Jeffrey M. Liebmann

Hybrid Deep Learning on Single Wide-field Optical Coherence tomography Scans Accurately Classifies Glaucoma Suspects.

The HDLM protocol outperforms standard OCT and VF clinical metrics in distinguishing healthy suspect eyes from eyes with early glaucoma.

24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma.

Central visual field damage seen on the 10-2 test is often missed with the 24-2 strategy in all groups. This finding has implications for the diagnosis of glaucoma and classification of severity.

Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma.

In this paper we provide an analysis based on the existing literature to support the hypothesis that decreasing the rate of visual field progression by 30% in a trial lasting 12-18 months is clinically meaningful.

Deep Learning Approaches Predict Glaucomatous Visual Field Damage from OCT Optic Nerve Head En Face Images and Retinal Nerve Fiber Layer Thickness Maps.

Deep learning models had high accuracy in identifying eyes with GFVD and predicting the severity of functional loss from SD OCT images.

Oral Memantine for the Treatment of Glaucoma: Design and Results of 2 Randomized, Placebo-Controlled, Phase 3 Studies.

With technologies available when the studies were conducted, daily treatment with memantine over 48 months was not shown to prevent glaucomatous progression in this patient population.

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.

A combination of nicotinamide and pyruvate yielded significant short-term improvement in visual function, supporting prior experimental research suggesting a role for these agents in neuroprotection for individuals with glaucoma and confirming the need for long-term…

Association Between Undetected 10-2 Visual Field Damage and Vision-Related Quality of Life in Patients With Glaucoma.

The 10-2 VF model showed a stronger association with NEI VFQ-25 score than the 24-2 VF model.

Detecting glaucoma with only OCT: Implications for the clinic, research, screening, and AI development.

In section 5, the model helps account for the success of an AI deep learning model, which in turn validates our focus on the RNFL p-map.

Latanoprostene Bunod 0.024% in Subjects With Open-angle Glaucoma or Ocular Hypertension: Pooled Phase 3 Study Findings.

In this pooled analysis of subjects with OAG and OHT, LBN 0.024% qd provided greater IOP-lowering compared with timolol 0.5% bid and maintained lowered IOP through 12 months.

A Single Wide-Field OCT Protocol Can Provide Compelling Information for the Diagnosis of Early Glaucoma.

A single-page report based upon a single, wide-field OCT scan has the information needed to diagnose early glaucoma with excellent sensitivity/specificity.

Association Between 24-Hour Intraocular Pressure Monitored With Contact Lens Sensor and Visual Field Progression in Older Adults With Glaucoma.

Results of this study indicate that 24-hour CLS recordings may be associated with prior rates of visual field progression of glaucoma.

Detection of Glaucoma Progression in Individuals of African Descent Compared With Those of European Descent.

Patients of African descent with glaucoma showed increased visual field variability compared with those of European descent, resulting in delayed detection of progression that may contribute to explain higher rates of glaucoma-related visual impairment in…

Structure-Function Agreement Is Better Than Commonly Thought in Eyes With Early Glaucoma.

There is good agreement between structural and functional damage, even in eyes with confirmed early glaucomatous damage, if both 24-2 and 10-2 VFs are obtained, and abnormal locations on the VFs are compared to abnormal regions seen on OCT macular and disc scans.

Effects of Study Population, Labeling and Training on Glaucoma Detection Using Deep Learning Algorithms.

Deep learning glaucoma detection can achieve high accuracy across diverse datasets with appropriate training strategies.

Oxidative Stress-Related Molecular Biomarker Candidates for Glaucoma.

Findings of this study encourage further validation studies of oxidative stress-related biomarkers in glaucoma.

T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.

These findings suggest that the immunity activated in glaucoma may not be counterbalanced by an efficient immune suppression.

Ophthalmology and Glaucoma Practice in the COVID-19 Era.

Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.

Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera.

Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma.

Although the rate of RNFL thinning worsened in a DH quadrant after DH, glaucoma treatment intensification may have a beneficial effect in reducing this rate of thinning.

Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.

