Evaluation of a Trabecular Microbypass Stent With Cataract Extraction in Severe Primary Open-angle Glaucoma.
Ferguson Tanner, Swan Russell, Ibach Mitch, Schweitzer Justin, Sudhagoni Ramu, Berdahl John P
AI Summary
This study found trabecular microbypass stents with cataract surgery safely lowered eye pressure and medication use in severe glaucoma, offering a combined treatment option.
Abstract
Purpose
To evaluate the safety and efficacy of a trabecular microbypass stent combined with cataract surgery in patients with severe open-angle glaucoma.
Patients: The series included 59 eyes with severe primary open-angle glaucoma and severe visual field loss as defined by American Academy of Ophthalmology preferred practice pattern criteria.
Materials and methods
Retrospective case series. Patients were implanted with 1 trabecular microbypass stent with concomitant cataract surgery. Primary outcome measures were intraocular pressure (IOP) and number of glaucoma medications. Safety measures included postoperative IOP pressure spikes ≥15 mm Hg or IOP<6 mm Hg at any time point, and the need for additional surgery.
Results
The mean preoperative IOP was 19.25±6.97 mm Hg. Postoperatively, the mean IOP was 14.38±3.63 mm Hg (P<0.01) at 12 months and 14.92±3.86 mm Hg (P<0.01) at 24 months. The mean number of glaucoma medications was 2.27±1.06 preoperatively and 1.63±1.17 (P<0.01) at 24 months postoperative, indicating a 28% reduction in medication use. In total, 4 (7%) eyes required additional surgery. In total, 5 eyes (8%) experienced IOP spikes ≥15 mm Hg, 14 (24%) eyes had IOP spikes ≥10 mm Hg. Overall 55% of eyes had a 20% IOP reduction after 24 months of surgery. Eyes with baseline IOP≤19 had a mean reduction of 2.24 mm Hg 36 months after surgery.
Conclusions
Trabecular microbypass stent implantation during cataract surgery safely and effectively lowers IOP and medication use in patients with severe primary open-angle glaucoma.
MeSH Terms
Shields Classification
Key Concepts6
In patients with severe primary open-angle glaucoma, a trabecular microbypass stent combined with cataract surgery resulted in a mean IOP of 14.38±3.63 mm Hg (P<0.01) at 12 months and 14.92±3.86 mm Hg (P<0.01) at 24 months postoperatively.
In patients with severe primary open-angle glaucoma, a trabecular microbypass stent combined with cataract surgery reduced the mean number of glaucoma medications from 2.27±1.06 preoperatively to 1.63±1.17 (P<0.01) at 24 months postoperative, indicating a 28% reduction in medication use.
In patients with severe primary open-angle glaucoma who received a trabecular microbypass stent combined with cataract surgery, 4 (7%) eyes required additional surgery.
In patients with severe primary open-angle glaucoma who received a trabecular microbypass stent combined with cataract surgery, 5 (8%) eyes experienced IOP spikes ≥15 mm Hg and 14 (24%) eyes had IOP spikes ≥10 mm Hg.
Trabecular microbypass stent implantation during cataract surgery safely and effectively lowers intraocular pressure and medication use in patients with severe primary open-angle glaucoma.
In patients with severe primary open-angle glaucoma, the mean preoperative intraocular pressure (IOP) was 19.25±6.97 mm Hg.
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