different.

Rate of Initial Optic Nerve Head Capillary Density Loss and Risk of Visual Field Progression.

Rapid initial optic nerve head capillary density loss from OCTA was associated with a faster rate of visual field progression and a doubling of the risk of developing event progression in this study.

Prevalence and Risk Factors of Blindness Among Primary Angle Closure Glaucoma Patients in the United States: An IRIS Registry Analysis.

Blindness affects 1 of 9 patients with newly diagnosed PACG in the IRIS Registry.

Usability and Clinician Acceptance of a Deep Learning-Based Clinical Decision Support Tool for Predicting Glaucomatous Visual Field Progression.

A CDS tool can be designed to present AI model outputs in a useful, trustworthy manner that clinicians are generally willing to integrate into their clinical decision-making.

Impact of Pupil Dilation on Optical Coherence Tomography Angiography Retinal Microvasculature in Healthy Eyes.

Pupil dilation using topical 2.5% phenylephrine and 0.5% tropicamide results in a small but statistically significant reduction in non-HD ONH whole image and cpCD in healthy eyes.

Combined glaucoma and cataract surgery: Comparison of viscocanalostomy, endocyclophotocoagulation, and ab interno trabeculectomy.

All procedures significantly lowered IOP. Phacoemulsification-ab interno trabulectomy resulted in fewest complications and phacoviscocanalostomy led to the largest IOP drop and largest reduction of medications.

Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma.

Rates of MvD area and angular circumference change over time were associated with concurrent rates of cpRNFL loss in POAG eyes.

Measurements of OCT Angiography Complement OCT for Diagnosing Early Primary Open-Angle Glaucoma.

Associations between capillary density and visual function were found in the regions known to be at highest risk for damage in preperimetric glaucoma eyes and all regions of mild glaucoma eyes.

Longitudinal Structure-Function Relationship between Macular Vessel Density and Thickness and Central Visual Field in Early Glaucoma.

Rates of VD loss and GCC thinning are associated with central VF loss over time. Assessment of both macular VD and GCC thickness should be considered for evaluation of glaucoma progression.

Diurnal Variation of Retinal Vessel Density in Healthy Human Eyes.

There was a small increase in ONH VD, but not macular VD, in the evening compared with the morning in healthy human eyes.

Comparison of Anterior Chamber Parameters in Patients With Plateau Iris Configuration and Pupillary Block Using ASOCT.

ASOCT parameters are not significantly different between PB and PIC eyes. PIC eyes may have greater IT at its base.

Nocturnal Variability of Intraocular Pressure Monitored With Contact Lens Sensor Is Associated With Visual Field Loss in Glaucoma.

Twenty-four-hour CLS recording of IOP-related ocular dimensional change was associated with faster VF progression. Such CLS recordings are useful to assess the risk of in progression in POAG patients.

Comparison of Peripapillary Capillary Density in Glaucoma Patients of African and European Descent.

Although peripapillary capillary density parameters showed good diagnostic accuracy for detecting glaucoma in ED patients, their diagnostic accuracy was only modest in AD patients.

Relationship of the Macular Ganglion Cell and Inner Plexiform Layers in Healthy and Glaucoma Eyes.

Ethnicity and distance from the fovea are the main determinants of IPL thickness in the central macula.

Retinal Nerve Fiber Layer Optical Texture Analysis and 10-2 Visual Field Assessment in Glaucoma.

Papillomacular and papillofoveal RNFL bundle defects are present in a considerable proportion of eyes with glaucoma.

Performance of ChatGPT on Responding to Common Online Questions Regarding Key Information Gaps in Glaucoma.

Progressive Visual Field Loss and Subsequent Quality of Life Outcomes in Glaucoma.

Baseline severity and initial rates of change of VF damage are associated with QOL outcomes over an extended follow-up.

Racial Differences in Detection of Glaucoma Using Retinal Nerve Fiber Layer Thickness and Bruch Membrane Opening Minimum Rim Width.

RNFLT and BMO-MRW had consistently lower diagnostic performance in AD individuals compared with ED individuals.

Effect of Testing Frequency on the Time to Detect Glaucoma Progression With Optical Coherence Tomography (OCT) and OCT Angiography.

The time required to detect a statistically significant negative cpRNFL and cpCD slope decreased as the testing frequency increased, albeit not proportionally.

Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers.

After ≥25 years of smoking cessation, the risk of VF progression in former heavy smokers becomes similar to never smokers. Long-term smoking cessation may be associated with lower VF progression in glaucoma patients.

Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography.

