Wu Zhichao

Sarossy Marc G, Rezk Sandy, Li Dongzhe, Hadoux Xavier, Jannaud Maxime, Coote Michael A et al.

High-resolution microperimetry better detected glaucomatous damage than standard perimetry, suggesting its potential for earlier, more precise glaucoma diagnosis due to fundus tracking and higher sampling.

Wu Zhichao, Pfau Maximilian, Fleckenstein Monika, Guymer Robyn H

Studying microperimetry in AMD, researchers found truly nonresponding areas often show deep sensitivity defects (≤10 dB), not always absolute scotomas. This impacts defining end-stage AMD functionally.

Wu Zhichao, Karunaratne Senuri, Ang Ghee Soon, Martin Keith R, Downie Laura E

This review found most glaucoma suspect guidelines are low quality, inconsistent in defining suspects and treatment initiation, highlighting gaps in evidence for predicting glaucoma and guiding treatment.

Wu Zhichao, Hadoux Xavier, Jannaud Maxime, Martin Keith R, van Wijngaarden Peter, Guymer Robyn H

Microperimetry's first test systematically underestimates visual sensitivity, especially in areas with moderate to severe loss. Excluding the initial test or using it to seed subsequent tests improves accuracy for clinical trials.

Sarossy Marc, Crowston Jonathan, Kumar Dinesh, Weymouth Anne, Wu Zhichao

Studying ERG time-frequency features improved glaucoma severity prediction compared to standard markers. This offers a new tool for assessing retinal ganglion cell dysfunction and managing glaucoma.

La Bruna Sol, Tsamis Emmanouil, Zemborain Zane Z, Wu Zhichao, De Moraes Carlos Gustavo, Ritch Robert et al.

This study compared BMO-MRW and cRNFL OCT measures in glaucoma. They mostly agreed, but disagreed in over 25% of early glaucoma cases, suggesting improvements by considering probability levels and blood vessel locations.

Wu Zhichao, Vianna Jayme R, Reis Alexandre S C, Zemborain Zane Z, Lee Seung H, Thenappan Abinaya et al.

Qualitative OCT evaluation showed no diagnostic advantage for combining BMO-MRW and cpRNFL reports over using either alone in detecting perimetric glaucoma, suggesting either is effective for experienced graders.

Wu Zhichao, Medeiros Felipe A, Weinreb Robert N, Girkin Christopher A, Zangwill Linda M

Common glaucoma visual field cluster criteria show high false-positive rates (9-46%), significantly varying by definition. Only repeatable abnormalities achieved ≤6% false positives, highlighting the need for careful criteria selection in research.

Wu Zhichao, Medeiros Felipe A, Weinreb Robert N, Zangwill Linda M

Comparing 10-2 and central 24-2 visual fields for glaucoma detection, both tests showed similar sensitivity for central abnormalities. This suggests the 10-2 test may not offer a significant advantage over central 24-2 for initial detection.

Wu Zhichao, Medeiros Felipe A

This review highlights advances in glaucoma visual field testing, showing new methods and analyses can improve progression detection, interpretation, and precision for better patient care.

Mavrommatis Maria A, Wu Zhichao, Naegele Saskia I, Nunez Jason, De Moraes Carlos Gustavo, Ritch Robert et al.

This study found deep visual field defects in glaucoma spatially correspond well with deep circumpapillary RNFL loss on OCT, improving our understanding of structure-function relationships.

Abe Ricardo Y, Diniz-Filho Alberto, Costa Vital P, Wu Zhichao, Medeiros Felipe A

This study found faster visual field loss and worse baseline vision strongly predict future vision-related disability in glaucoma patients, highlighting the importance of monitoring progression.

Wu Zhichao, Saunders Luke J, Zangwill Linda M, Daga Fábio B, Crowston Jonathan G, Medeiros Felipe A

Current OCT progression definitions for RNFL thinning show unacceptably high false-positive rates (up to 18%) in normal eyes, even accounting for aging. More stringent definitions are needed to avoid misdiagnosing glaucoma progression.

Wu Zhichao, Saunders Luke J, Daga Fábio B, Diniz-Filho Alberto, Medeiros Felipe A

This study found more frequent visual field testing (e.g., twice yearly) detects glaucoma progression faster, especially for rapid loss, offering a good balance for clinical practice.

Yarmohammadi Adeleh, Zangwill Linda M, Diniz-Filho Alberto, Saunders Luke J, Suh Min Hee, Wu Zhichao et al.

OCT-A showed reduced vessel density in both affected and seemingly healthy hemiretinae of glaucoma patients, correlating with visual field damage. This suggests OCT-A may detect early glaucoma damage.

Baig Saif, Diniz-Filho Alberto, Wu Zhichao, Abe Ricardo Y, Gracitelli Carolina P B, Cabezas Eric et al.

This study found that glaucoma patients with faster visual field loss rates are significantly more likely to report falls, highlighting the importance of monitoring progression for fall risk assessment.

Wu Zhichao, McKendrick Allison M, Hadoux Xavier, Gaskin Jennifer C Fan, Ang Ghee Soon, Sarossy Marc G et al.

Fundus-tracked perimetry variability in glaucoma depends on both sensitivity level and local gradient. This means damage uniformity affects measurement reliability, informing better monitoring.

Wu Zhichao, Jung Chang J, Ayton Lauren N, Luu Chi D, Guymer Robyn H

Microperimetry's repeatability at deep scotoma borders was worse than in normal retina, limiting its use for detecting significant functional decline in these critical areas.