Development of angle closure and associated risk factors: The Handan eye study.
Zhang Ye, Zhang Qing, Thomas Ravi, Li Si Zhen, Wang Ning Li
AI Summary
This study found that shallower anterior chamber depth and narrower angle width predict the development of angle closure from an open angle in a rural Chinese population, highlighting key risk factors for progression.
Abstract
Purpose
To investigate the development of angle closure from baseline open angle and associated risk factors in a rural Chinese population through a longitudinal study over a 5-year period.
Methods
Subjects aged ≥30 years and older with bilateral open angles at baseline of the Handan Eye Study who participated in the follow-up and had undergone both baseline and follow-up gonioscopic examinations were included. Subjects with any form of angle closure, glaucoma, incisional ocular surgery or other conditions that could influence the results were excluded. The development of angle closure was defined as the presence of primary angle closure suspect (PACS) or primary angle closure (PAC)/primary angle closure glaucoma (PACG) during the follow-up in normal subjects with baseline bilateral open angles. Logistic regression was performed to identify the baseline risk factors for the development of angle closure.
Results
A total of 457 subjects with bilateral open angles at baseline aged 53.0 (45.5, 58.0) years were enrolled. 94.7% of the included cases developed PACS, 5.3% developed PAC and no one developed PACG after 5 years. In logistic regression, significant risk factors for the development of angle closure were shallower central anterior chamber depth (ACD) (p = 0.002) and narrower mean angle width (p < 0.001).
Conclusions
This study reports the development from baseline open angle to angle closure after a 5-year follow-up. We confirm that the mean angle width and central ACD were independent predictive risk factors for the development of any form of angle closure.
MeSH Terms
Shields Classification
Key Concepts4
In a rural Chinese population, 94.7% of subjects with bilateral open angles at baseline developed primary angle closure suspect (PACS) after 5 years, while 5.3% developed primary angle closure (PAC), and no one developed primary angle closure glaucoma (PACG).
In a rural Chinese population, shallower central anterior chamber depth (ACD) (p = 0.002) was a significant risk factor for the development of angle closure from baseline open angle over a 5-year period.
In a rural Chinese population, narrower mean angle width (p < 0.001) was a significant risk factor for the development of angle closure from baseline open angle over a 5-year period.
The mean angle width and central anterior chamber depth (ACD) were independent predictive risk factors for the development of any form of angle closure in a rural Chinese population over a 5-year follow-up.
Related Articles5
Progression of Primary Angle Closure Suspect to Primary Angle Closure and Associated Risk Factors: The Handan Eye Study.
Cohort StudyFifteen-Year Incidence Rate of Primary Angle Closure Disease in the Andhra Pradesh Eye Disease Study.
Cohort StudyCorrelation of previous acute angle-closure attack with extent of synechial angle closure in chronic primary angle-closure glaucoma patients.
Cohort StudyAngle-closure glaucoma in East Asian and European people. Different diseases?
ReviewFive-year incidence of angle closure among glaucoma health examination participants.
Cohort StudyIs this article assigned to the wrong chapter(s)? Let us know.