A novel association with advanced POAG in the EN04 locus was identified putatively in persons of AD.

Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning.

The model's high diagnostic accuracy using OHTS photographs suggests that DL has the potential to standardize and automate POAG determination for clinical trials and management.

New Recommendations for the Treatment of Systemic Hypertension and their Potential Implications for Glaucoma Management.

Association of Glaucoma-Related, Optical Coherence Tomography-Measured Macular Damage With Vision-Related Quality of Life.

Characteristic patterns of glaucoma-related macular RGC+IPL loss appeared to be more important predictors of vision-related quality of life than thickness measures, with diffuse RGC+IPL loss as an indicator for diminished vision-related quality of life.

Macular Damage, as Determined by Structure-Function Staging, Is Associated With Worse Vision-related Quality of Life in Early Glaucoma.

Early glaucomatous macular damage, as detected by abnormal topographic regions on measures of structure and function, is associated with decreased VRQoL.

Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss.

The presence of central VF damage at baseline is significantly associated with more rapid global progression. Detection of central VF damage aids in stratification of high-risk patients who may need intensive surveillance and aggressive treatment.

Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.

In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness.

Characteristics and variations of in vivo Schlemm's canal and collector channel microstructures in enhanced-depth imaging optical coherence tomography.

High-quality images of the aqueous outflow pathway can be obtained with a clinical device, avoiding postacquisition processing.

Glaucoma Diagnostic Capability of Global and Regional Measurements of Isolated Ganglion Cell Layer and Inner Plexiform Layer.

Isolated macular GCL appears to be as good as GCC and GCIPL in glaucoma diagnosis, while IPL does not.

Impact of Smoking on Visual Field Progression in a Long-term Clinical Follow-up.

Heavy smokers are more likely to sustain VF loss in eyes with glaucoma.

Association of Macular Visual Field Measurements With Glaucoma Staging Systems.

These findings suggest that current glaucoma staging systems based on 24-2 (or 30-2) visual fields underestimate disease severity and the presence of macular damage.

Racial Differences in Rate of Change of Spectral-Domain Optical Coherence Tomography-Measured Minimum Rim Width and Retinal Nerve Fiber Layer Thickness.

Race is an important consideration when assessing structural change, particularly minimum rim width, in glaucoma suspect eyes. Differences in rate of structural change may help explain racial disparities in glaucoma susceptibility.

Measuring Rates of Visual Field Progression in Linear Versus Nonlinear Scales: Implications for Understanding the Relationship Between Baseline Damage and Target Rates of Glaucoma Progression.

There is a significant relationship between baseline visual field severity and rates of MD progression, although the direction of this association depends on the scale sensitivity is measured.

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss.

This study found that approximately 1 in 8 eyes with glaucoma receiving routine care showed fast progression based on global MD values (< -1.0 dB/year) and that nearly 1 in 3 eyes showed a < -0.5 dB/year decline centrally.

Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics Based on Thickness Maps from Macula OCT.

Deep learning models improved estimates of functional loss from SD OCT imaging. Accurate estimates can help clinicians to individualize VF testing to patients.

Automated Beta Zone Parapapillary Area Measurement to Differentiate Between Healthy and Glaucoma Eyes.

Larger βPPA area, as determined by automated OCT assessment, is significantly associated with a diagnosis of glaucoma, even after adjusting for age and AL, and may aid in differentiating healthy from glaucomatous eyes.

Microarchitecture of Schlemm Canal Before and After Selective Laser Trabeculoplasty in Enhanced Depth Imaging Optical Coherence Tomography.

SLT expands SC in POAG patients and even more so with greater IOP reduction after SLT.

Review of Hygiene and Disinfection Recommendations for Outpatient Glaucoma Care: A COVID Era Update.

This review focuses on best practices and recommendations for hygiene and disinfection to limit exposure and transmission of infection in outpatient glaucoma clinics during the current COVID-19 pandemic.

Diffuse Macular Damage in Mild to Moderate Glaucoma Is Associated With Decreased Visual Function Scores Under Low Luminance Conditions.

