Keane Pearse A

Milad Daniel, Antaki Fares, Mikhail David, Farah Andrew, El-Khoury Jonathan, Touma Samir et al.

Code-free deep learning models, designed by clinicians, effectively detected glaucoma from fundus images, performing comparably to expert-built AI. This empowers clinicians to develop AI tools for broad glaucoma screening.

Chen Maggie S, Ravindranath Rohith, Chang Robert, Zhou Yukun, Keane Pearse A, Wang Sophia Y

RETFound, an AI model, accurately predicted optic nerve cup-to-disc ratio and average RNFL thickness from fundus photos. This demonstrates its potential for glaucoma screening and monitoring, even without specific prior training.

Ribeiro Reis Ana Paula, Ioannidou Estelle, Stuart Kelsey V, Wagner Siegfried K, Foster Paul J, Khawaja Anthony P et al.

This review found limited, inconsistent data on how women's hormonal cycles affect eye structures, though choroidal thinning was noted during the luteal phase. More research is needed to understand sex differences in eye diseases.

Wong Carolyn Yu Tung, Antaki Fares, Woodward-Court Peter, Ong Ariel Yuhan, Keane Pearse A

This review found saliency maps, often used to validate AI in ophthalmology, are currently not beneficial for building clinician trust due to technical limitations and superficial assessment.

Kleerekooper Iris, Wagner Siegfried K, Trip S Anand, Plant Gordon T, Petzold Axel, Keane Pearse A et al.

A new macular OCT ratio (mNTR) effectively differentiates glaucoma from chiasmal compression, offering a clinically useful tool for early diagnosis and distinguishing these conditions.

Huemer Josef, Khalid Hagar, Ferraz Daniel, Faes Livia, Korot Edward, Jurkute Neringa et al.

This study found that after diabetic optic disc swelling resolves, both diabetic papillopathy and NAION show pRNFL and mGCL thinning, but preserved mINL. This atrophy correlates with poor vision, suggesting prognostic value regardless of specific diagnosis.

von der Emde Leon, Pfau Maximilian, Holz Frank G, Fleckenstein Monika, Kortuem Karsten, Keane Pearse A et al.

AI accurately infers visual acuity and retinal sensitivity from imaging in AMD, offering potential as surrogate endpoints for future clinical trials.

Bernal-Morales Carolina, Velazquez-Villoria Daniel, Cubero-Parra Juan Manuel, Keane Pearse A, Sim Dawn A, Adán Alfredo et al.

This study found local anesthetic blocks for ocular surgery may cause paracentral acute middle maculopathy (PAMM) due to vasoconstriction or pressure, leading to vision loss. PAMM is a potential complication.

Mursch-Edlmayr Anna S, Ng Wai Siene, Diniz-Filho Alberto, Sousa David C, Arnold Louis, Schlenker Matthew B et al.

AI shows promise in diagnosing glaucoma and detecting progression using various tests, offering a future adjunct to clinical decision-making and improving care delivery and access.

Schwartz Roy, Khalid Hagar, Sivaprasad Sobha, Nicholson Luke, Anikina Evgenia, Sullivan Paul et al.

OCT and OCTA objectively assessed PDR. Structural OCT best detected new neovascularization, while B-scan OCTA excelled at monitoring regression/reactivation, improving PDR management.

Liu Xiaoxuan, Kelly Stephen R, Montesano Giovanni, Bryan Susan R, Barry Robert J, Keane Pearse A et al.

This study found glaucoma patients with uveitis experience significantly faster visual field loss than those with POAG. This highlights uveitic glaucoma as a high-risk group needing early, targeted intervention.

Mahroo Omar A, Khawaja Anthony P, Keane Pearse A

Traber Ghislaine L, Weber Konrad P, Sabah Mazen, Keane Pearse A, Plant Gordon T

This study found that larger, confluent optic nerve head drusen, visible on funduscopy/autofluorescence, are linked to visual field loss, suggesting these features predict damage.

Ko Fang, Foster Paul J, Strouthidis Nicholas G, Shweikh Yusrah, Yang Qi, Reisman Charles A et al.

This study found RPE-BM thickness varies with age, ethnicity, refraction, IOP, and smoking. IOP's association suggests relevance for glaucoma etiology, while age and smoking may impact AMD.

Alasil Tarek, Wang Kaidi, Keane Pearse A, Lee Hang, Baniasadi Neda, de Boer Johannes F et al.

SD-OCT showed normal RNFL thickness decreases with age and myopia. Caucasians had thinner RNFL than Hispanics/Asians, but sex had no effect. This guides glaucoma diagnosis by refining normative data.

Ouyang Yanling, Heussen Florian M, Keane Pearse A, Pappuru Rajeev K R, Sadda Srinivas R, Walsh Alexander C

OCT revealed juxtapapillary pigment epithelial detachments (jPEDs) in 26.1% of asymptomatic individuals, often undetected by fundus photography and increasing with age, highlighting their prevalence in the general population.

Yu Jia, Ni Yingqin, Keane Pearse A, Jiang Chunhui, Wang Wenji, Xu Gezhi

OCT revealed diverse foveomacular schisis in juvenile X-linked retinoschisis, occurring in multiple retinal layers (RNFL, INL, ONL/OPL) and locations (foveal/parafoveal), challenging prior assumptions about schisis localization.