Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography.
Gao Kai, Song Shaozhen, Johnstone Murray A, Zhang Qinqin, Xu Jingjiang, Zhang Xiulan, Wang Ruikang K, Wen Joanne C
AI Summary
PhS-OCT showed glaucoma eyes have reduced pulsatile trabecular meshwork motion, suggesting altered tissue stiffness. This measure could help characterize outflow pathway abnormalities in glaucoma.
Abstract
Purpose
The purpose of this study was to investigate the difference in pulsatile trabecular meshwork (TM) motion between normal and eyes with POAG using phase-sensitive optical coherence tomography (PhS-OCT).
Methods
In this cross-sectional study, eight healthy subjects (16 eyes) and nine patients with POAG (18 eyes) were enrolled. A laboratory-based prototype PhS-OCT system was used to measure pulsatile TM motion. PhS-OCT images were analyzed to obtain parameters of pulsatile TM motion (i.e. maximum velocity [MV] and cumulative displacement [CDisp]). Outflow facility and ocular pulse amplitude were measured using pneumotonography. Detection sensitivity was compared among various parameters by calculating the area under the receiver operating characteristic curves (AUCs).
Results
A pulsatile TM motion waveform synchronous with digital pulse was observed using PhS-OCT in both healthy and POAG eyes. The mean MV in eyes with glaucoma was significantly lower than healthy eyes (P < 0.001). The mean CDisp in POAG eyes was also significantly lower than healthy eyes (P < 0.001). CDisp showed a significant correlation (r = 0.46; P = 0.0088) with ocular pulse amplitude in the study. Compared with the outflow facility, both the MV and CDisp were found to have a better discrimination of glaucoma (P < 0.001 and P = 0.0074, respectively).
Conclusions
Pulsatile TM motion was reduced in patients with POAG compared to healthy subjects. The underlying mechanism may be due to the altered tissue stiffness or other biomechanical properties of the TM in POAG eyes. Our evidence suggests that the measurement of pulsatile TM motion with PhS-OCT may help in characterizing outflow pathway abnormalities.
MeSH Terms
Shields Classification
Key Concepts6
The mean maximum velocity (MV) of pulsatile trabecular meshwork (TM) motion in eyes with primary open angle glaucoma (POAG) was significantly lower than in healthy eyes (P < 0.001) as measured by phase-sensitive optical coherence tomography (PhS-OCT).
The mean cumulative displacement (CDisp) of pulsatile trabecular meshwork (TM) motion in eyes with primary open angle glaucoma (POAG) was significantly lower than in healthy eyes (P < 0.001) as measured by phase-sensitive optical coherence tomography (PhS-OCT).
Both maximum velocity (MV) and cumulative displacement (CDisp) of pulsatile trabecular meshwork (TM) motion, measured by phase-sensitive optical coherence tomography (PhS-OCT), demonstrated better discrimination of primary open angle glaucoma (P < 0.001 and P = 0.0074, respectively) compared with outflow facility.
A pulsatile trabecular meshwork (TM) motion waveform synchronous with digital pulse was observed using phase-sensitive optical coherence tomography (PhS-OCT) in both healthy eyes (16 eyes) and primary open angle glaucoma (POAG) eyes (18 eyes).
Cumulative displacement (CDisp) of pulsatile trabecular meshwork (TM) motion showed a significant correlation (r = 0.46; P = 0.0088) with ocular pulse amplitude in a cross-sectional study of 17 subjects (8 healthy, 9 with POAG).
The measurement of pulsatile trabecular meshwork (TM) motion with phase-sensitive optical coherence tomography (PhS-OCT) may help in characterizing outflow pathway abnormalities in patients with primary open angle glaucoma.
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