Mild diffuse glaucomatous macular damage, as detected by abnormal topographic regions on measures of structure and function, is associated with decreased LLQ scores.

A Longitudinal Analysis of Peripapillary Choroidal Thinning in Healthy and Glaucoma Subjects.

The rate of peripapillary choroidal thinning was not significantly different between healthy and glaucoma eyes during this relatively short follow-up period.

β-Zone Parapapillary Atrophy and Rates of Glaucomatous Visual Field Progression: African Descent and Glaucoma Evaluation Study.

Race had a significant effect on the association between baseline βPPA and rates of visual field progression in eyes with GON.

Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest.

Eye-specific ROIs identified using DL-AE analysis of OCT images show promise for improving assessment of glaucomatous progression.

Manhattan Vision Screening and Follow-up Study in Vulnerable Populations (NYC-SIGHT): Design and Methodology.

This study targets vulnerable populations where they live to ensure improved access to and utilization of eye care services in those who are least likely to seek eye care.

Macular Damage in Glaucoma is Associated With Deficits in Facial Recognition.

Even with good central visual acuity, patients with glaucomatous macular damage exhibit diminished facial recognition, which is partly mediated through diminished CS.

Association of Intraocular Pressure With Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma.

In this study, intraocular pressure variability was independently associated with structural change in patients with glaucoma, even after adjustment for mean intraocular pressure, supporting its potential value in clinical management.

Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements.

The proposed CNNmodel improved the estimation of 10-2 VF map based on circumpapillary SD-OCT RNFL thickness measurements.

Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES).

This study demonstrates that a deeper ALCSD, regardless of the ALCSD reference plane used, is associated with more severe glaucoma and higher IOP in the ADAGES cohort, particularly in individuals of AD.

Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices.

DSEK after GDD is a viable alternative to treat endothelial dysfunction, with the majority of patients achieving visual improvement.

The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

With its large sample size, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control participants from different regions in the United States, the ADAGES III genomics study will address gaps in…

Glaucoma Diagnostic Capability of Circumpapillary Retinal Nerve Fiber Layer Thickness in Circle Scans With Different Diameters.

Further investigations to find the spectral-domain OCT circle scan diameter with the best diagnostic capability and the least artifacts are warranted, especially focusing on larger-than-conventional circle scans.

Rationale and Development of an OCT-Based Method for Detection of Glaucomatous Optic Neuropathy.

A decision tree was devised for testing and implementation in clinical practice and research that can be used by reading centers, researchers, and clinicians.

Deep Learning Identifies High-Quality Fundus Photographs and Increases Accuracy in Automated Primary Open Angle Glaucoma Detection.

The DL quality model was able to accurately assess fundus photograph quality. Using automated quality assessment to filter out low-quality photographs increased the accuracy of a DL POAG detection model.

Association of Patterns of Glaucomatous Macular Damage With Contrast Sensitivity and Facial Recognition in Patients With Glaucoma.

In this cohort study, diffuse rather than focal glaucomatous macular damage was associated with diminished facial recognition and contrast sensitivity.

Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric Glaucoma Patients.

These findings suggest that patients with perimetric and preperimetric glaucoma have worse VRQOL than patients with healthy eyes.

Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.

Rates of VF progression were similar despite higher treated IOP in the Black race group.

Patient Concerns Regarding Suspended Ophthalmic Care Due to COVID-19.

We found a majority of our patients were concerned about limitations in access to ophthalmic care and were fearful of disease progression.

Detection of Progression With 10-2 Standard Automated Perimetry: Development and Validation of an Event-Based Algorithm.

A new event-based progression algorithm using the 10-2 VF can identify eyes experiencing more rapid MD progression and may be used as a tool to assess progressive macular functional changes in glaucoma.

Disc Hemorrhages Are Associated With the Presence and Progression of Glaucomatous Central Visual Field Defects.

DH was associated with the presence and progression of central VF defects. DH identification should prompt intensive central VF monitoring and surveillance with 10-2 fields to detect progression.

Association Between Rate of Ganglion Cell Complex Thinning and Rate of Central Visual Field Loss.

