Medeiros Felipe A

Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma.

Decreased vessel density was significantly associated with the severity of visual field damage independent of the structural loss.

Peripapillary and Macular Vessel Density in Patients with Glaucoma and Single-Hemifield Visual Field Defect.

Reduced peripapillary and macular vessel density was detectable in the perimetrically intact hemiretinae of glaucoma eyes with a single-hemifield defect.

Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma.

Systemic and ocular factors including focal LC defects more advanced glaucoma, reduced RNFL vessel density, thinner choroidal thickness, and lower diastolic blood pressure were factors associated with the parapapillary deep-layer microvasculature dropout in glaucomatous eyes.

From Machine to Machine: An OCT-Trained Deep Learning Algorithm for Objective Quantification of Glaucomatous Damage in Fundus Photographs.

We introduced a novel DL approach to assess fundus photographs and provide quantitative information about the amount of neural damage that can be used to diagnose and stage glaucoma.

Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma.

In advanced glaucoma, more GC-IPL tissue remains above the measurement floor compared with other measurements, suggesting GC-IPL thickness is the better candidate for detecting progression. Progression in SDOCT measurements is observable in advanced disease.

Detecting Structural Progression in Glaucoma with Optical Coherence Tomography.

Identification of such patients offers the possibility of commencing or escalating treatment at an earlier stage. This review appraises recent developments in the use of OCT for assessing glaucoma progression.

24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma.

Central visual field damage seen on the 10-2 test is often missed with the 24-2 strategy in all groups. This finding has implications for the diagnosis of glaucoma and classification of severity.

Deep Learning and Glaucoma Specialists: The Relative Importance of Optic Disc Features to Predict Glaucoma Referral in Fundus Photographs.

A DL algorithm trained on fundus images alone can detect referable GON with higher sensitivity than and comparable specificity to eye care providers.

A Review of Deep Learning for Screening, Diagnosis, and Detection of Glaucoma Progression.

Deep learning algorithms have the potential to significantly improve diagnostic capabilities in glaucoma, but their application in clinical practice requires careful validation, with consideration of the target population, the reference standards used to build the…

Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects.

In eyes with similar severity of glaucoma, OCT-A-measured vessel density was significantly lower in POAG eyes with focal LC defects than in eyes without an LC defect.

Comparing the Rates of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Loss in Healthy Eyes and in Glaucoma Eyes.

In this cohort, the rate of circumpapillary RNFL thickness change was faster than macular GCIPL change for glaucoma eyes.

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

Both dose strengths of bimatoprost implant met the primary end point of noninferiority to timolol through week 12.

Assessment of a Segmentation-Free Deep Learning Algorithm for Diagnosing Glaucoma From Optical Coherence Tomography Scans.

A segmentation-free DL algorithm performed better than conventional RNFL thickness parameters for diagnosing glaucomatous damage on OCT scans, especially in early disease.

Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression.

A computational approach can identify structural features that improve glaucoma detection and progression prediction.

Human Versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs.

An M2M DL algorithm performed as well as, if not better than, human graders at detecting eyes with repeatable glaucomatous visual field loss.

A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss From Optic Disc Photographs.

A DL network can be trained to quantify the amount of neuroretinal damage on optic disc photographs using SDOCT BMO-MRW as a reference.

Frequency of Testing to Detect Visual Field Progression Derived Using a Longitudinal Cohort of Glaucoma Patients.

This study provides information on the time required to detect progression using MD trend analysis in glaucoma eyes when different testing frequencies are used.

Detecting Glaucoma With a Portable Brain-Computer Interface for Objective Assessment of Visual Function Loss.

The BCI device may be useful for assessing the electrical brain responses associated with visual field stimulation.

Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning.

This study highlights how current definitions for detecting RNFL thinning have an unacceptably poor level of specificity, and that more stringent definitions are required to avoid misleading interpretations of progression on OCT imaging in clinical practice.

Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning.

A deep learning model was able to obtain objective and quantitative estimates of RNFL thickness that correlated well with SD OCT measurements and potentially could be used to monitor for glaucomatous changes over time.

Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.

Although most patients under routine care had slow rates of progression, a substantial proportion had rates that could potentially result in major losses if sustained over time.

Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure.

Approximately one-quarter of eyes with well-controlled IOP may show visual field progression over time. Thin cornea and low CH are main risk factors.

Endpoints for clinical trials in ophthalmology.

In this article we summarize candidates for clinical endpoints in ophthalmology with a focus on retinal disease and glaucoma.

