Xu Benjamin Y

Deep Learning Classifiers for Automated Detection of Gonioscopic Angle Closure Based on Anterior Segment OCT Images.

Deep learning classifiers effectively detect gonioscopic angle closure and PACD based on automated analysis of AS-OCT images.

Ocular Biometric Risk Factors for Progression of Primary Angle Closure Disease: The Zhongshan Angle Closure Prevention Trial.

Ocular biometric measurements can help to risk-stratify patients with early angle closure for more severe disease.

Anatomic Changes and Predictors of Angle Widening after Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial.

Superior LPI location results in significantly greater angle widening compared with temporal or nasal locations in a Chinese population with PACS. This supports consideration of superior LPI locations to optimize anatomic changes after LPI.

Deep Neural Network for Scleral Spur Detection in Anterior Segment OCT Images: The Chinese American Eye Study.

A deep neural network can detect the scleral spur on AS-OCT images with performance similar to that of a human expert grader.

Correlation between Intraocular Pressure and Angle Configuration Measured by OCT: The Chinese American Eye Study.

There is an anatomic threshold for angle configuration below which IOP is strongly related to the degree of angle closure.

Identifying, Understanding, and Addressing Disparities in Glaucoma Care in the United States.

By recognizing underlying causes and proposing potential solutions, healthcare providers, policymakers, and other stakeholders can work collaboratively to reduce the burden of glaucoma and improve visual health and clinical outcomes in vulnerable patient populations.

Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.

Age, sex, and systemic influences, such as diabetes duration, need to be considered when assessing changes in RPC VD in glaucoma and other ocular diseases.

Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study.

A multi-image approach should be the standard in OCT-based studies of AOD, ARA, TISA, TIA, SSAngle, IA, and LV.

A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy.

Both techniques of MMC delivery (subconjunctival injection and direct scleral application) resulted in comparable surgical outcomes and bleb morphologies.

Ocular Biometric Determinants of Anterior Chamber Angle Width in Chinese Americans: The Chinese American Eye Study.

ACD, LV, and IC are the strongest determinants of angle width in Chinese Americans.

Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography.

Angle assessments by gonioscopy and EyeCam are weakly related to angle dimensions in eyes with angle closure.

Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries.

Parameters from 4.5 scans generally outperformed those from 6.0 scans in the global and quadrant regions, suggesting greater digital resolution in 4.5 scans of the immediate peripapillary RPC is important in detecting glaucomatous changes.

Biometric Risk Factors for Angle Closure Progression After Laser Peripheral Iridotomy.

Study results suggest that persistent angle narrowing detected by AS-OCT or cumulative gonioscopy score was predictive of disease progression in PACS eyes after LPI.

Glaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study.

A CNN classifier can effectively detect angle closure in goniophotographs with performance comparable to that of an experienced glaucoma specialist.

A Mechanistic Model of Aqueous Humor Flow to Study Effects of Angle Closure on Intraocular Pressure.

IOP increases rapidly when the circumferential extent of angle closure exceeds 180°. Residual AH outflow may explain why not all angle closure eyes develop elevated IOP when angle closure is extensive.

Differences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study.

Differences in biometric measurements between subtypes of PACD eyes were small in a population-based cohort of Chinese Americans.

Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

hdVAD is higher in early glaucoma and may help with early detection when damage is focal, but its diagnostic ability appears less robust in advanced glaucoma when damage is diffuse.

Ocular Biometric Determinants of Dark-to-Light Change in Angle Width: The Chinese American Eye Study.

Beneficial angle widening effects of transitioning from dark to light are attenuated in eyes with PACD, which appears related to aberrant dark-to-light change in ACW.

Effect of Angle Narrowing on Sectoral Variation of Anterior Chamber Angle Width: The Chinese American Eye Study.

Correlations between mean and sectoral variation of ACA width strengthen as the severity of angle narrowing worsens.

Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma.

pPD, mVAD, and mVSD had approximately 4 steps within their dynamic ranges, without true measurement floors, and thus may be useful in evaluating advanced glaucomatous progression.

Relationship Between Glaucoma and Chronic Stress Quantified by Allostatic Load Score in the All of Us Research Program.

AoU participants with glaucoma had greater AL 6.4 years before diagnosis, and the AL score partially mediated racial or ethnic differences in glaucoma risk.

Long-Term Risk and Prediction of Progression in Primary Angle Closure Suspect.

This cohort study suggests that higher IOP, shallower central and limbal ACDs, and smaller TISA at 500 μm and light-room ARA at 750 μm may serve as baseline predictors for progression to PAC in PACS eyes.

Refractive Error and Anterior Chamber Depth as Risk Factors in Primary Angle Closure Disease: The Chinese American Eye Study.

The risk of PACD rises rapidly with greater hyperopia while remaining relatively low for all degrees of myopia.

Federated Learning in Glaucoma: A Comprehensive Review and Future Perspectives.

Federated Learning presents a promising strategy to overcome current obstacles in developing AI models for glaucoma screening.

Racial and Ethnic Differences in the Roles of Myopia and Ocular Biometrics as Risk Factors for Primary Open-Angle Glaucoma.