In this cohort study, rapid GCC thinning during an initial follow-up period was associated with faster rates of central visual field decline.

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor of Central Visual Field Progression in Glaucoma.

Lower CH was associated with a statistically significant, but relatively small, increased risk of central VF progression on the 10-2 test grid.

Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes.

The severity and prevalence of central VF loss varied among different glaucomatous optic disc phenotypes.

Baseline Age and Mean Deviation Affect the Rate of Glaucomatous Vision Loss.

Older age and worse MD at baseline are associated with more rapid VF progression in this large dataset.

Association of Rates of Ganglion Cell and Inner Plexiform Thinning With Development of Glaucoma in Eyes With Suspected Glaucoma.

This study found that faster rates of GCIPL and cpRNFL thinning were associated with higher risks of developing perimetric glaucoma.

A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design.

Our deep learning models were able to accurately estimate both macula GCIPL and ONH RNFL hemiretinal thickness.

Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage.

Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location.

An Examination of the Frequency of Paravascular Defects and Epiretinal Membranes in Eyes With Early Glaucoma Using En-face Slab OCT Images.

Eyes with early glaucoma have a higher frequency of PDs and ERMs than suspects or controls and exhibit PDs even in the absence of ERMs or high myopia.

The Effect of Therapeutic IOP-lowering Interventions on the 24-hour Ocular Dimensional Profile Recorded With a Sensing Contact Lens.

Incisional glaucoma surgery had a more pronounced effect on GAT and CLS parameters than laser and drugs.

Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): Baseline Results and Costs of a Cluster-Randomized Trial.

This innovative study in public housing developments targeted high-risk populations, provided access to eye-care, and improved early detection of ocular diseases in New York City.

An Evaluation of a New 24-2 Metric for Detecting Early Central Glaucomatous Damage.

Neither the PSD(C24-2) nor the PSD(10-2) metric is good measure of early CD. Instead we recommend a topographic approach based upon OCT probability maps and a 10-2 VF.

The Challenge of Managing Bilateral Acute Angle-closure Glaucoma in the Presence of Active SARS-CoV-2 Infection.

We report a rare case of bilateral acute angle-closure glaucoma associated with hyponatremia.

Reoperations for Complications Within 90 Days After Glaucoma Surgery.

Early postoperative complications requiring reoperations within the first 90 days after glaucoma surgery were low and comparable with previous studies. Common indications for reoperation within 90 days include wound leak and tube shunt-related issues.

Association between Rates of Retinal Nerve Fiber Layer Thinning and Previous Disc Hemorrhage in Glaucoma.

A history of DH is an independent risk factor for faster rates of RNFL thinning in non-DH quadrants and in DH quadrants; this risk is present even in eyes that exhibited DH several years earlier.

Frequency of Optical Coherence Tomography Testing to Detect Progression in Glaucoma.

With high specificity and less variability than perimetry, a 6-month testing interval provides a reasonable trade-off for following glaucoma patients using OCT.

A Model of Progression to Help Identify Macular Damage Due to Glaucoma.

Second, the patterns of progression predicted by the model suggest alternative end points for clinical trials. Finally, the model provides a heuristic for future research concerning the anatomic basis of glaucomatous damage.

Variability and Power to Detect Progression of Different Visual Field Patterns.

Time to detect central VF progression was reduced with 10-2 MD compared with 24-2 and C24-2 MD in glaucoma eyes in this large dataset, in part because 10-2 tests had lower variability.

The Relationship Between Intraocular Pressure and Rates of Central Versus Peripheral Visual Field Progression.

The effect of IOP parameters on VF progression was statistically similar between central and peripheral VF regions.

American Glaucoma Society-American Academy of Ophthalmology Position Statement on Nicotinamide Use for Glaucoma Neuroprotection.

Glaucoma and the Human Microbiome.

Bacterial lipopolysaccharides (LPS) activate toll-like receptors (TLR) and mediate the human immune response.

Progressive Visual Field Loss and Subsequent Quality of Life Outcomes in Glaucoma.

Baseline severity and initial rates of change of VF damage are associated with QOL outcomes over an extended follow-up.