Detection of Glaucoma Progression in Individuals of African Descent Compared With Those of European Descent.

Patients of African descent with glaucoma showed increased visual field variability compared with those of European descent, resulting in delayed detection of progression that may contribute to explain higher rates of glaucoma-related visual impairment in…

Association Between Neurocognitive Decline and Visual Field Variability in Glaucoma.

Cognitive decline was associated with increased visual field variability during follow-up.

Artificial Intelligence Mapping of Structure to Function in Glaucoma.

A CNN was capable of predicting SAP sensitivity thresholds from SDOCT RNFL thickness measurements and generate an SF map from simulated defects.

The Effect of Age on Increasing Susceptibility to Retinal Nerve Fiber Layer Loss in Glaucoma.

Age is a significant modifier of the relationship between IOP and glaucomatous loss in RNFL thickness over time.

The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes.

The strength of the association of VD with cpRNFL and mGCC thicknesses varies by retinal layer.

Performance of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma.

10-2 and 24-2 tests identified a similar number of eyes with, suspected of having, or at risk of having glaucoma as having central visual field abnormalities using PSD values.

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Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression.

Pointwise event-based and global trend-based methods had similar performances to detect glaucoma progression when rigorously matched for specificity.

Blood Pressure and Glaucomatous Progression in a Large Clinical Population.

When adjusted for IOP, lower MAP and DAP during follow-up were significantly associated with faster rates of RNFL loss, suggesting that levels of systemic BP may be a significant factor in glaucoma progression.

Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma.

Rapid RNFL thinning during an initial follow-up period was predictive of concurrent and subsequent rates of visual field decline over an extended period.

Predicting Glaucoma Development With Longitudinal Deep Learning Predictions From Fundus Photographs.

Longitudinal changes in a deep learning algorithm's predictions of RNFL thickness measurements based on fundus photographs can be used to predict risk of glaucoma conversion in eyes suspected of having the disease.

Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.

A novel association with advanced POAG in the EN04 locus was identified putatively in persons of AD.

Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer Loss in a Large Clinical Population.

Intraocular pressure was significantly associated with rates of progressive RNFL loss in a large clinical population.

Biomarkers and Surrogate Endpoints: Lessons Learned From Glaucoma.

However, imaging biomarkers could potentially be used as part of composite endpoints in glaucoma trials, overcoming weaknesses of the use of structural or functional endpoints in isolation.

The Frequency of Visual Field Testing in a US Nationwide Cohort of Individuals with Open-Angle Glaucoma.

More than 75% of enrollees with OAG received < 1 visual field test per year and, thus, did not receive guideline-adherent glaucoma monitoring.

Improving the Feasibility of Glaucoma Clinical Trials Using Trend-Based Visual Field Progression Endpoints.

The feasibility of future glaucoma clinical trials can be substantially improved by evaluating differences in the rate of visual field change between groups.

Rates of Glaucoma Progression Derived from Linear Mixed Models Using Varied Random Effect Distributions.

Linear mixed models using the LG distribution outperformed conventional approaches for estimating rates of SAP MD loss in a population with glaucoma.

Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss.

The presence of central VF damage at baseline is significantly associated with more rapid global progression. Detection of central VF damage aids in stratification of high-risk patients who may need intensive surveillance and aggressive treatment.

Comparing 10-2 and 24-2 Visual Fields for Detecting Progressive Central Visual Loss in Glaucoma Eyes with Early Central Abnormalities.

Trend-based analyses using 10-2 MD resulted in a mild reduction (7-9%) in the time to detect central visual field progression compared to C24-2 MD in glaucoma eyes with early central visual field abnormalities.

Deep Learning-Assisted Detection of Glaucoma Progression in Spectral-Domain OCT.

A DL model was able to assess the probability of glaucomatous structural progression from SD-OCT RNFL thickness measurements.

Development of a Visual Field Simulation Model of Longitudinal Point-Wise Sensitivity Changes From a Clinical Glaucoma Cohort.

A new simulation model accounting for correlated measurement errors between visual field locations performed better than a previous model in estimating visual field variability in glaucoma.

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss.

This study found that approximately 1 in 8 eyes with glaucoma receiving routine care showed fast progression based on global MD values (< -1.0 dB/year) and that nearly 1 in 3 eyes showed a < -0.5 dB/year decline centrally.

Automated Beta Zone Parapapillary Area Measurement to Differentiate Between Healthy and Glaucoma Eyes.

