Central corneal thickness and its associations in a Russian population. The Ural eye and Medical Study.
Bikbov Mukharram M, Gilmanshin Timur R, Zainullin Rinat M, Kazakbaeva Gyulli M, Zaynetdinov Artur F, Nuriev Ildar F, Panda-Jonas Songhomitra, Arslangareeva Inga I, Zinnatullin Ainur A, Yakupova Dilya F
AI Summary
This Russian study found CCT varied with age, sex, and ethnicity, but was unrelated to glaucoma prevalence. This highlights CCT's complex associations, impacting IOP interpretation in clinical practice.
Abstract
Background
To assess central corneal thickness (CCT) and its associations in a Russian population.
Methods
The population-based Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of an ophthalmological and general examination, CCT was measured by Scheimflug imaging.
Results
The study included 5792 (98.2%) participants (age:58.8 ± 10.6 years;range: 40-94 years) with available bilateral CCT measurements. Mean CCT was larger in Russians than non-Russians (549.5 ± 32.8 µm versus 539.2 ± 33.9 µm; P < 0.001). In multivariable analysis, thicker CCT was associated (regression coefficient r:0.43) with younger age (standardized regression coefficient beta:-0.09; non-standardized regression coefficient B:-0.29;95% confidence interval (CI):-0.39,-0.20; P < 0.001), male sex (beta:0.05; B:3.10; 95%CI:1.18,5.03; P = 0.002), urban region of habitation (beta:0.10; B:6.83; 95%CI:4.61, 9.05; P < 0.001), Russian ethnicity (beta:0.04; B:3.48; 95%CI:1.04, 5.91; P = 0.005), higher level of education (beta:0.04; B:0.97;95%CI:0.29,1.66; P = 0.006), higher serum bilirubin concentration (beta:0.05;B:0.15; 95%CI:0.07,0.23;P < 0.001), lower corneal refractive power (beta:-0.09;B:11.92; 95%CI:-2.50,-1.35; P < 0.001), smaller anterior chamber angle (beta:-0.07;B:-0.38;95%CI:-0.52,-0.24;P < 0.001), higher IOP readings (beta:0.38; B:3.47; 95%CI:3.21,3.73; P < 0.001), and higher rise in IOP readings by medical mydriasis (beta:0.07; B:0.88;95%CI:0.54,1.22;P < 0.001). In that model, CCT was not associated with body height (P = 0.14), previous cataract surgery (P = 0.10), axial length (P = 0.18) or prevalence of glaucoma (P = 0.11). The mean inter-eye difference in CCT was 8.52 ± 13.9 µm (median:6.0;95CI:8.16,8.88). A higher inter-eye CCT difference was associated with older age (beta:0.08; B:0.11;95%CI:0.07,0.15; P = 0.01), lower level of education (beta:-0.04;B:-0.34; 95%CI:-0.60,-0.08; P < 0.001) and status after cataract surgery (beta:0.04; B:2.92;95%CI:1.02,4.83; P = 0.003).
Introduction conclusions: In this ethnically mixed population from Russia with an age of 40+ years, mean CCT (541.7 ± 33.7 µm) was associated with parameters such as younger age, male sex, Russian ethnicity, and higher educational level. These associations may be taken into account when the dependence of IOP readings on CCT are considered. Glaucoma prevalence was unrelated to CCT.
MeSH Terms
Shields Classification
Key Concepts6
In a population-based Ural Eye and Medical Study, the mean central corneal thickness (CCT) was larger in Russians (549.5 ± 32.8 µm) than non-Russians (539.2 ± 33.9 µm) (P < 0.001) among 5792 participants (age: 58.8 ± 10.6 years; range: 40-94 years) with available bilateral CCT measurements.
In a multivariable analysis from the Ural Eye and Medical Study, thicker central corneal thickness (CCT) was associated with younger age (standardized regression coefficient beta: -0.09; non-standardized regression coefficient B: -0.29; 95% confidence interval (CI): -0.39, -0.20; P < 0.001) in 5792 participants.
In a multivariable analysis from the Ural Eye and Medical Study, thicker central corneal thickness (CCT) was associated with male sex (beta: 0.05; B: 3.10; 95%CI: 1.18, 5.03; P = 0.002) in 5792 participants.
In a multivariable analysis from the Ural Eye and Medical Study, thicker central corneal thickness (CCT) was associated with urban region of habitation (beta: 0.10; B: 6.83; 95%CI: 4.61, 9.05; P < 0.001) in 5792 participants.
In a multivariable analysis from the Ural Eye and Medical Study, central corneal thickness (CCT) was not associated with the prevalence of glaucoma (P = 0.11) in 5792 participants.
In a population-based Ural Eye and Medical Study, a higher inter-eye central corneal thickness (CCT) difference was associated with older age (beta: 0.08; B: 0.11; 95%CI: 0.07, 0.15; P = 0.01) among 5792 participants.
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