Wang Bingrui

Lu Yuankai, Hua Yi, Wang Bingrui, Tian Qi, Zhong Fuqiang, Theophanous Andrew et al.

This study found that elevated IOP distorts the lamina cribrosa, significantly reducing its oxygenation and causing hypoxia. This suggests IOP-induced distortions contribute to glaucomatous nerve damage.

Bansal Manik, Wang Bingrui, Waxman Susannah, Zhong Fuqiang, Hua Yi, Lu Yuankai et al.

This study developed an axon-centric method to analyze IOP-induced mechanical insult. It found axons experience distinct, orientation-specific compression/stretch in different optic nerve head regions, unlike tissue-level strains, offering new insights into glaucoma damage.

Lu Yuankai, Hua Yi, Wang Bingrui, Zhong Fuqiang, Theophanous Andrew, Tahir Shaharoz et al.

This study simulated lamina cribrosa vessel collapse under high eye pressure. It found blood flow was sensitive to distributed collapse, while oxygenation was robust to it but vulnerable to clustered collapse.

Ji Fengting, Islam Mohammad R, Wang Bingrui, Hua Yi, Sigal Ian A

Monkey eye research found anterior lamina cribrosa insertions are sparser, narrower, and more slanted. This suggests weaker support, potentially explaining regional glaucoma susceptibility and LC deepening.

Wei Junchao, Hua Yi, Yang Bin, Wang Bo, Schmitt Samantha E, Wang Bingrui et al.

This study compared acute IOP-induced lamina cribrosa deformation premortem vs. postmortem. Deformations were overall smaller postmortem, but varied locally, suggesting postmortem models may underestimate in-vivo biomechanics.

Voorhees Andrew P, Hua Yi, Brazile Bryn L, Wang Bingrui, Waxman Susannah, Schuman Joel S et al.

This study found that missing lamina cribrosa tissue (defects) can *reduce* IOP-induced neural tissue strain, challenging the idea that defects are always detrimental. Partial tissue loss was biomechanically worse than complete loss.