Varma Rohit

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.

President Obama in his 2015 State of the Union address, is beginning to touch the practice of ophthalmology.

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field.

OCT is more sensitive than VF for the detection of progression in early glaucoma. While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive progression detector from early to advanced stages.

Deep Learning Classifiers for Automated Detection of Gonioscopic Angle Closure Based on Anterior Segment OCT Images.

Deep learning classifiers effectively detect gonioscopic angle closure and PACD based on automated analysis of AS-OCT images.

Baseline Fourier-Domain Optical Coherence Tomography Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Focal GCC and NFL loss as measured by FDOCT are the strongest predictors for VF progression among the measurements considered.

Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-Inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography.

Glaucomatous eyes had reduced GCIPL microcirculation. OCTA parameters had stronger associations with functional rather than structural measures of glaucoma. This observation deserves further study.

Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.

Diagnostic Performance of Macular Versus Peripapillary Vessel Parameters by Optical Coherence Tomography Angiography for Glaucoma.

Peripapillary perfusion parameters performed better than macular perfusion parameters for glaucoma diagnosis, supporting the idea that glaucomatous superficial retinal vascular changes are more pronounced in the peripapillary region.

Deep Neural Network for Scleral Spur Detection in Anterior Segment OCT Images: The Chinese American Eye Study.

A deep neural network can detect the scleral spur on AS-OCT images with performance similar to that of a human expert grader.

Correlation between Intraocular Pressure and Angle Configuration Measured by OCT: The Chinese American Eye Study.

There is an anatomic threshold for angle configuration below which IOP is strongly related to the degree of angle closure.

Variation in Intraocular Pressure and the Risk of Developing Open-Angle Glaucoma: The Los Angeles Latino Eye Study.

Maximum, SD, and range of IOP were all associated with risk of developing OAG, and SD and range of IOP remained significantly associated even after adjustment for mean IOP.

Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.

Age, sex, and systemic influences, such as diabetes duration, need to be considered when assessing changes in RPC VD in glaucoma and other ocular diseases.

Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study.

A multi-image approach should be the standard in OCT-based studies of AOD, ARA, TISA, TIA, SSAngle, IA, and LV.

Ocular Biometric Determinants of Anterior Chamber Angle Width in Chinese Americans: The Chinese American Eye Study.

ACD, LV, and IC are the strongest determinants of angle width in Chinese Americans.

Machine Learning Models for Diagnosing Glaucoma from Retinal Nerve Fiber Layer Thickness Maps.

Superior diagnostic performance was achieved with both conventional machine learning and convolutional neural net models compared with circumpapillary RNFL thickness.

Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography.

Angle assessments by gonioscopy and EyeCam are weakly related to angle dimensions in eyes with angle closure.

Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries.

Parameters from 4.5 scans generally outperformed those from 6.0 scans in the global and quadrant regions, suggesting greater digital resolution in 4.5 scans of the immediate peripapillary RPC is important in detecting glaucomatous changes.

Glaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study.

A CNN classifier can effectively detect angle closure in goniophotographs with performance comparable to that of an experienced glaucoma specialist.

Ocular Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.

Thinner RNFL and longer AL were the most influential ocular determinants of lower peripapillary perfusion in healthy AA eyes.

A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population.

Our results discovered a novel SNP that is significantly associated with VCDR in Latino individuals and confirmed previously reported loci, providing further insight into the genetic architecture of VCDR.

Differences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study.

Differences in biometric measurements between subtypes of PACD eyes were small in a population-based cohort of Chinese Americans.

Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

hdVAD is higher in early glaucoma and may help with early detection when damage is focal, but its diagnostic ability appears less robust in advanced glaucoma when damage is diffuse.

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism.

Combined measurements of retinal blood flow and oxygen saturation in glaucomatous individuals suggest VF loss is associated with impaired oxygen delivery and augmented OEF.

