Monisha E. Nongpiur

Efficacy of Phacoemulsification Alone vs Phacoemulsification With Goniosynechialysis in Patients With Primary Angle-Closure Disease: A Randomized Clinical Trial.

This randomized clinical trial was unable to show that PEI-GSL added additional IOP lowering compared with PEI alone in patients with PACD.

Mendelian Randomization Implicates Bidirectional Association between Myopia and Primary Open-Angle Glaucoma or Intraocular Pressure.

A strong bidirectional genetic causal link exists between myopia and POAG that is mediated mainly by IOP.

Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes.

In a South Indian population with PACS or PAC/PACG, LPI results in significant anterior chamber angle widening seen on both ASOCT and gonioscopy, although some degree of persistent iridotrabecular contact was present in approximately half…

Association of Baseline Anterior Segment Parameters With the Development of Incident Gonioscopic Angle Closure.

These findings suggest that smaller AOD750 and larger LV measurements are associated with the development of incident gonioscopic angle closure after 4 years among participants with gonioscopically open angles at baseline.

Diagnostic Ability of Individual Macular Layers by Spectral-Domain OCT in Different Stages of Glaucoma.

Single-layer mGCL thickness is comparable to the traditional cpRNFL thickness for the diagnosis of early/moderate glaucoma, whereas cpRNFL thickness remains the most efficient for advanced glaucoma.

Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis.

In patients with PACG being managed in a hospital setting, VF progression was noted in 15.8%, and the overall rate of VF loss was -0.12±0.51 dB/year.

Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma.

Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements.

Six-Year Incidence and Risk Factors for Primary Angle-Closure Disease: The Singapore Epidemiology of Eye Diseases Study.

Our study showed that the 6-year incidence of PACD was 3.50%.

Distinct iris gene expression profiles of primary angle closure glaucoma and primary open angle glaucoma and their interaction with ocular biometric parameters.

Distinct iris gene expression supports the pathophysiological differences that exist between PACG and POAG. Biometric parameters can combine with iris gene expression to more accurately define PACG from POAG.

Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease.

In this study, 2 of 8 PACG-associated loci were associated significantly with PACS status, the earliest stage in the angle-closure glaucoma disease course.

Young's Modulus Determination of Normal and Glaucomatous Human Iris.

Variations in biomechanical properties of iris tissue may have a significant role in the pathogenesis of angle closure glaucoma.

Association of Functional Loss With the Biomechanical Response of the Optic Nerve Head to Acute Transient Intraocular Pressure Elevations.

The biomechanical response of the ONH to acute IOP elevations was associated with established visual field loss in POAG eyes, but not in primary angle-closure glaucoma eyes.

Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci for Estimating Angle Closure Disease Severity.

Our results show that EPDR1 is associated significantly with severe PACG, suggesting that it may predispose patients to more aggressive disease development.

The Effect of Medical Lowering of Intraocular Pressure on Peripapillary and Macular Blood Flow as Measured by Optical Coherence Tomography Angiography in Treatment-naive Eyes.

The reduction of IOP by a PGA in treatment-naive eyes was significantly correlated to the increase in ONH VD and RPC VD.

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects.

In this sample, subjects with glaucoma exhibited tauter optic nerves and more protruding eye globes compared with normal eyes. This may impact optic nerve head deformations in anatomically predisposed patients.

Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma.

The proportion of plateau iris was similar across the three ASOCT-based PACG subgroups and more than one-third of subjects with PACG were diagnosed with plateau iris based on standardized UBM criteria.

Characteristics of the Corneal Endothelium Across the Primary Angle Closure Disease Spectrum.

The corneal ECD and morphological characteristics such as CV and hexagonality are not significantly different across the PAC disease spectrum.

Plateau Iris and Severity of Primary Angle Closure Glaucoma.

The higher proportion of plateau iris configuration in eyes with severe PACG compared with early-to-moderate PACG suggest that this may be a contributory factor for disease severity.

Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma.

Although significant on their own, the incorporation of genetic data in the context of anterior segment imaging parameters like ACD provided only a marginal improvement of PACG detection.

Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults.

Chinese have lower CH than Indian persons, and this disparity may reflect biomechanical differences of the cornea.

Multivariate Normative Comparison, a Novel Method for Improved Use of Retinal Nerve Fiber Layer Thickness to Detect Early Glaucoma.

The multivariate normative database of RNFL showed better glaucoma discrimination capability than conventional age-matched comparisons, suggesting that accounting for demographic and anatomic variance in RNFL thickness may have usefulness in improving glaucoma detection.

Retinal Oximetry in Subjects With Glaucomatous Hemifield Asymmetry.

In our study, localized visual field losses were not associated with changes in retinal oximetry but were associated with narrower retinal arteriolar diameters in PACG and NTG.

Six-Year Incidence and Risk Factors for Primary Open-Angle Glaucoma and Ocular Hypertension: The Singapore Epidemiology of Eye Diseases Study.

Six-year incidence of POAG was 1.31% in a multiethnic Asian population.

Development and Validation of a Preference-Based Glaucoma Utility Instrument Using Discrete Choice Experiment.

Use of Glau-U revealed large decrements in utility that were associated with late-stage glaucoma, suggesting that this new instrument may be useful for cost-effectiveness analyses of interventions and informing resource allocation policies for glaucoma and…

Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease?

Advances in anterior segment optical coherence tomography technology have further enhanced our understanding of the risk factors and mechanisms involved in the disease process.

Intraocular pressure change after phacoemulsification in angle-closure eyes without medical therapy.

The mean IOP reduction 6 months after phacoemulsification was 20%. Less IOP reduction was observed in the presence of lower preoperative IOP and more extensive PAS.

Deep Learning Classification of Angle Closure based on Anterior Segment OCT.

Convolutional neural network classifiers can effectively distinguish PACD from controls on AS-OCT with good generalizability across different patient cohorts. However, their performance is moderate when trying to distinguish PACS versus PAC + PACG.

Association of iris crypts with acute primary angle closure.

Our study comprising Asian eyes with angle closure suggests that the presence of a higher crypt grading may be protective for APAC.

Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains.

Our study has shown that the integration of biomechanical data can significantly improve the accuracy of visual field loss predictions and highlights the importance of the biomechanics-function relationship in glaucoma.

Iris Morphological and Biomechanical Factors Influencing Angle Closure During Pupil Dilation.

The morphology of the iris (IT and IC) and its innate biomechanical behavior (E and v) were crucial in influencing the way the iris deformed during dilation, and angle closure was further exacerbated by decreased…

Comparison of intraocular pressure and anterior segment parameters in subjects with asymmetrical primary angle closure disease.

PACG eyes have higher presenting IOP, smaller anterior segment parameters, greater extent of PAS, and larger LV compared to their fellow eyes with angle closure.

Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial.

After APAC, there was no difference in VF progression (or RNFL thickness change) between Cop-1 and placebo groups. However, there was improvement of MD in Cop-1 treated patients.

Mechanisms underlying acute angle closure.

Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography.

Anterior chamber scan had low inter-observer and intra-observer variability in quantitative evaluation that was not affected by the angle status or the experience of an operator.

Characteristics of Eyes With Asymptomatic Primary Angle Closure Glaucoma With Varying Severity of Visual Field Loss at Presentation.

Similar age at presentation of severe PACG and those with less severe disease suggests that the severe group either developed PACG at an earlier age or underwent rapid disease progression.

The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties.

We have established a new protocol to evaluate the biomechanical properties of the structural layers of the iris.

AI to Identify Strain-Sensitive Regions of the Optic Nerve Head Linked to Functional Loss in Glaucoma.

ONH strain enhances classification of glaucomatous VF loss patterns. The neuroretinal rim, rather than the LC, was most critical, suggesting rim strain may play a dominant role in axonal injury and functional loss.