Racial Differences in Detection of Glaucoma Using Retinal Nerve Fiber Layer Thickness and Bruch Membrane Opening Minimum Rim Width.

RNFLT and BMO-MRW had consistently lower diagnostic performance in AD individuals compared with ED individuals.

Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers.

After ≥25 years of smoking cessation, the risk of VF progression in former heavy smokers becomes similar to never smokers. Long-term smoking cessation may be associated with lower VF progression in glaucoma patients.

The 24-2 Visual Field Guided Progression Analysis Can Miss the Progression of Glaucomatous Damage of the Macula Seen Using OCT.

In eyes with early glaucoma (i.e., 24-2 MD, > -6 dB) in this study, the 24-2 GPA missed progression seen using OCT and exhibited a relatively high rate of false positives.

Long-Term Blood Pressure Variability and Visual Field Progression in Glaucoma.

In this cohort study, higher mean blood pressure and higher SD of blood pressure were associated with faster VF progression.

Drug-Induced Liver Injury During a Glaucoma Neuroprotection Clinical Trial.

This report is important to share with the medical community, as other participants in glaucoma nicotinamide trials globally may have similar adverse events and many patients are using nicotinamide as a health supplement without medical supervision.

Time to Glaucoma Progression Detection by Optical Coherence Tomography in Individuals of African and European Descents.

Time to progression detection was similar for both races when assuming identical RNFLT baseline/thinning rates, and shorter in AD eyes under real-world simulation when AD had faster RNFLT thinning.

Clinical Factors Associated With Long-Term OCT Variability in Glaucoma.

Relevant clinical factors affecting long-term RNFLT variability in glaucoma were identified.

Outcomes of the Second Aqueous Shunt Implant Versus Transscleral Cyclophotocoagulation Treatment Study: A Randomized Comparative Trial.

Short-term overall success rates were high with either SGDD or CPC. However, SGDD was associated with more clinic visits and an increased risk of additional glaucoma surgery.

Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma.

These findings suggest that faster and sectoral central location of ganglion cell complex thinning provides useful information in determining the risk of vision-related quality of life in glaucoma.

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study.

Glaucomatous remodeling of the lamina cribrosa differs between AD and ED patients with glaucoma.

Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage.

The rate of mGCIPL and cpRNFL thinning was faster in DH eyes than non-DH eyes.

Changes in Iridocorneal Angle and Anterior Chamber Structure in Eyes With Anatomically Narrow Angles: Laser Iridotomy Versus Pilocarpine.

LI is more effective than pilocarpine in widening the iridocorneal angle without significant shallowing the anterior chamber in eyes with ANA.

Visual Field Progression in the Ocular Hypertension Treatment Study.

Some participants in OHTS had rapid rates of VF loss in one or both eyes despite being followed in a clinical study.

Time to Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field in Glaucoma Individuals of African Descent.

Computer simulation showed a potentially shorter time to detect RNFLT progression than VF MD progression in eyes from individuals of AD.

Automated Identification of Clinically Relevant Regions in Glaucoma OCT Reports Using Expert Eye Tracking Data and Deep Learning.

Our approach has the potential to assist ophthalmologists in diagnosing glaucoma by predicting the most medically salient regions on OCT reports.

The ICD-10 Glaucoma Severity Score Underestimates the Extent of Glaucomatous Optic Nerve Damage.

The ICD-10 system relies solely on damage seen on the 24-2 and as provides a 24-2 functional score rather than a "glaucoma" severity score.

Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Pars Plana Versus Anterior Chamber Glaucoma Drainage Devices.

There was no reduction in donor dislocation or SGF in eyes with PP compared with AC GDD, despite the decreased proximity of the shunt from the endothelial graft.

Is it Time to Revisit Glaucoma Suspect Nomenclature?

Association Between Longitudinal 10-2 Central Visual Field Change and the Risk of Visual Acuity Loss in Mild-to-Moderate Glaucoma.

Faster 10-2 VF MD and hemifield MS worsening are associated with the development of VA loss. Monitoring the longitudinal central 10-degree VF change may suggest that there is impending VA impairment in glaucoma.

