Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study.
Tun Tin A, Wang Xiaofei, Baskaran Mani, Nongpiur Monisha Esther, Tham Yih Chung, Nguyen Duc Quang, Strouthidis Nicholas G, Aung Tin, Cheng Ching-Yu, Boote Craig
AI Summary
This study found lamina cribrosa depth varies by age, gender, race, and ocular factors in healthy Asians. This normative data aids more accurate glaucoma assessment via OCT.
Abstract
Aim
To investigate the determinants of lamina cribrosa depth (LCD) in healthy eyes of Chinese and Indian Singaporean adults.
Methods
The optic nerve head (ONH) of the right eye of 1396 subjects (628 Chinese and 768 Indian subjects) was imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). LCD was defined as the distance from the Bruch's membrane opening (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface. A linear regression model was used to evaluate the relationship between the LCD and its determinants.
Results
Both LCDs were significantly different between the two races (LCD-BMO: 421.95 (95% CI 365.32 to 491.79) µm in Chinese vs 430.39 (367.46-509.81) µm in Indians, p=0.021; and LCD-PPS: 353.34 (300.98-421.45) µm in Chinese vs 376.76 (313.39-459.78) µm in Indians, p<0.001). In the multivariable regression analysis, the LCD-PPS of the whole cohort was independently associated with females (β=-31.93, p<0.001), Indians subjects (β=21.39, p=0.004) (Chinese as the reference), axial length (Axl) (β=-6.68, p=0.032), retinal nerve fibre layer thickness (RNFL) (β=0.71, p=0.019), choroidal thickness (ChT) (β=0.41, p<0.001), vertical cup disc ratio (VCDR) (β=24.42, p<0.001) and disc size (β=-60.75, p=0.001). For every 1 year older in age, the LCD-PPS was deeper on average by 1.95 µm in Chinese subjects (p=0.01) but there was no association in Indians subjects (p=0.851).
Conclusions
The LCD was influenced by age, gender, race, Axl, RNFL, ChT, VCDR and disc size. This normative LCD database may facilitate a more accurate assessment of ONH cupping using OCT in Asian populations.
MeSH Terms
Shields Classification
Key Concepts4
In healthy eyes of Chinese and Indian Singaporean adults, lamina cribrosa depth (LCD) measured from Bruch's membrane opening (LCD-BMO) was 421.95 m (95% CI 365.32 to 491.79) in Chinese subjects and 430.39 m (367.46-509.81) in Indian subjects, with a statistically significant difference between the two races (p=0.021).
In healthy eyes of Chinese and Indian Singaporean adults, lamina cribrosa depth (LCD) measured from the peripapillary sclera (LCD-PPS) was 353.34 m (95% CI 300.98 to 421.45) in Chinese subjects and 376.76 m (313.39-459.78) in Indian subjects, with a statistically significant difference between the two races (p<0.001).
In a multivariable regression analysis of a cohort of 1396 healthy Chinese and Indian Singaporean adults, lamina cribrosa depth measured from the peripapillary sclera (LCD-PPS) was independently associated with females (=-31.93, p<0.001), Indian subjects (=21.39, p=0.004) (with Chinese as reference), axial length (=-6.68, p=0.032), retinal nerve fibre layer thickness (=0.71, p=0.019), choroidal thickness (=0.41, p<0.001), vertical cup disc ratio (=24.42, p<0.001), and disc size (=-60.75, p=0.001).
In healthy Chinese Singaporean adults, lamina cribrosa depth measured from the peripapillary sclera (LCD-PPS) was deeper on average by 1.95 m for every 1 year older in age (p=0.01), but this association was not observed in healthy Indian Singaporean adults (p=0.851).
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