Adrenergic and adrenolytic effects on intraocular pressure.
Drance S M, Douglas G R, Wijsman K J, Schulzer M
AI Summary
This study found combining timolol and epinephrine significantly lowers eye pressure more than either drug alone, especially long-term, offering a potential enhanced treatment for glaucoma.
Abstract
We compared the pressure-lowering effects of timolol, pindolol, epinephrine and the mixture of timolol and epinephrine with that of placebo over a 12-h period. All agents reduced the pressure significantly but with varying time courses. The mixture of timolol and epinephrine reduced the pressure significantly more than did timolol or epinephrine alone, especially at 12 h after the last administration of the drops.
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