Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study.
Wang Jin, Liu Tingting, Li Sizhen, He Mingguang, Wang Xiaofei, Wang Ningli, Zhang Ye
AI Summary
This study found iris changes with age and sex in healthy Chinese individuals, with older age and female sex linked to smaller iris area changes, potentially explaining higher angle-closure glaucoma prevalence.
Abstract
Purpose
To determine the associations between the demographic factors (age and sex) and physiological dynamic iris changes and explore the associated factors for iris cross-sectional area (IA) change in healthy Chinese individuals.
Methods
This cross-sectional study included individuals aged ≥40 years with an open angle and underwent anterior segment optical coherence tomography under light and dark conditions from the follow-up cohort of the Handan Eye Study. Ocular data from the right eye were analyzed. The Pearson correlation coefficient was used to assess the relationship between age and iris parameters, including iris thickness (IT), IA, and iris curvature (IC), as well as the pupil diameter (PD) in the dark, and their changes from light to dark conditions. Linear regression analysis was performed to identify the potential factors associated with IA change.
Results
The final analysis included 465 healthy individuals. PD in dark, IA change and PD change decreased with age (P < 0.001), whereas IC increased with age (P < 0.001). IT and IT change were smaller, and IC was larger in women than that in men (P = 0.021, 0.007, and 0.010, respectively). Older age (P = 0.041), larger lens thickness (P = 0.013), larger IC change (P < 0.001), and smaller PD change (P < 0.001) were significantly associated with a smaller IA change.
Conclusions
Our study demonstrated the associations of static and dynamic iris parameters in healthy Chinese individuals. The findings provided a possible explanation for the higher prevalence of primary angle closure disease in elderly and female populations.
MeSH Terms
Shields Classification
Key Concepts5
In healthy Chinese individuals aged ≥40 years, pupil diameter (PD) in the dark, iris cross-sectional area (IA) change, and PD change decreased with age (P < 0.001).
In healthy Chinese individuals aged ≥40 years, iris curvature (IC) increased with age (P < 0.001).
In healthy Chinese individuals aged ≥40 years, iris thickness (IT) and IT change were smaller in women than in men (P = 0.021 and 0.007, respectively).
In healthy Chinese individuals aged ≥40 years, iris curvature (IC) was larger in women than in men (P = 0.010).
In healthy Chinese individuals aged ≥40 years, older age (P = 0.041), larger lens thickness (P = 0.013), larger iris curvature (IC) change (P < 0.001), and smaller pupil diameter (PD) change (P < 0.001) were significantly associated with a smaller iris cross-sectional area (IA) change.
Related Articles5
Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program.
Cohort StudyPrimary angle-closed diseases recognition through artificial intelligence-based anterior segment-optical coherence tomography imaging.
Cross-Sectional StudyPatterns and Disparities in Recorded Gonioscopy During Initial Glaucoma Evaluations in the United States.
Case-Control StudyInvestigating the determinants of iridolenticular contact area: a novel parameter for angle closure.
Cross-Sectional StudyDeep learning-based normative database of anterior chamber dimensions for angle closure assessment: the Singapore Chinese Eye Study.
Cross-Sectional StudyIs this article assigned to the wrong chapter(s)? Let us know.