Progression of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.

Although relying solely on metrics is not recommended for clinical purposes, in situations requiring very high specificity and precision, combinations of OCT-OCT metrics can be used.

Did the OCT Show Progression Since the Last Visit?

Instead of relying on the GPA analysis or summary statistics, one needs to evaluate RNFL and ganglion cell+inner plexiform layer probability maps and circumpapillary OCT B-scan images.

Association between Rates of Retinal Nerve Fiber Layer Thinning after Intraocular Pressure-Lowering Procedures and Disc Hemorrhage.

POAG or glaucoma suspect eyes with a history of DH should be carefully followed after IOP-lowering procedures.

Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma.

Central VF change had a greater impact on VRQOL compared to global VF change.

Patient Navigators Improve In-Office Eye Exam Adherence After Community Eye Screenings in a Randomized Clinical Trial: NYC-SIGHT Study.

Patient navigators improved adherence to in-office eye exams following community-based eye health screenings and referral to ophthalmology among an underserved population.

Optic Disc Size and Circumpapillary Retinal Nerve Fiber Layer Thinning in Glaucoma.

Larger optic disc size is associated with faster cpRNFL thinning in glaucoma, independent of race.

Risk of Falls, Fear of Falling, and Rates of Visual Field Progression in Glaucoma in the African Descent and Glaucoma Evaluation Study.

A faster rate of MD progression is associated with a greater fear of falling and history of falls among AD and ED treated glaucoma patients.

Association of Long-Term Intraocular Pressure Variability and Rate of Ganglion Complex Thinning in Patients With Glaucoma.

IOP variability showed an independent association with macular change in patients with glaucoma regardless of severity at baseline, even after adjustment for mean IOP, supporting its potential value as a therapeutic target for clinical decision-making.

Racial Differences in Diagnostic Accuracy of Retinal Nerve Fiber Layer Thickness in Primary Open-Angle Glaucoma.

OCT-RNFLT has lower diagnostic accuracy in eyes of AD compared to those of ED.

Glaucoma Detection Using Optical Coherence Tomography: Reviewing the Pitfalls of Comparison to Normative Data.

This review describes various artifacts that originate from using a normative database to compare the individual's scans.

Detecting Established Glaucoma Using OCT Alone: Utilizing an OCT Reading Center in a Real-World Clinical Setting.

An OCT-based reading center is able to identify eyes with established glaucoma using OCT alone with high sensitivity and specificity.

Identifying Rapid Glaucoma Progression Using Hemifield Rates of Progression.

Hemifield ROPs are more sensitive to focal progression (or faster progression) than global rates and can aid in tailoring management and treatment decisions.

What is the Optimal Frequency of Visual Field Testing to Detect Rapid Progression Among Hypertensive Eyes?

Given the importance of not missing the conversion to glaucoma, the frequency of testing used in OHTS (6 mo) was optimal for the detection of progression in high-risk patients.

Remote Contrast Sensitivity Testing Seems to Correlate With the Degree of Glaucomatous Macular Damage.

This study suggests that a free, rapid home CS test correlates with glaucomatous macular damage as measured by 10-2 VF.

Risk Calculation in the Medication Arm of the Ocular Hypertension Treatment Study.

The OHTS calculator can be applied to treated patients with OHTN, and repeat risk calculation after initiating IOP reduction may provide useful information that can aid in disease management.

Combined Use of Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma-Reply.

Rates of Retinal Nerve Fiber Layer Thinning in Distinct Glaucomatous Optic Disc Phenotypes in Early Glaucoma.

Rates of cpRNFL thinning were different among the 4 glaucomatous optic disc phenotypes.

Association of Macular Optical Coherence Tomography Measures and Deficits in Facial Recognition in Patients With Glaucoma.

This study investigates the association between facial recognition and macular structural damage, as measured by spectral-domain ocular coherence tomography retinal ganglion cell and inner plexiform layer.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed.

Performance of General-Purpose Vision Language Models and Ophthalmology Foundation Models in Glaucoma Detection and Function Prediction.

