Negi Akira

Sakamoto Mari, Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

IcareONE tonometer, used by patients or doctors, showed excellent agreement with Goldmann tonometry, making it reliable for home IOP monitoring, though CCT and age can influence its readings.

Akashi Azusa, Kanamori Akiyasu, Nakamura Makoto, Fujihara Masashi, Yamada Yuko, Negi Akira

This study found SD-OCT's average cpRNFL and GCC measurements similarly diagnose highly myopic glaucoma, with RTVue showing better nasal cpRNFL detection and 3D OCT better mRNFL than Cirrus.

Akashi Azusa, Kanamori Akiyasu, Nakamura Makoto, Fujihara Masashi, Yamada Yuko, Negi Akira

This study compared three OCTs for glaucoma diagnosis, finding similar overall performance but RTVue excelled in nasal RNFL and superior GCC, offering nuanced diagnostic strengths.

Kanamori Akiyasu, Nakamura Makoto, Tomioka Mari, Kawaka Yuki, Yamada Yuko, Negi Akira

Comparing three OCTs for glaucoma, devices showed similar overall RNFL-visual field correlation, but varied retinotopic relationships. Importantly, about 60% of measured RNFL thickness is non-neuronal tissue.

Kanamori Akiyasu, Nakamura Makoto, Yamada Yuko, Negi Akira

SD-OCT effectively detects unique optic atrophy patterns in optic tract syndrome, showing distinct retinal nerve fiber and ganglion cell thinning. This aids diagnosis of this uncommon condition.

Nakamura Makoto, Ishikawa-Tabuchi Kumiko, Kanamori Akiyasu, Yamada Yuko, Negi Akira

This study found RTVue OCT outperformed Cirrus in detecting optic nerve band atrophy, especially in nasal sectors, suggesting RTVue may be more effective for diagnosing this specific condition.

Kanamori Akiyasu, Nakamura Makoto, Tomioka Mari, Kawaka Yuki, Yamada Yuko, Negi Akira

This study found that three OCT devices measure RNFL thickness differently, with Cirrus showing smaller values. Despite correlations, they are not interchangeable due to significant measurement discrepancies.

Mizokami Junji, Yamada Yuko, Negi Akira, Nakamura Makoto

This study found that larger postural IOP elevations in glaucoma patients are associated with more severe retinal nerve fiber thinning and visual field loss, suggesting postural IOP matters clinically.

Naka Maiko, Kanamori Akiyasu, Negi Akira, Nakamura Makoto

Elevated IOP in rats reduced AQP9 in the optic nerve head and retina. This suggests AQP9 dysregulation, potentially impacting metabolite transfer, contributes to glaucomatous optic neuropathy.

Kanamori Akiyasu, Naka Maiko, Fukuda Masahide, Nakamura Makoto, Negi Akira

Tafluprost, a glaucoma drug, was found to directly protect retinal ganglion cells from apoptosis in lab and animal models. This suggests it may offer neuroprotection beyond pressure lowering in glaucoma.

Naka Maiko, Kanamori Akiyasu, Tatsumi Yasuko, Fujioka Miyuki, Nagai-Kusuhara Azusa, Nakamura Makoto et al.

This study compared visual field indices (MD, AGIS, CIGTS) with structural parameters in glaucoma. It found MD was comparable to other indices for assessing functional damage, particularly in advanced stages, suggesting MD remains useful clinically.

Nagai-Kusuhara Azusa, Nakamura Makoto, Kanamori Akiyasu, Negi Akira

Glaucoma patients with hemifield defects showed optic disc damage even in "unaffected" areas, and structural-functional correlation wasn't linear, highlighting complex disease progression.

Shibuya Etsuko, Meguro Akira, Ota Masao, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki et al.

This study found specific variations in the TLR4 gene are associated with an increased risk of normal tension glaucoma, suggesting immune pathways may contribute to the disease.

