Prelamina and Lamina Cribrosa in Glaucoma Patients With Unilateral Visual Field Loss.
Kim Dai Woo, Jeoung Jin Wook, Kim Yong Woo, Girard Michael J A, Mari Jean Martial, Kim Young Kook, Park Ki Ho, Kim Dong Myung
AI Summary
This study found that even unaffected fellow eyes in unilateral glaucoma patients show subclinical lamina cribrosa and prelaminar tissue thinning, suggesting early, pre-symptomatic changes.
Abstract
Purpose
To investigate the characteristics of the prelamina and lamina cribrosa (LC) of both eyes in glaucoma patients with unilateral visual field (VF) defect.
Methods
Forty-one subjects diagnosed with primary open-angle glaucoma with unilateral VF loss and 41 age-matched healthy control subjects were scanned by swept-source optical coherence tomography (SS-OCT). All eyes were divided into three groups: VF-affected glaucomatous eyes (group A, n = 41), perimetrically unaffected fellow eyes (group B, n = 41), and healthy control eyes (group C, n = 41). The anterior prelaminar depth (APLD) and LC depth (LCD) were measured at the center of the reference line (the Bruch's membrane opening plane). The prelaminar tissue thickness (PTT) was obtained by subtracting the APLD from the LCD. The APLD, LCD, and PTT were compared among these groups.
Results
The APLD and LCD were significantly greater in group A than in the other groups (group B, P < 0.001; group C, P < 0.001).The prelaminar tissue was significantly thinner in group A than in the other groups (group B, P = 0.007; group C, P < 0.001). Also, the prelaminar tissue was significantly thinner in group B than in group C (P = 0.003). Multivariate analysis demonstrated a significant association between PTT and initial IOP among the overall study population (P < 0.05).
Conclusions
In the fellow eyes with unilateral glaucoma patients, APLD was significantly greater, and the prelaminar tissue was significantly thinner, than in the healthy control eyes. Our findings suggest that subclinical or preperimetric changes of the LC and/or prelaminar tissue are already present in the fellow eyes with unilateral glaucoma.
MeSH Terms
Shields Classification
Key Concepts6
The anterior prelaminar depth (APLD) and lamina cribrosa depth (LCD) were significantly greater in visual field (VF)-affected glaucomatous eyes (group A, n = 41) than in perimetrically unaffected fellow eyes (group B, n = 41; P < 0.001) and healthy control eyes (group C, n = 41; P < 0.001).
The prelaminar tissue was significantly thinner in VF-affected glaucomatous eyes (group A, n = 41) than in perimetrically unaffected fellow eyes (group B, n = 41; P = 0.007) and healthy control eyes (group C, n = 41; P < 0.001).
The prelaminar tissue was significantly thinner in perimetrically unaffected fellow eyes (group B, n = 41) than in healthy control eyes (group C, n = 41; P = 0.003) in glaucoma patients with unilateral visual field loss.
Multivariate analysis demonstrated a significant association between prelaminar tissue thickness (PTT) and initial intraocular pressure (IOP) among the overall study population (P < 0.05) of glaucoma patients with unilateral visual field loss and age-matched healthy control subjects.
Subclinical or preperimetric changes of the lamina cribrosa and/or prelaminar tissue, including significantly greater anterior prelaminar depth and significantly thinner prelaminar tissue, are already present in the fellow eyes of glaucoma patients with unilateral visual field loss compared to healthy control eyes.
A cross-sectional study investigated the characteristics of the prelamina and lamina cribrosa of both eyes in 41 primary open-angle glaucoma patients with unilateral visual field loss and 41 age-matched healthy control subjects using swept-source optical coherence tomography (SS-OCT).
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