Fine-tuned VLMs demonstrated high performance in glaucoma detection and VF MD prediction, matching or exceeding specialized foundation models and traditional convolutional neural network (CNN)-based methods.

Costs Associated With the Use of Disposable Gonioscopy Lenses and Tonometry Tips.

A widespread transition from reusable to disposable tonometry and gonioscopy equipment was associated with an additional cost of $965,161 over a 10-year period at a single institution.

Impact of Physical Activity Levels on Visual Field Progression in Individuals With Glaucoma.

Higher PA amounts are an independent predictor of a slower rate of VF MD loss. Further research is needed to explore whether increased PA protects against glaucoma progression.

Glaucoma Screening and Referral Risk Factors in a High-Risk Population: Follow-Up Study of the Manhattan Vision Screening Study.

Our findings support public health approaches that focus on community-based eye health screenings in high-risk populations and prioritize underserved communities.

Direct Costs of Second Aqueous Shunt Implant Versus Transscleral Cyclophotocoagulation (The Assists Trial).

The total direct cost in the SGDD group was more than double that in the CPC group, driven largely by the cost of the study procedure.

The Role of Intraocular Pressure and Systemic Hypertension in the Progression of Glaucomatous Damage to the Macula.

Macular structural and functional parameters are more sensitive to IOP in terms of glaucomatous progression when compared with more conventional parameters.

Characterization of Temporal Delay and Modeling of Intraocular Pressure and Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES).

ROP changes trail IOP changes by 4-7 months, an important consideration when obtaining additional VFs to capture or rule-out progression.

Proportion of Fast Progressors in the Central versus Global Visual Field Across Varying Glaucoma Severity Groups.

Selective analysis of the MTDdetected a greater proportion of eyes that exhibited fast progression across all disease severity groups compared to measurements from the entire VF, underscoring the importance of close monitoring for progressive central…

Nicotinamide and Pyruvate in Open-Angle Glaucoma: A Randomized Controlled Trial on Neuroprotection-Design and Methodology.

This novel trial design may deliver valuable data on the neuroprotective potential of nicotinamide and pyruvate supplementation in glaucoma and improve our understanding of optimal study design for longitudinal randomized clinical trials focused on glaucoma neuroprotection.

Comparison of Methods for Visual Field Progression in Eyes With Central Visual Field Defects.

Agreement among methods for central VF progression monitoring is low to moderate. Concordance between 24-2 and 10-2 VF methods is variable, with 10-2 detecting a higher proportion of central progression.

Initial circumpapillary retinal nerve fibre layer rates of change predict glaucomatous progression.

The rate of initial cpRNFL change observed within half the monitoring period may effectively predict the subsequent structural progression and can be used by clinicians to predict the course of glaucoma when monitoring patients.

A Morphologic Model of Glaucomatous Damage to the Macular Ganglion Cell Layer in Myopic Eyes.

The proposed model of glaucomatous damage patterns in macula GCL is applicable to myopic eyes, even with coexisting macular pathology. In cases deviating from the model, clinicians are advised to seek causes besides glaucoma.

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Increasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year.

Targeted Screening for Glaucoma.

Implementation and Consensus.

The provided abstract contains no information. Therefore, a précis summarizing key findings and clinical relevance cannot be generated.

Understanding Patterns of Preserved Retinal Ganglion Cell Layer in Advanced Glaucoma as Seen With Optical Coherence Tomography.

All eyes with advanced glaucoma had damage to the critically important central, donut-shaped GCL region.

Association of Psychosocial Factors with Activation Among Patients with Glaucoma.

We identified modifiable behavioral factors that could increase patients' self-perceived ability and confidence to manage their own eye care.

Acute Onset Optic Disc Hemorrhage Following Pharmacologic Mydriasis.

Cycloplegia may cause subtle shifts in vitreous and lamina cribrosa position that may result in the formation of optic DHs in susceptible glaucomatous eyes.

In Reply: Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices.

In Reply: Calcium Channel Blockers and Risk of Primary Open-angle Glaucoma.

Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.

