Angle-closure glaucoma in East Asian and European people. Different diseases?
He M, Foster P J, Johnson G J, Khaw P T
AI Summary
East Asians have higher, often asymptomatic, angle-closure glaucoma prevalence than Europeans, likely due to anatomical differences, but research limitations hinder understanding of mechanisms and natural history.
Abstract
In contrast to the pattern of disease in Europeans, primary angle closure has a higher prevalence and tends to be asymptomatic in East Asians. The higher prevalence is attributed to differences in anterior chamber and angle anatomy. Several studies suggest that central anterior chamber depth is shallower in East Asians than in Europeans, although this is not universally accepted. It is debated whether pupil block is the predominant mechanism of angle closure in Asian people. Meaningful comparison between studies is currently hindered by differences in patient selection, examination technique, and case definition; however, the major scientific deficiency is the paucity of prospective followup data to give an insight into natural history of the disease. This review examines the data on prevalence, risk factors, and mechanism of angle closure. Special consideration is given to limitations of methodology in research to date, with the intention of developing more robust data in future studies.
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