After excluding 4 eyes because of poor imaging of the scleral spur, data from 34 eyes with PEXG, 33 eyes with PEX, and 31 eyes of normal control subjects were analyzed.

Long-Term Blood Pressure Variability and Visual Field Progression in Glaucoma.

In this cohort study, higher mean blood pressure and higher SD of blood pressure were associated with faster VF progression.

Time to Glaucoma Progression Detection by Optical Coherence Tomography in Individuals of African and European Descents.

Time to progression detection was similar for both races when assuming identical RNFLT baseline/thinning rates, and shorter in AD eyes under real-world simulation when AD had faster RNFLT thinning.

Clinical Factors Associated With Long-Term OCT Variability in Glaucoma.

Relevant clinical factors affecting long-term RNFLT variability in glaucoma were identified.

Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma.

These findings suggest that faster and sectoral central location of ganglion cell complex thinning provides useful information in determining the risk of vision-related quality of life in glaucoma.

Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.

Circumpapillary CD measurements showed a dose-dependent increase with the induction of negative pressure, while RNFL thickness measurements remained unchanged.

Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage.

The rate of mGCIPL and cpRNFL thinning was faster in DH eyes than non-DH eyes.

Capillary Density Measured by Optical Coherence Tomography Angiography in Glaucomatous Optic Disc Phenotypes.

OCTA-measured vessel density differs among optic disc phenotypes. Clinicians should be aware that the performance of OCTA for glaucoma diagnosis may be influenced by the optic disc phenotype.

Screening of Glaucoma: Consensus and Directions.

We discuss barriers to glaucoma screening and recent advancements in glaucoma detection and care, including targeted screening approach as well as telemedicine, genetic testing, and artificial intelligence (AI).

Relationship of Choroidal Microvasculature Dropout and Beta Zone Parapapillary Area With Visual Field Changes in Glaucoma.

MvD area rates, but not β-PPA area rates, were associated with VF MD loss changes in eyes with POAG.

The Association Between Regional Macula Vessel Density and Central Visual Field Damage in Advanced Glaucoma Eyes.

Given a stronger MVD-central 10-degree VF association compared with GCC, as well as stronger GCC-central 5-degree VF association compared with MVD, MVD and GCC are complementary measurements in eyes with advanced glaucoma.

Rates of Circumpapillary Retinal Nerve Fiber Layer Thinning and Capillary Density Loss in Glaucomatous Eyes with Disc Hemorrhage.

Mean rates of vessel density loss between DH and non-DH eyes were different not only in the affected area but also in the other regions.

Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Open Angle Glaucoma.

Lower baseline peripapillary PD and VD measured using OMAG were significantly associated with a faster rate of RNFL loss in POAG.

Time to Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field in Glaucoma Individuals of African Descent.

Computer simulation showed a potentially shorter time to detect RNFLT progression than VF MD progression in eyes from individuals of AD.

Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.

DL models enable the estimation of VF loss from OCTA images with high accuracy.

Longitudinal OCTA vessel density loss in macula and optic nerve head in healthy, glaucoma suspect and established glaucoma eyes.

In glaucoma, there is earlier microvasculature loss in the ONH than in the macula.

Association Between Longitudinal 10-2 Central Visual Field Change and the Risk of Visual Acuity Loss in Mild-to-Moderate Glaucoma.

Faster 10-2 VF MD and hemifield MS worsening are associated with the development of VA loss. Monitoring the longitudinal central 10-degree VF change may suggest that there is impending VA impairment in glaucoma.

Association between Rates of Retinal Nerve Fiber Layer Thinning after Intraocular Pressure-Lowering Procedures and Disc Hemorrhage.

POAG or glaucoma suspect eyes with a history of DH should be carefully followed after IOP-lowering procedures.

Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma.

Central VF change had a greater impact on VRQOL compared to global VF change.

Intraocular Pressure Matters.

Additionally, maintaining stable IOP by minimizing both diurnal and long-term fluctuations may further enhance disease control and reduce the risk of worsening.

Optic Disc Size and Circumpapillary Retinal Nerve Fiber Layer Thinning in Glaucoma.

Larger optic disc size is associated with faster cpRNFL thinning in glaucoma, independent of race.

Association of Long-Term Intraocular Pressure Variability and Rate of Ganglion Complex Thinning in Patients With Glaucoma.

IOP variability showed an independent association with macular change in patients with glaucoma regardless of severity at baseline, even after adjustment for mean IOP, supporting its potential value as a therapeutic target for clinical decision-making.

Smoking Intensity is Associated With Progressive Optic Nerve Head Vessel Density Loss in Glaucoma.