Larger βPPA area, as determined by automated OCT assessment, is significantly associated with a diagnosis of glaucoma, even after adjusting for age and AL, and may aid in differentiating healthy from glaucomatous eyes.

A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma.

Our findings suggest that RNFLT parameters may be better able to identify pre-perimetric glaucomatous damage in glaucoma suspects than BMO-MRW.

Visual Crowding in Glaucoma.

In glaucoma patients, a pronounced visual crowding effect is observed, even in the presence of mild visual field loss on standard perimetry.

Association between Rates of Visual Field Progression and Intraocular Pressure Measurements Obtained by Different Tonometers.

Mean ORA IOPwas more predictive of rates of visual field loss than mean IOP obtained by GAT or RBT.

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma.

Baseline lower CH measurements were significantly associated with increased risk of developing glaucomatous visual field defects over time.

Special Commentary: Using Clinical Decision Support Systems to Bring Predictive Models to the Glaucoma Clinic.

Advances in the field of predictive modeling using artificial intelligence and machine learning have the potential to improve clinical care and outcomes, but only if the results of these models are presented appropriately to clinicians at the time they make decisions for individual patients.

Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.

Long-term variability was higher than short-term variability on SD-OCT and SAP.

A Longitudinal Analysis of Peripapillary Choroidal Thinning in Healthy and Glaucoma Subjects.

The rate of peripapillary choroidal thinning was not significantly different between healthy and glaucoma eyes during this relatively short follow-up period.

β-Zone Parapapillary Atrophy and Rates of Glaucomatous Visual Field Progression: African Descent and Glaucoma Evaluation Study.

Race had a significant effect on the association between baseline βPPA and rates of visual field progression in eyes with GON.

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression.

Rates of SAP MD change for eyes with glaucoma calculated over the initial 2 years of follow-up were strongly predictive of events of progression over subsequent follow-up.

Wayfinding and Glaucoma: A Virtual Reality Experiment.

Glaucoma patients performed significantly worse on allocentric-based wayfinding tasks conducted in a VR environment, suggesting visual field loss may affect the construction of spatial cognitive maps relevant to successful wayfinding.

Predicting Vision-Related Disability in Glaucoma.

A new methodology for classification and analysis of change in patient-reported quality-of-life outcomes allowed construction of models for predicting vision-related disability in glaucoma.

Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma.

The similarity in performance of the 10-2 and C24-2 test suggests that the increased sampling density of the former does not significantly improve the detection of central visual field abnormalities, even when based on expert assessment.

Performance of the Rule of 5 for Detecting Glaucoma Progression between Visits with OCT.

Loss of 5 μm or more in average RNFL thickness between consecutive SD OCT tests is not specific for glaucoma progression.

A Case for the Use of Artificial Intelligence in Glaucoma Assessment.

Artificial intelligence for glaucoma diagnosis would have high utility globally, because access to care is limited in many parts of the world and half of all people with glaucoma are unaware of their illness.

Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES).

This study demonstrates that a deeper ALCSD, regardless of the ALCSD reference plane used, is associated with more severe glaucoma and higher IOP in the ADAGES cohort, particularly in individuals of AD.

The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

With its large sample size, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control participants from different regions in the United States, the ADAGES III genomics study will address gaps in…

Socioeconomic Disparities in Glaucoma Severity at Initial Diagnosis: A Nationwide Electronic Health Record Cohort Analysis.

Worse OAG at presentation was associated with older age, male sex, Black race, Hispanic ethnicity, non-commercial insurance or uninsured status, secondary OAGs, and greater socioeconomic vulnerability in this nationwide cohort.

What Is the Amount of Visual Field Loss Associated With Disability in Glaucoma?

Application of an LCA model allowed categorization of patient-reported outcomes and quantification of visual field levels associated with disability in glaucoma.

Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.

Using a large real-world clinical database, we identified risk factors associated with presentation with blindness among glaucoma patients.

Single Administration of Bimatoprost Implant: Effects on 24-Hour Intraocular Pressure and 1-Year Outcomes.

A single intracameral administration of the bimatoprost implant lowered IOP in the habitual position consistently throughout the day and night at week 8.

Visual Field Outcomes in the Tube Versus Trabeculectomy Study.

Slow rates of VF loss were observed after randomized surgical treatment in the TVT Study, but no significant difference in the rate of VF loss was seen after tube shunt implantation and trabeculectomy with MMC.

