Impact of age-related macular degeneration in patients with glaucoma: understanding the patients' perspective.
Skalicky Simon E, Fenwick Eva, Martin Keith R, Crowston Jonathan, Goldberg Ivan, McCluskey Peter
AI Summary
This study found that age-related macular degeneration significantly worsens vision-related activity limitations and quality of life in glaucoma patients, particularly impacting safe mobility.
Abstract
Background
The aim of the study is to measure the impact of age-related macular degeneration on vision-related activity limitation and preference-based status for glaucoma patients.
Design
This was a cross-sectional study.
Participants
Two-hundred glaucoma patients of whom 73 had age-related macular degeneration were included in the research.
Methods
Sociodemographic information, visual field parameters and visual acuity were collected. Age-related macular degeneration was scored using the Age-Related Eye Disease Study system.
Main outcome measures
The Rasch-analysed Glaucoma Activity Limitation-9 and the Visual Function Questionnaire Utility Index measured vision-related activity limitation and preference-based status, respectively. Regression models determined factors predictive of vision-related activity limitation and preference-based status. Differential item functioning compared Glaucoma Activity Limitation-9 item difficulty for those with and without age-related macular degeneration.
Results
Mean age was 73.7 (±10.1) years. Lower better eye mean deviation (β: 1.42, 95% confidence interval: 1.24-1.63, P < 0.001) and age-related macular degeneration (β: 1.26 95% confidence interval: 1.10-1.44, P = 0.001) were independently associated with worse vision-related activity limitation. Worse eye visual acuity (β: 0.978, 95% confidence interval: 0.961-0.996, P = 0.018), high risk age-related macular degeneration (β: 0.981, 95% confidence interval: 0.965-0.998, P = 0.028) and severe glaucoma (β: 0.982, 95% confidence interval: 0.966-0.998, P = 0.032) were independently associated with worse preference-based status. Glaucoma patients with age-related macular degeneration found using stairs, walking on uneven ground and judging distances of foot to step/curb significantly more difficult than those without age-related macular degeneration.
Conclusions
Vision-related activity limitation and preference-based status are negatively impacted by severe glaucoma and age-related macular degeneration. Patients with both conditions perceive increased difficulty walking safely compared with patients with glaucoma alone.
MeSH Terms
Shields Classification
Key Concepts4
Lower better eye mean deviation (β: 1.42, 95% confidence interval: 1.24-1.63, P < 0.001) and age-related macular degeneration (β: 1.26, 95% confidence interval: 1.10-1.44, P = 0.001) were independently associated with worse vision-related activity limitation in 200 glaucoma patients, 73 of whom had age-related macular degeneration.
Worse eye visual acuity (β: 0.978, 95% confidence interval: 0.961-0.996, P = 0.018), high risk age-related macular degeneration (β: 0.981, 95% confidence interval: 0.965-0.998, P = 0.028), and severe glaucoma (β: 0.982, 95% confidence interval: 0.966-0.998, P = 0.032) were independently associated with worse preference-based status in 200 glaucoma patients, 73 of whom had age-related macular degeneration.
Glaucoma patients with age-related macular degeneration found using stairs, walking on uneven ground, and judging distances of foot to step/curb significantly more difficult than those without age-related macular degeneration in a cross-sectional study of 200 glaucoma patients, 73 of whom had age-related macular degeneration.
Vision-related activity limitation and preference-based status are negatively impacted by severe glaucoma and age-related macular degeneration.
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