Nagai-Kusuhara A, Nakamura M, Kanamori A, Nakanishi Y, Kusuhara S, Negi Akira

HRT effectively assessed optic nerve head configuration in NAION and LHON, but caution is needed when interpreting parameters in compressive optic neuropathy due to atypical changes.

Inatani Masaru, Iwao Keiichiro, Kawaji Takahiro, Hirano Yoshio, Ogura Yuichiro, Hirooka Kazuyuki et al.

This study found younger age, higher baseline IOP, intravitreal injection, and increased triamcinolone dosage are key risk factors for steroid-induced IOP elevation.

Nagai-Kusuhara Azusa, Nakamura Makoto, Fujioka Miyuki, Negi Akira

Amniotic membrane transplantation (AMT) successfully treated intractable late-onset leaking blebs long-term in this study, offering a promising revision technique for this glaucoma surgery complication.

Tatsumi Yasuko, Nakamura Makoto, Fujioka Miyuki, Nakanishi Yoriko, Kusuhara Azusa, Maeda Hidetaka et al.

This study found that a detectable RAPD in asymmetric glaucoma correlates with significant RNFL thinning, averaging 73% in the more affected eye, aiding clinical damage assessment.

Nakanishi Yoriko, Nakamura Makoto, Tatsumi Yasuko, Nagai-Kusuhara Azusa, Negi Akira

This study found a relative afferent pupillary defect (RAPD) in humans requires approximately 25% retinal nerve fiber layer loss, confirming significant nerve damage before clinical detection.

Nakamura Makoto, Darhad Urtogtah, Tatsumi Yasuko, Fujioka Miyuki, Kusuhara Azusa, Maeda Hidetaka et al.

iCare rebound tonometer's IOP measurements generally agree well with other tonometers, but thicker corneas cause iCare to significantly overestimate Goldmann and Tonopen readings, impacting clinical accuracy.

Kanamori Akiyasu, Nagai-Kusuhara Azusa, Escaño Michael F T, Maeda Hidetaka, Nakamura Makoto, Negi Akira

This study compared CSLO, SLP, and OCT for early glaucoma detection. SLP and OCT showed superior ability over CSLO to discriminate glaucoma suspects and early glaucoma, offering better diagnostic utility.

Kanamori Akiyasu, Nakamura Makoto, Matsui Noriko, Nagai Azusa, Nakanishi Yoriko, Kusuhara Sentaro et al.

OCT detected characteristic horizontal RNFL thinning in band atrophy caused by chiasmal compression, correlating with visual field loss, demonstrating its utility for identifying this specific glaucoma pattern.

Kanamori Akiyasu, Nakamura Makoto, Matsui Noriko, Tomimori Hiroko, Tanase Makiko, Seya Ryu et al.

Goniosynechialysis with lens aspiration effectively treated spherophakia-related glaucoma in a teenager, restoring outflow and controlling IOP long-term, demonstrating a safe and effective surgical approach.

Nakamura Makoto, Kanamori Akiyasu, Seya Ryu, Maeda Hidetaka, Negi Akira

This case found occult macular dystrophy caused central vision loss in a normal-tension glaucoma patient, despite a normal-looking macula. Clinicians should investigate other causes for unexplained central vision loss in NTG.

Kanamori Akiyasu, Nakamura Makoto, Escano Michael F T, Seya Ryu, Maeda Hidetaka, Negi Akira

OCT-measured RNFL thickness effectively detects early glaucoma damage, with inferotemporal RNFL showing the best diagnostic ability, providing valuable information for monitoring glaucomatous changes.

Tsukamoto Hidetoshi, Mishima Hiromu K, Kitazawa Yoshiaki, Araie Makoto, Abe Haruki, Negi Akira

This study compared latanoprost and unoprostone for glaucoma/ocular hypertension, finding latanoprost significantly lowered intraocular pressure more effectively, offering superior IOP control for patients.