Relationship Between Central Corneal Thickness and Inter-Eye Disease Severity in Primary Angle Closure Glaucoma.

In asymmetrical PACG, worse eyes have thinner CCT and higher presenting IOP. Difference in CCT could either be inherent or acquired, and more tests would be needed to tease that out.

Subtypes of primary angle closure disease based on age-independent anterior segment optical coherence tomography parameters.

We identified 3 subgroups of angle closure eyes, each characterised by distinct structural components based on ASOCT.

Long-term Persistent Angle Closure and Anatomic Changes after Laser Iridotomy in Suspected Primary Angle-Closure.

Laser iridotomy sustained angle widening in two-thirds of patients. However, a thicker iris at baseline in narrower angles predicted persistent closure, highlighting the need for tailored management in these cases.

Optical Coherence Tomography Angiography Assessment of Optic Nerve Head and Macula Across the Primary Angle Closure Disease Spectrum.

Significant reduction in the microvasculature of the optic disc and macula in PACG suggests that glaucoma development may contribute to lower VD in these regions.

Biometric Factors Associated With Acute Primary Angle Closure: Comparison of the Affected and Fellow Eye.

Eyes with previous APAC had smaller anterior segment dimensions when compared with their fellow eyes. Iris thickness was the strongest predictor of angle width in both affected and fellow eyes.

Shape Changes of the Anterior Lamina Cribrosa in Normal, Ocular Hypertensive, and Glaucomatous Eyes Following Acute Intraocular Pressure Elevation.

Acute IOP elevations altered anterior LC shape in a complex nonlinear fashion. The LC of POAG eyes was more cupped following acute IOP elevations compared to that of normal subjects.

Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels.

In this group of clinic-based PACG patients, the superior hemifield was found to be affected more severely than the inferior hemifield, and the differences between them increased with worsening disease severity.

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.

Our models predicted high ONH strains during eye movements, which were aggravated with stiffer optic nerve sheaths.

Changes in Japanese eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study.

An increase in anterior chamber dimensions, angle widening and iris flattening; with a constant LV, iris thickness and iris area after LPI was demonstrated in Japanese eyes with angle closure.

Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial.

After 1 year, ALPI was associated with higher failure rates and lower IOP reduction compared with PGA therapy in eyes with persistent appositional angle closure and raised IOP after LI.

The Impact of Lens Vault on Visual Acuity and Refractive Error: Implications for Management of Primary Angle-closure Glaucoma.

The magnitude of LV was not associated with VA or spherical equivalent. Lens extraction may be a consideration in eyes with angle closure with large LV in the absence of visually significant cataract.

Anterior Chamber Angle and Intraocular Pressure Changes After Phacoemulsification: A Comparison Between Eyes With Closed-angle and Open-angle Glaucoma.

Angle opening postphacoemulsification was considerable in all eyes. A similar IOP reduction after phacoemulsification was observed in all eyes regardless of angle status.

Erratum. Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma.

Anterior Segment Imaging Predicts Incident Gonioscopic Angle Closure.

Anterior segment OCT imaging at baseline predicts incident gonioscopic angle closure after 4 years among subjects who have gonioscopically open angles and iridotrabecular contact on AS OCT at baseline.

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma.

Corneal biomechanical parameters measured by the ORA are not associated with severity of glaucoma in PACG.

Analysis of Association Between the Insertion Location of Iris Root and Narrow Angle.

A smaller distance from iris root to scleral spur was associated with the presence of narrow angle.

Evaluation of Choroidal Thickness, Intraocular Pressure, and Serum Osmolality After the Water Drinking Test in Eyes With Primary Angle Closure.

The increase in IOP after WDT was higher in PACG eyes compared to FE-APAC; however, the latter had lower serum osmolality at baseline.

Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects.

Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses.

Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial.

Eyes with PAC or PACG respond to SLT in the short term, but the overall long-term therapeutic effectiveness needs further evaluation.