Macular Pigment and Visual Function in Patients With Glaucoma: The San Diego Macular Pigment Study.

These results challenge previous studies that reported that glaucoma is associated with low MP.

Estimated Utility of the Short-term Assessment of Glaucoma Progression Model in Clinical Practice.

In this cohort study, results from the STAGE model with reduction of the rate of progression as the end point, frequent testing, and a moderate effect size, suggest that clinical trials to test efficacy of…

Comparison of 10-2 and 24-2 Perimetry to Diagnose Glaucoma Using OCT as an Independent Reference Standard.

The 24-2 SAP test had better diagnostic accuracy compared with that of the 10-2 test for detecting equivalent levels of glaucomatous damage, as measured by quantitative assessment of retinal nerve fiber layer and macula by OCT.

Comparing the Rule of 5 to Trend-based Analysis for Detecting Glaucoma Progression on OCT.

Trend-based analysis was superior to the simple rule of 5 for identifying progression in glaucoma eyes and should be preferred as a method for longitudinal assessment of global SD-OCT RNFL change over time.

Glaucoma and Driving Risk under Simulated Fog Conditions.

Glaucoma patients have a steeper increase in driving risk under fog conditions when compared to healthy subjects, especially when the severity of visual field damage falls below -9 dB of MD in the better eye.

Progression or Aging? A Deep Learning Approach for Distinguishing Glaucoma Progression From Age-Related Changes in OCT Scans.

A DL model was able to identify longitudinal glaucomatous structural changes in OCT B-scans using a surrogate reference standard for progression.

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Clustered testing in the Fast-PACE Study detected fast-progressing glaucoma eyes over 6 months.

Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.

The mean rate of SAP MD change in the fastest progressing eye was -1.06 dB/year (95% confidence interval [CI], -1.28 to -0.85 dB/year) for fast progressors compared with -0.10 dB/year (95% CI, -0.16 to -0.04 dB/year) for slow progressors (P < 0.001).

Association Between Greater Social Vulnerability and Delayed Glaucoma Surgery.

Residence in areas with higher SVI or ADI scores was associated with delayed glaucoma surgery after controlling for demographic and ocular parameters.

Impact of Social Vulnerability Index on the Development of Severe Visual Impairment or Blindness From Glaucoma.

Risk factors for developing glaucoma-related severe visual impairment or blindness included older age, elevated IOP during follow-up, moderate or severe disease at baseline, and residence in areas associated with greater social vulnerability.

The Definition of Glaucomatous Optic Neuropathy in Artificial Intelligence Research and Clinical Applications.

The development and validation of new AI-based diagnostic tests should be based on rigorous methodology with clear determination of how the reference standards for glaucomatous damage are constructed and the settings where the tests are going to be applied.

Effect of Diabetes Control on Rates of Structural and Functional Loss in Patients with Glaucoma.

We did not find a significant association between diabetes control, as measured by levels of HbA1c, and rates of visual field or RNFL loss over time in individuals with glaucoma or suspected glaucoma.

The Relationship Between Asymmetries of Corneal Properties and Rates of Visual Field Progression in Glaucoma Patients.

CH asymmetry between eyes was associated with asymmetry on rates of visual field change, providing further support for the role of CH as a risk factor for glaucoma progression.

Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis.

Although the cube scan-based BMO-MRW was significantly smaller than the radial scan-based BMO-MRW, we found no significant difference between the two scan patterns for detecting glaucoma, identifying BMO location and measuring the rate of BMO-MRW change.

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study.

Glaucomatous remodeling of the lamina cribrosa differs between AD and ED patients with glaucoma.

Decade-Long Profile of Imaging Biomarker Use in Ophthalmic Clinical Trials.

Imaging biomarkers are increasingly used in published CTs in ophthalmology.

Improved Prediction of Perimetric Loss in Glaucomatous Eyes Using Latent Class Mixed Modeling.

Latent class mixed model successfully identified distinct classes of progressors within a large glaucoma population that seemed to reflect subgroups observed in clinical practice.

Corneal Hysteresis and Rates of Neuroretinal Rim Change in Glaucoma.

Lower CH measurements were associated with faster loss of the neuroretinal rim in glaucoma, as measured by MRW.

Optical Coherence Tomography Versus Optic Disc Photo Assessment in Glaucoma Screening.

Both OCT and optic disc photography present valuable but distinct capabilities for glaucoma screening. An approach integrating AI technology might be key in optimizing these methods for effective, large-scale screening programs.

