Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts.
Lee Shanjean, Sheck Leo, Crowston Jonathan G, Van Bergen Nicole J, O'Neill Evelyn C, O'Hare Fleur et al.
POAG patient lymphoblasts showed impaired mitochondrial complex-I function, reducing ATP synthesis and respiration. This suggests systemic bioenergetic defects that could increase retinal ganglion cell vulnerability in glaucoma.