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Lightman Susan L

4 articles in GJC

4 articles in GJC

1.

Macular Edema Ranibizumab versus Intravitreal Anti-inflammatory Therapy Trial: 24-Week Outcomes of Uveitic Macular Edema Re-treatment.

Gonzales John, Acharya Nisha R, Sugar Elizabeth A, Burke Alyce E, Vitale Albert T, Gupta Vishali et al.

OphthalmologyNov 20242 citationsRandomized Controlled Trial

This study found the dexamethasone implant was most effective for uveitic macular edema over 24 weeks compared to ranibizumab or methotrexate, offering a superior treatment option despite side effects.

2.

Risk of elevated intraocular pressure and glaucoma in patients with uveitis: results of the multicenter uveitis steroid treatment trial.

Friedman David S, Holbrook Janet T, Ansari Husam, Alexander Judith, Burke Alyce, Reed Susan B et al.

OphthalmologyAug 201384 citationsRandomized Controlled Trial

This study found uveitis patients treated with FA implants had a 4x higher risk of elevated IOP and glaucoma than those on systemic therapy, highlighting the need for aggressive IOP monitoring.

3.

Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IFNgamma profiles in uveitis.

Ooi Kenneth G-J, Galatowicz Grazyna, Towler Hamish M A, Lightman Susan L, Calder Virginia L

Invest Ophthalmol Vis SciJan 200672 citationsObservational Study

This study compared cytokine detection methods in uveitis aqueous humor. Multiplex arrays were more sensitive, revealing elevated IFN-gamma in active uveitis and reduced IL-5 in panuveitis, suggesting Th1 polarity with disease severity.

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