Although the POAG risk conferred by myopic RE and longer AL is similar between Latino and Chinese Americans, the difference in POAG prevalence between the two groups is narrowed by higher myopia prevalence among Chinese Americans.

Short-Term Ocular Biometric Changes as Predictors of Long-Term Angle Closure Progression.

Short-term (18-month) changes in LV and TISA750 were associated with long-term (36-72 month) angle closure progression in untreated PACS eyes, suggesting that monitoring changes in lens size or position and angle width could augment predictive…

Prevalence and Risk Factors of Primary Angle Closure Disease in an Adult Chinese American Population: The Chinese American Eye Study.

PACG prevalence was not substantially lower among Chinese Americans compared to mainland Chinese.

Role of Static and Dynamic Ocular Biometrics Measured in the Dark and Light as Risk Factors for Angle Closure Progression.

Static parameters measured in the light are as predictive, and possibly more so, of angle closure progression as those measured in the dark.

Repeatability and Reproducibility of 4.5 by 4.5 mm Peripapillary Optical Coherence Tomography Angiography Scans in Glaucoma and Non-Glaucoma Eyes.

Among nonglaucomatous and glaucomatous eyes, the majority of peripapillary OCTA vessel parameters from 4.5×4.5 mm scans had greater intrasession repeatability than intersession reproducibility.

Wedge Defects on Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma: Prevalence and Associated Clinical Factors.

DH history and paracentral VF defects were independently associated with wedge defects on OCTA, which was present in 45.3% of primary open-angle glaucoma patients. These findings may provide insight into glaucoma pathogenesis.

Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma.

The finding of an association between macular VD and TRBF supports the role of vascular factors in the pathophysiology of POAG and potential conduct of future studies aimed at identifying multiple image-based vascular metrics for…

Gap Analysis of Glaucoma Examination Concept Representations within Standard Systemized Nomenclature of Medicine - Clinical Terms.

There are existing gaps in the standardized representation of findings related to tonometry and gonioscopy within SNOMED-CT.

Age-Related Changes in Dynamic Iris Behavior Assessed Using a Programmable Closed-Loop Iris Control System.

A programmable closed-loop iris control system can modulate dynamic iris behavior and maintain the iris in a mid-dilated position. Pupillary constriction velocity and iris activity in the mid-dilated position decrease with age.

Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program.

AAC risk was less than 1 in 40 000 per dilation in a high-volume TDRS program serving a diverse safety net population, supporting the overall safety of dilation in this setting.

Gap Analysis of Standard Automated Perimetry Concept Representation in Medical Terminologies.

There is a lack of representation of some SAP data elements in standardized medical terminologies, hampering interoperability and data sharing.

Classification of Angle Closure Severity by Hierarchical Cluster Analysis of Ocular Biometrics in the Dark and Light.

Unsupervised cluster analysis of ocular biometrics can classify angle closure eyes by severity. Static biometrics measured in the light and dark are both predictive of PAC/G.

Detection of Nonglaucomatous Macula Findings With Ganglion Cell Analysis Printouts vs Full Macular Cube Scans.

The findings indicate that nonglaucomatous macular pathology may be missed based on GCA printouts alone.

Safety of Pharmacologic Dilation: Incidence and Risk Factors of Acute Angle Closure in a Nationwide Cohort.

In a nationwide cohort, the risk of AAC diagnosis following dilation ranged from around 1 in 7,000 to 26,000 dilations.

Ocular Biometric Predictors of Corneal Endothelial Contact by Intracameral Implants for Open-Angle Glaucoma and Ocular Hypertension.

CEC by a simulated intracameral implant was predicted in a subset of patients with chart diagnosis of POAG or OHTN. AS-OCT biometrics were more strongly predictive of CEC than gonioscopy.

Prevalence and Risk Factors of Open-Angle Glaucoma in an Adult Chinese American Population: The Chinese American Eye Study.

The prevalence of OAG among Chinese Americans may be higher than that reported in US populations of European descent and in Asia-based Chinese populations, but lower than that observed in Latinos in Los Angeles and individuals of African Caribbean descent.

Longitudinal Trends in Resource Utilization Associated With Newly Diagnosed Primary Angle Closure Glaucoma in the United States.

Costs associated with newly diagnosed PACG were found to be disproportionately driven by a small subset of cases.

Novel hyperparallel optical coherence tomography for angle closure assessment: comparison with swept-source OCT and gonioscopy.

HP-OCT showed excellent reproducibility for angle closure assessment and good agreement with SS-OCT and gonioscopy.

Investigating the determinants of iridolenticular contact area: a novel parameter for angle closure.

ILCA is a significant predictor of angle closure independent of other biometric factors and may reflect unique anatomical information associated with pupillary block. ILCA represents a novel biometric risk factor in eyes with angle closure.

Automated expert-level scleral spur detection and quantitative biometric analysis on the ANTERION anterior segment OCT system.

DL algorithms on the ANTERION approximate expert-level measurement of scleral spur-based biometric parameters in an independent patient population.