Macular Ganglion Cell-Inner Plexiform Layer, Ganglion Cell Complex, and Outer Retinal Layer Thicknesses in a Large Cohort of Chinese Children.
Cheng Lu, Wang Mingjin, Deng Junjie, Lv Minzhi, Jiang Wenhan, Xiong Shuyu, Sun Sifei, Zhu Jianfeng, Zou Haidong, He Xiangui
AI Summary
This study established normal macular retinal layer thicknesses in Chinese children, finding they vary significantly with age, sex, axial length, and refractive error, improving pediatric glaucoma and retinal disease diagnosis.
Abstract
Purpose
The purpose of this study was to describe the normative values, distribution patterns, and correlated factors of macular ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and outer retinal layer (ORL) thicknesses in Chinese children.
Methods
A sample of 3000 healthy children with different refractive status aged 6 to 19 years was consecutively examined. Demographics were recorded, and a comprehensive ophthalmic examination including refractive error and axial length (AL) was taken from all participants. The GCIPL, GCC, and ORL thicknesses were measured using swept source-optical coherence tomography (OCT), and multiple linear regression was used to determine which factors were associated with the thickness of each layer.
Results
The average thickness was 77.00 ± 4.78 μm (95% confidence interval [CI]: 69.56-84.56 μm) in the GCIPL, 107.68 ± 5.95 μm (95% CI: 98.45-117.21 μm) in the GCC, and 178.57 ± 9.02 μm (95% CI: 164.33-192.56 μm) in the ORL. Multiple regression analysis indicated that GCIPL thickness was associated with sex (β = 0.168, P < 0.001), age (β = 0.126, P < 0.001), axial length (β = -0.181, P < 0.001), and refractive error (β = 0.233, P < 0.001). Age (β = 0.154, P < 0.001), sex (β = 0.102, P < 0.001), and refractive error (β = 0.149, P < 0.001) were associated independently with GCC thickness after adjusting for the other factors. Furthermore, age (β = 0.100, P < 0.001), sex (β = 0.163, P < 0.001), AL (β = -0.283, P < 0.001), and refractive error (β = 0.207, P < 0.001) were the independent factors associated with ORL thickness.
Conclusions
The present study established a normative pediatric database for macular layer thicknesses in healthy Chinese children, advancing the ability of OCT in diseases diagnosis and monitoring among children.
MeSH Terms
Shields Classification
Key Concepts6
The average thickness of the macular ganglion cell-inner plexiform layer (GCIPL) in healthy Chinese children aged 6 to 19 years was 77.00 ± 4.78 μm (95% confidence interval [CI]: 69.56-84.56 μm).
The average thickness of the macular ganglion cell complex (GCC) in healthy Chinese children aged 6 to 19 years was 107.68 ± 5.95 μm (95% CI: 98.45-117.21 μm).
The average thickness of the macular outer retinal layer (ORL) in healthy Chinese children aged 6 to 19 years was 178.57 ± 9.02 μm (95% CI: 164.33-192.56 μm).
Macular ganglion cell-inner plexiform layer (GCIPL) thickness in healthy Chinese children aged 6 to 19 years was associated with sex (β = 0.168, P < 0.001), age (β = 0.126, P < 0.001), axial length (β = -0.181, P < 0.001), and refractive error (β = 0.233, P < 0.001) in a multiple regression analysis.
Macular ganglion cell complex (GCC) thickness in healthy Chinese children aged 6 to 19 years was independently associated with age (β = 0.154, P < 0.001), sex (β = 0.102, P < 0.001), and refractive error (β = 0.149, P < 0.001) after adjusting for other factors in a multiple regression analysis.
Macular outer retinal layer (ORL) thickness in healthy Chinese children aged 6 to 19 years was independently associated with age (β = 0.100, P < 0.001), sex (β = 0.163, P < 0.001), axial length (β = -0.283, P < 0.001), and refractive error (β = 0.207, P < 0.001) in a multiple regression analysis.
Related Articles5
Comparison between wide-field digital imaging system and the red reflex test for universal newborn eye screening in Brazil.
Cohort StudyRetinal and circumpapillary nerve fiber layer thickness and associated factors in children.
Cross-Sectional StudyEvaluation of the nerve fiber layer and macula in the eyes of healthy children using spectral-domain optical coherence tomography.
Case SeriesThickness of the retinal nerve fibre layer estimated with the scanning laser polarimeter in healthy children.
Observational StudyRetinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry.
Cross-Sectional StudyIs this article assigned to the wrong chapter(s)? Let us know.