A history of greater smoking consumption was associated with faster vessel density loss, suggesting smoking intensity as a potential risk factor for glaucoma.

Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma.

OCT-RNFLT has lower diagnostic accuracy in eyes of AD compared to those of ED.

Racial Differences in the Diagnostic Accuracy of OCT Angiography Macular Vessel Density for Glaucoma.

Diagnostic performance of OCTA macular VD, but not GCC thickness, for glaucoma detection varies by race.

Effect of Corneal Hysteresis on the Rates of Microvasculature Loss in Glaucoma.

Lower CH values were significantly associated with faster rates of wiCD loss over time.

Comparison of Vascular Density and Structural Patterns Between Primary Open Angle Glaucoma and Primary Angle Closure Glaucoma.

PACG and POAG eyes with similar visual field damages have comparable structural damage patterns in the peripapillary and inner macular thickness and vessel density measurements.

Prediction of Central Visual Field Severity in Glaucoma.

Clinicians may predict the severity of CVFDs on 24-2 VF and parafoveal scotomas on 10-2 VF by measuring threshold sensitivities and defect values at abnormal central 12 points (<1%) on 24-2 VF in early glaucoma.

OCT-Angiography Face Mask-Associated Artifacts During the COVID-19 Pandemic.

Face mask wearing had no significant effect on area of artifacts or vessel density measurements. OCT-A vessel density measurements can be acquired reliably with face mask wear during the pandemic.

Optical Microangiography and Progressive Ganglion Cell-Inner Plexiform Layer Loss in Primary Open-Angle Glaucoma.

Lower baseline peripapillary OMAG measurements were significantly associated with a faster rate of GCIPL loss in patients with mild to moderate POAG.

Agreement between Compass Fundus Perimeter New Grid and 10-2 Testing Protocols for Detecting Central Visual Field Defects.

Although the Compass NG detected fewer CVFDs than the 10-2 test protocol, it did detect CVFDs that were not observed in the Compass 24-2 test in patients with early glaucoma.

Rates of Retinal Nerve Fiber Layer Thinning in Distinct Glaucomatous Optic Disc Phenotypes in Early Glaucoma.

Rates of cpRNFL thinning were different among the 4 glaucomatous optic disc phenotypes.

Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma.

ROTA uncovers a wide spectrum of RNFL bundle defects spanning the entire glaucoma continuum.

Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.

MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia.

Publication Rates and Patterns of Registered Glaucoma Trials.

Only about half of all registered glaucoma trials from ClinicalTrials.gov were published, with less than 25% complying with the mandated FDA report period of 1 to 2 years and overall, a significant delay of nearly…

Impact of Physical Activity Levels on Visual Field Progression in Individuals With Glaucoma.

Higher PA amounts are an independent predictor of a slower rate of VF MD loss. Further research is needed to explore whether increased PA protects against glaucoma progression.

Association Between Alcohol Use and Primary Open Angle Glaucoma.

In the diverse All of Us database, there was a dose-response relationship between alcohol consumption and POAG risk, which was more pronounced in female participants.

Short-Term Rates of Visual Field Change Predict Glaucoma Progression.

The initial 2-year rate of VF MD change predicts subsequent progression events based on FDA-consistent criteria in both early and moderate-to-advanced glaucoma eyes.

Rates of Choriocapillaris Microvascular Dropout and Macular Structural Changes in Glaucomatous Optic Neuropathy With and Without Myopia.

Rates of GCIPL thinning were associated with rates of MvD area and angular circumference change over time in myopic POAG eyes.

Response to Letter to the Editor: Superficial and Deep Macula Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

Glaucoma Progression Detection Time Using OCT and OCTA in African and European Descendants.

Using computer simulation, there was no racial difference in OCT and OCTA time to progression detection between AD and ED.

Proportion of Fast Progressors in the Central versus Global Visual Field Across Varying Glaucoma Severity Groups.

Selective analysis of the MTDdetected a greater proportion of eyes that exhibited fast progression across all disease severity groups compared to measurements from the entire VF, underscoring the importance of close monitoring for progressive central…

Predicting Perimetric Glaucoma Development in Suspects Using Widefield OCT-Based Risk Scores.

Baseline OCT-based risk scores from a single wide scan, incorporating both peripapillary RNFL and macular thickness measurements, are associated with the subsequent development of perimetric glaucoma development in glaucoma suspect eyes, offering valuable insights for…

Comparison of Methods for Visual Field Progression in Eyes With Central Visual Field Defects.

Agreement among methods for central VF progression monitoring is low to moderate. Concordance between 24-2 and 10-2 VF methods is variable, with 10-2 detecting a higher proportion of central progression.

