Ten-year changes of intraocular pressure in adults: the Liwan Eye Study.
Han Xiaotong, Zhao Haifeng, Wu Changfan, Liu Chi, Yan William, Hu Yin, He Mingguang
AI Summary
This study found a small 10-year IOP increase in Chinese adults, positively linked to longitudinal BMI increase, highlighting BMI's role in long-term glaucoma risk.
Abstract
Importance
Understanding the longitudinal intraocular pressure (IOP) changes and potential risk factors in adults is important for future glaucoma control in the aging society.
Background
Limited longitudinal studies exist in Asia investigating the longitudinal IOP changes and with varying results.
Design
Population-based cohort study.
Participants
1405 baseline participants from the Liwan Eye Study.
Methods
All baseline participants were invited for the 10-year follow-up examination in 2013. IOP (by Tonopen), central corneal thickness (CCT; by ultrasound), refractive error (by autorefractor), blood pressure, height and weight were measured per standardized protocol and the presence of hypertension or diabetes was collected by questionnaire. Follow-up examinations were conducted using the same equipment with proper calibration. Linear regression analysis was used to assess the association between IOP change and potential risk factors.
Main outcome measures
10-year IOP change.
Results
Of the 791 participants at the 10-year follow-up, IOP data were available for 602 participants with a mean age of 60.9 years (55.5% female). The average IOP change over 10 years was an increase of 1.44 mmHg (95% confidence interval, 1.12-1.75). Linear regression showed that 10-year IOP change was not associated with baseline age, gender, body mass index (BMI), CCT, spherical equivalence (SE), hypertension or diabetes. However, it was positively associated with longitudinal increase of BMI when longitudinal changes of BMI and SE were included in the model (P < 0.001).
Conclusions and relevance: We observed a small increase in IOP over 10 years in this adult Chinese population, which was positively related to the longitudinal change in BMI.
MeSH Terms
Shields Classification
Key Concepts4
In a population-based cohort study of 602 adult Chinese participants from the Liwan Eye Study (mean age of 60.9 years, 55.5% female) with IOP data available at 10-year follow-up, the average intraocular pressure (IOP) change over 10 years was an increase of 1.44 mmHg (95% confidence interval, 1.12-1.75).
In a population-based cohort study of 602 adult Chinese participants from the Liwan Eye Study, linear regression analysis showed that the 10-year intraocular pressure (IOP) change was not associated with baseline age, gender, body mass index (BMI), central corneal thickness (CCT), spherical equivalence (SE), hypertension, or diabetes.
In a population-based cohort study of 602 adult Chinese participants from the Liwan Eye Study, linear regression analysis showed that the 10-year intraocular pressure (IOP) change was positively associated with the longitudinal increase of body mass index (BMI) when longitudinal changes of BMI and spherical equivalence (SE) were included in the model (P < 0.001).
The Liwan Eye Study is a population-based cohort study that invited 1405 baseline participants for a 10-year follow-up examination in 2013.
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