Ocular Biometric Determinants of Dark-to-Light Change in Angle Width: The Chinese American Eye Study.

Beneficial angle widening effects of transitioning from dark to light are attenuated in eyes with PACD, which appears related to aberrant dark-to-light change in ACW.

Effect of Angle Narrowing on Sectoral Variation of Anterior Chamber Angle Width: The Chinese American Eye Study.

Correlations between mean and sectoral variation of ACA width strengthen as the severity of angle narrowing worsens.

Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary Vessel Density in Glaucoma Patients.

Among subjects with glaucoma with longer AL, IOP was significantly associated with pVD.

Refractive Error and Anterior Chamber Depth as Risk Factors in Primary Angle Closure Disease: The Chinese American Eye Study.

The risk of PACD rises rapidly with greater hyperopia while remaining relatively low for all degrees of myopia.

Racial and Ethnic Differences in the Roles of Myopia and Ocular Biometrics as Risk Factors for Primary Open-Angle Glaucoma.

Although the POAG risk conferred by myopic RE and longer AL is similar between Latino and Chinese Americans, the difference in POAG prevalence between the two groups is narrowed by higher myopia prevalence among Chinese Americans.

Prevalence and Risk Factors of Primary Angle Closure Disease in an Adult Chinese American Population: The Chinese American Eye Study.

PACG prevalence was not substantially lower among Chinese Americans compared to mainland Chinese.

Burden and Predictors of Undetected Eye Disease in Adult African Americans: African American Eye Disease Study (AFEDS).

Our data provides evidence of the significant burden of UED among African American individuals.

Classification of Angle Closure Severity by Hierarchical Cluster Analysis of Ocular Biometrics in the Dark and Light.

Unsupervised cluster analysis of ocular biometrics can classify angle closure eyes by severity. Static biometrics measured in the light and dark are both predictive of PAC/G.

Prevalence and Risk Factors of Open-Angle Glaucoma in an Adult Chinese American Population: The Chinese American Eye Study.

The prevalence of OAG among Chinese Americans may be higher than that reported in US populations of European descent and in Asia-based Chinese populations, but lower than that observed in Latinos in Los Angeles and individuals of African Caribbean descent.

Glaucoma in the US-Gaps in Data on Racial and Ethnic Minority and Aging Populations.

The "Curse" of the Fellow Eye in Glaucoma.

Use of Structural End Points in Glaucoma: Beyond Visual Field Loss.

A Population-Based Assessment of the Agreement Between Grading of Goniophotographic Images and Gonioscopy in the Chinese-American Eye Study (CHES).

Detection of iridocorneal angle closure based on goniophotographic imaging shows moderate to very good agreement with angle closure assessment using gonioscopy.

Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis.

Our various regression approaches were not able to significantly improve disc-based OCT glaucoma diagnosis.

Longitudinal and Cross-Sectional Analyses of Age Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness by Fourier-Domain OCT.

Longitudinal and cross-sectional analyses provided consistent rates of approximately 0.2% per year of age-related thinning in NFL and GCC thicknesses.

Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography.

Reductions in NFL and GCC thickness can predict the development of glaucomatous VF loss in glaucoma suspects and preperimetric glaucoma patients.

African Ancestry Is Associated with Higher Intraocular Pressure in Latinos.

To our knowledge, we demonstrate for the first time that African ancestry and its interaction with hypertension are associated with higher IOP in Latinos.

Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography.

Combining structural measurements of GCC, NFL and disc variables from FD-OCT created a GSDI that improved the accuracy for glaucoma diagnosis.

The primary open-angle african american glaucoma genetics study: baseline demographics.

The POAAGG study has currently recruited more than 2000 African Americans eligible for a POAG genetics study.

Advanced imaging for glaucoma study: design, baseline characteristics, and inter-site comparison.

Site-to-site variation was smaller than both the variation within groups and the changes attributable to glaucoma. Therefore pooling of participants between sites is appropriate.