Deep Learning Estimation of 24-2 Visual Field Map From Optic Nerve Head Optical Coherence Tomography Angiography.

DL models from OCTA images demonstrated high accuracy in estimating 24-2 VF maps by leveraging information from ONH layers.

Initial circumpapillary retinal nerve fibre layer rates of change predict glaucomatous progression.

The rate of initial cpRNFL change observed within half the monitoring period may effectively predict the subsequent structural progression and can be used by clinicians to predict the course of glaucoma when monitoring patients.

Association Between Optic Nerve Head Prelaminar Schisis and Visual Field Progression in Glaucoma.

The presence and severity of severe prelaminar schisis were associated with faster VF progression, suggesting its potential as a biomarker to identify patients at higher risk of progression and to guide clinical management in glaucoma.

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Increasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year.

Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Angle Closure Glaucoma.

Younger patient age and greater peak IOP during follow-up were significantly associated with a faster rate of RNFL loss in PACG patients with mild to moderate severity of functional damage.

Rates of Visual Field Progression Before and After the Onset of Atrial Fibrillation.

The presence of atrial fibrillation and related microvascular damage might accelerate visual field loss.

Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma.

Retinal oximetry enabled the continuous quantitative measurement of retinal StO 2. Increased StO 2 was significantly associated with the severity of VF damage in patients with glaucoma.

Reply to Letter to the Editor: The Association Between Regional Macula Vessel Density and Central Visual Field Damage in Advanced Glaucoma Eyes.

Response to Letter to the Editor: Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma.

Response to: Comparison of Fellow Eye of Acute Primary Angle Closure and Phacomorphic Angle Closure.

Optic Disc Structural Progression in Glaucoma Suspect Eyes with Microvascular Dropout.

In glaucoma suspect eyes, the presence of both MvD and β-zone PPA progression were independently associated with structural optic disc progression.

Association between metformin use with circumpapillary retinal nerve fibre layer thickness and capillary vessel density in glaucoma.

Metformin use was associated with higher wiCD and thicker cpRNFL.

Detection of glaucoma progression on longitudinal series of en-face macular optical coherence tomography angiography images with a deep learning model.

The optimised DL model detected glaucoma progression based on longitudinal macular OCTA images showed good performance. With external validation, it could enhance detection of glaucoma progression.

Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.

Although some predictors were identified, long-term RNFLT variability appeared small for both AD and ED eyes.

Association of foveal avascular zone change and glaucoma progression.

Significant FAZ increase was weakly associated with moderately faster rates of both GCC thinning and VF MD loss, but not macular vessel density change in glaucoma eyes.

Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression.

OCT and OCTA showed limited agreement on event-based progression detection, with OCT showing better agreement with VF.

Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma.

Despite profound thinning and posterior displacement of LC in POAG, the thickness and position of LC in NAION eyes are similar to those seen in healthy control and their fellow eyes.

Anterior-Chamber Depth in Plateau Iris Syndrome.

Changes in Anterior Segment Morphology After Laser Peripheral Iridotomy in Acute Primary Angle Closure.

This study confirms that LPI results in a significant increase in the angle width, ACD, and ACA as well as flattening of the iris in APAC eyes.

Lens Position Parameters as Predictors of Intraocular Pressure Reduction After Cataract Surgery in Glaucomatous Versus Nonglaucomatous Eyes.

Intraocular pressure reduction after phacoemulsification cataract surgery in nonglaucomatous eyes is significantly greater in more anteriorly positioned lenses.

Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open-Angle Glaucoma.

Patients with NAION show differences in the tissue damage with greater loss of parafoveal GCIPL tissue thickness compared to patients with POAG.

Short-term Results of Trabeculectomy Using Adjunctive Intracameral Bevacizumab: A Randomized Controlled Trial.

A single 1.25 mg dose of intracameral bevacizumab significantly improves the success of trabeculectomy; however, it increases the risk of early filtering bleb leakage.

Evaluation of the "IS" Rule to Differentiate Glaucomatous Eyes From Normal.

The ISNT rule alone has a high sensitivity but relatively low specificity.

Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes.

Ocular biometric parameters can differentiate phacomorphic angle closure from APAC eyes. Shallower ACD and greater LV, axial length, and ACA are the main parameters that distinguish phacomorphic angle closure from APAC.

Phacoemulsification Versus Combined Phacoemulsification and Viscogonioplasty in Primary Angle-Closure Glaucoma: A Randomized Clinical Trial.

Phaco alone and Phaco-VGP resulted in widening of the drainage angle, reduction of IOP, and PAS extent in PACG eyes.