Pfau Maximilian

Giger Jason A W, Ansari Georg, Terry Sharon F, Charbel Issa Peter, Pfau Kristina, Pfau Maximilian

This study found reliable measurement of Bruch's membrane calcification in PXE, which increases with age and strongly correlates with delayed rod-mediated dark adaptation, making it a potential early severity marker for treatment.

Wu Zhichao, Pfau Maximilian, Fleckenstein Monika, Guymer Robyn H

Studying microperimetry in AMD, researchers found truly nonresponding areas often show deep sensitivity defects (≤10 dB), not always absolute scotomas. This impacts defining end-stage AMD functionally.

Anders Philipp, Traber Ghislaine L, Pfau Maximilian, Riedl Sophie, Hagag Ahmed M, Camenzind Hanna et al.

This study compared new volumetric microperimetry metrics in intermediate AMD, finding the "total volume" metric (VTOT) better reflects retinal sensitivity than mean sensitivity, aiding future clinical trials.

Hess Kristina, Raming Kristin, Charbel Issa Peter, Herrmann Philipp, Holz Frank G, Pfau Maximilian

This study found that in patients with PXE, aging and optic nerve head drusen (ONHD) are significantly associated with ganglion cell layer (GCL) thinning, suggesting potential neuroprotective strategies.

von der Emde Leon, Pfau Maximilian, Holz Frank G, Fleckenstein Monika, Kortuem Karsten, Keane Pearse A et al.

AI accurately infers visual acuity and retinal sensitivity from imaging in AMD, offering potential as surrogate endpoints for future clinical trials.

Pfau Maximilian, Lindner Moritz, Steinberg Julia S, Thiele Sarah, Brinkmann Christian K, Fleckenstein Monika et al.

This study found mesopic/dark-adapted two-color perimetry reliably assesses retinal sensitivity in macular diseases, with Mean Deviation and Pattern Standard Deviation showing best reproducibility, revealing distinct patterns of rod/cone dysfunction.