The Glaucoma Italian Pediatric Study (GIPSy): The Long-term Effect of Topical Latanoprost on Central Corneal Thickness.
Riva Ivano, Galli Francesca, Biagioli Elena, Rulli Eliana, Longo Antonio, Uva Maurizio G, Oddone Francesco, Michelessi Manuele, Weinreb Robert N, Quaranta Luciano
AI Summary
This study found latanoprost treatment for pediatric glaucoma significantly increased central corneal thickness over time, particularly in younger children. This highlights a potential long-term effect to monitor.
Abstract
Precis: Central corneal thickness (CCT) may increase over time in children affected by primary congenital glaucoma and treated with latanoprost for at least 30 months.
Purpose
The purpose of this study was to investigate CCT modification over time in a population of primary pediatric glaucoma (PPG) patients prescribed a monotherapy of latanoprost.
Materials and methods
The present paper reports the results of a post hoc analysis on patients enrolled in the Glaucoma Italian Pediatric Study (GIPSy). Children affected by PPG, with a postsurgical intraocular pressure between 22 and 26 mm Hg and treated with latanoprost monotherapy for at least 30 months were eligible for the analysis. CCT variation from baseline was investigated over the follow-up using univariable and multivariable longitudinal linear mixed models. The impact of age, sex, and intraocular pressure on CCT variation were evaluated taking into account the interaction of each variable with time.
Results
Twenty-seven eyes (20 patients) were included in the analysis. Mean duration of latanoprost treatment was 36.6 months (SD 2.5) and mean CCT at baseline was 551 μm (SD 37.7). A significant increase of CCT over time was revealed by multivariable analysis, taking into account the impact of age at baseline and its interaction with time (P=0.03). The interaction between age and time was significant (P=0.04), indicating that older age at baseline was associated with lower increase of CCT over time. No variation of CCT was found in univariable analysis (P=0.28).
Conclusion
In this population of PPG patients treated with latanoprost for at least 30 months, CCT significantly increased over time, when the impact of age and its interaction with time were considered.
MeSH Terms
Shields Classification
Key Concepts5
Central corneal thickness (CCT) may increase over time in children affected by primary congenital glaucoma and treated with latanoprost for at least 30 months.
In a population of primary pediatric glaucoma (PPG) patients treated with latanoprost for at least 30 months, central corneal thickness (CCT) significantly increased over time (P=0.03) when the impact of age at baseline and its interaction with time were considered in a multivariable analysis.
In primary pediatric glaucoma (PPG) patients treated with latanoprost for at least 30 months, the interaction between age at baseline and time was significant (P=0.04), indicating that older age at baseline was associated with a lower increase of central corneal thickness (CCT) over time.
No variation of central corneal thickness (CCT) was found in a univariable analysis (P=0.28) in primary pediatric glaucoma (PPG) patients treated with latanoprost for at least 30 months.
The Glaucoma Italian Pediatric Study (GIPSy) conducted a post hoc analysis on children affected by primary pediatric glaucoma (PPG) with a postsurgical intraocular pressure between 22 and 26 mm Hg and treated with latanoprost monotherapy for at least 30 months to investigate central corneal thickness (CCT) modification over time.
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