Although some predictors were identified, long-term RNFLT variability appeared small for both AD and ED eyes.

Visual field progression patterns in the ocular hypertension treatment study correspond to vulnerability regions of the disc.

Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss.

Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT): optometric exam improves access and utilization of eye care services.

This community-based screening initiative demonstrated the effectiveness of optometric exams in detecting vision-affecting conditions and identified factors associated with having a recent dilated eye exam.

Improving glaucoma staging in clinical practice by combining the ICD-10 glaucoma severity classification system and optical coherence tomography.

Combining OCT and VF data provides better staging of glaucoma severity than VF data alone.

Reply.

Descemet Stripping Endothelial Keratoplasty in Eyes With Previous Glaucoma Surgery.

There is a significant incidence of graft dislocation and graft failure after DSAEK in eyes with previous glaucoma surgery.

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.

Higher levels of IOP during follow-up were associated with faster rates of RNFL loss over time measured by SD OCT.

Effect of Pilocarpine Hydrochloride on the Schlemm Canal in Healthy Eyes and Eyes With Open-Angle Glaucoma.

These data suggest that pilocarpine expands the Schlemm canal in eyes with and without glaucoma.

Structural Change Can Be Detected in Advanced-Glaucoma Eyes.

Ganglion cell-inner plexiform layer and 3D volume BKDS show promise for identifying change in severely advanced glaucoma.

African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy.

Subjects of ED are at higher risk for developing DH compared with AD subjects, whereas AD subjects have greater prevalence of βPPA.

Technology and the Glaucoma Suspect.

Compared to VF and disc photography, SD-OCT, when used alone, had better internal agreement as well as better agreement with the consensus of clinicians using all available data.

Unsupervised Gaussian Mixture-Model With Expectation Maximization for Detecting Glaucomatous Progression in Standard Automated Perimetry Visual Fields.

GEM-POP was significantly more sensitive to PGON than PoPLR and linear regression of MD and VFI in our sample, while providing localized progression information.

Self-reported Function, Health Resource Use, and Total Health Care Costs Among Medicare Beneficiaries With Glaucoma.

Glaucoma is associated with greater use of inpatient and home health aide services and with higher annual total and nonoutpatient medical costs.

Efficacy of the Amsler Grid Test in Evaluating Glaucomatous Central Visual Field Defects.

The Amsler grid can be used to screen for moderate to severe central vision loss from glaucoma.

Visual Field Change and 24-Hour IOP-Related Profile with a Contact Lens Sensor in Treated Glaucoma Patients.

Intraocular pressure-related parameters obtained with 24-hour recording with a CLS were associated with the rate of visual field progression in treated glaucomatous eyes.

Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes.

Compared with healthy eyes, the mean rate of global rim area loss was 3.7 times faster and the mean rate of global percentage rim area loss was 5.4 times faster in progressing glaucoma eyes.

Variation in Prescription Drug Coverage Enrollment Among Vulnerable Beneficiaries With Glaucoma Before and After the Implementation of Medicare Part D.

Medicare Part D enrolled most beneficiaries with glaucoma who previously lacked prescription drug coverage.

Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes.

The Spectralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good agreement for detection of eyes with early glaucoma damage.

Cost-Related Medication Nonadherence and Cost-Saving Behaviors Among Patients With Glaucoma Before and After the Implementation of Medicare Part D.

After the implementation of Part D, there was a decrease in the rate that beneficiaries with glaucoma reported engaging in cost-saving measures.

Author reply: To PMID 24869467.

The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects.

In this cohort of glaucoma suspects with similar access to treatment, multivariate analysis revealed that at higher mean IOP during follow-up, individuals of African descent were more likely to develop VF damage than individuals of…

Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure.

The BGA correlates with variation in ocular features that significantly differ across racial groups and that have been associated with the development of glaucoma.

Lamina cribrosa depth in different stages of glaucoma.

In treated glaucoma, posterior LC displacement occurs mostly in the preperimetric and mild-to-moderate glaucoma stages. This warrants further investigation of LC depth as a parameter to monitor glaucoma progression in the early stages.

Author reply: To PMID 24869467.