A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes.
Thakku Sri Gowtham, Tham Yih-Chung, Baskaran Mani, Mari Jean-Martial, Strouthidis Nicholas G, Aung Tin, Cheng Ching-Yu, Girard Michael J A
AI Summary
This study developed a new lamina cribrosa shape index (LC-GSI). A more prominent central ridge (larger LC-GSI) was linked to shorter axial length and smaller VCDR, suggesting its potential role in glaucoma risk assessment.
Abstract
Purpose
Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape in vivo exists. We aim to introduce a new global shape index for the anterior LC (LC-GSI) and to identify associations with ocular factors in a healthy Indian population.
Methods
Optical coherence tomography (OCT) scans of the optic nerve head (ONH) were performed on 162 healthy subjects. Optic nerve head structures were delineated and a geometric characterization of anterior LC morphology was obtained by measuring curvature along 180 LC cross sections and representing it as LC-GSI ranging from -1 to +1. Lamina cribrosa depth and curvature were also reported. Linear regression was used to identify factors associated with LC morphology.
Results
The typical healthy LC had a saddle rut-like appearance, with a central ridge visible in superior-inferior cross sections. A more prominent central ridge (larger LC-GSI) was associated with shorter axial length (P < 0.001), smaller Bruch's membrane opening (BMO) area (P = 0.020), smaller vertical cup-to-disc ratio (VCDR) (P = 0.007), and larger minimum rim width (BMO-MRW) (P = 0.001). A deeper LC was associated with male sex (P < 0.001), shorter axial length (P = 0.003), larger VCDR (P < 0.001), and smaller BMO-MRW (P = 0.002). Age and IOP were not significantly associated with LC morphology in healthy eyes.
Conclusions
The LC-GSI is a single index that quantifies overall LC shape in an intuitive way. Ocular determinants of LC-GSI in healthy eyes included risk factors for glaucoma (axial length, VCDR, and BMO-MRW), highlighting the potential role of LC morphological characterization in the diagnosis and monitoring of glaucoma.
MeSH Terms
Shields Classification
Key Concepts4
A more prominent central ridge (larger LC-GSI) in healthy Indian eyes was associated with shorter axial length (P < 0.001), smaller Bruch's membrane opening (BMO) area (P = 0.020), smaller vertical cup-to-disc ratio (VCDR) (P = 0.007), and larger minimum rim width (BMO-MRW) (P = 0.001).
A deeper lamina cribrosa (LC) in healthy Indian eyes was associated with male sex (P < 0.001), shorter axial length (P = 0.003), larger vertical cup-to-disc ratio (VCDR) (P < 0.001), and smaller minimum rim width (BMO-MRW) (P = 0.002).
Age and intraocular pressure (IOP) were not significantly associated with lamina cribrosa (LC) morphology in healthy Indian eyes.
The Lamina Cribrosa Global Shape Index (LC-GSI) is a single index that quantifies overall lamina cribrosa (LC) shape and was introduced in a study of healthy Indian eyes.
Related Articles5
Association of Optic Nerve Head Metrics and Parapapillary Gamma Zone With Myopia Onset and Progression in Children: The Hong Kong Children Eye Study.
Cohort StudyPredicting Retinal Nerve Fiber Layer Thickness From Ocular Hypertension Treatment Study Optic Disc Photographs.
Cohort StudyPhysiological change in ganglion cell inner plexiform layer and nerve fibre layer thickness over six years.
Cohort StudyOcular blood flow biomarkers may predict long-term glaucoma progression.
Cohort StudyInitial Retinal Nerve Fiber Layer Loss and Risk of Diabetic Retinopathy Over a Four-Year Period.
Cohort StudyIs this article assigned to the wrong chapter(s)? Let us know.