24-2 SITA Standard versus 24-2 SITA Faster in Perimetry-Naive Normal Subjects.

The SS and SFR were associated with similar specificities in perimetry-naive individuals.

Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.

No statistically significant difference in mean rates of visual field change was observed between trabeculectomy and tube shunt surgery in the PTVT Study.

Intraocular Pressure and Rates of Macular Thinning in Glaucoma.

Higher IOP was significantly associated with faster rates of GCL and GCIPL loss over time measured by SD-OCT, even during relatively short follow-up times.

Predicting Retinal Nerve Fiber Layer Thickness From Ocular Hypertension Treatment Study Optic Disc Photographs.

In this diagnostic study, baseline M2M-predicted RNFL thickness and longitudinal rate of change in predicted RNFL were putative risk factors for the development of glaucoma in patients with ocular hypertension.

Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma.

Faster VF progression in patients with glaucoma was associated with worsening performance on a divided attention task during driving simulation.

Association Between Serum Vitamin D Level and Rates of Structural and Functional Glaucomatous Progression.

We did not find a significant association between vitamin D level and rates of visual field or RNFL loss over time in individuals with glaucoma and glaucoma suspect patients.

Severe Glaucoma Associated With Changes in Gait Over Time.

Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management.

In this cohort study, while clinicians seem to generally use IOP as a continuous risk factor in their treatment patterns, with higher rates of glaucoma therapy at increasing IOP levels, these findings suggest that the…

Effect of Blood Pressure on Rates of Progression in Focal Ischemic vs. Generalized Cup Enlargement Glaucoma Phenotypes.

Lower systemic BP levels were associated with faster RNFL thinning in the FI optic disc phenotype but not in the GE phenotype.

Reply to Comment on "Artificial Intelligence-Guided Endpoint Selection for Neuroprotection Trials in Glaucoma".

Patient Attitudes toward Distress Screening and Referral in Glaucoma Care.

A mixed-methods study of 300 glaucoma patients found strong support for screening and referral for psychological distress.

RNFL Thickness in a Population-Based Cohort: The Canadian Longitudinal Study on Aging M2M (Machine-to-Machine) Study.

The M2M model provided robust estimates of RNFL thickness from fundus photographs in a large population-based cohort.

Retinal Ganglion Cell Loss and Patterns of Neuroretinal Rim Thinning at the Onset of Visual Field Defects in Glaucoma.

Diffuse rim thinning at the earliest stage of functional loss is associated with substantially greater RGC loss than localized thinning. These findings support incorporating structural features into early glaucoma assessment.

Time to Identify Glaucoma Progression Given Typical Visual Field Testing Frequencies in a US Nationwide Insured Population.

These results suggest that either visual field testing needs to be done more frequently or other methods of identification of progressive glaucoma vision loss need to be developed.

Inefficacy of Longitudinal Cup-to-Disc Ratio Measurements in Identifying Glaucoma Progression.

Longitudinal CDR data performs similar to random selection in identifying glaucoma progression on both structural and functional testing.

Intraocular Pressure Measurements With the Tono-Vera: A New Handheld Rebound Tonometer.

There was a strong correlation and agreement in IOP measurements between calibrated Tono-Vera IOP and ORA IOPg.

Erratum to "Socioeconomic Disparities in Glaucoma Severity at Initial Diagnosis: A Nationwide Electronic Health Record Cohort Analysis," American Journal of Ophthalmology, 263C, pages 50-60, 2024.

Hazard Detection During Simulated Driving in Glaucoma Patients.

RTs in response to hazardous driving situations were slower for glaucoma patients compared with controls.

Association of an Objective Structural and Functional Reference Standard for Glaucoma with Quality of Life Outcomes.

A glaucoma diagnosis, based on an objective reference standard for GON, was significantly associated with worse Rasch-adjusted scores of QoL.

Acute Angle Closure Glaucoma in Von Hippel-Lindau Syndrome.

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Deep Learning-Predicted RNFL Loss and Incident Glaucoma in the Canadian Longitudinal Study on Aging.

Deep learning-predicted retinal nerve fiber layer loss from fundus photos correlates with meaningful structural change and predicts incident glaucoma. This offers a valuable tool for glaucoma risk stratification, particularly where OCT is unavailable.

Topographic Agreement of Retinal Nerve Fiber and Ganglion Cell Loss Improves Incipient Glaucoma Detection.

Combining corresponding retinal nerve fiber and ganglion cell layer parameters, factoring in their correlation, significantly improves detection of incipient glaucoma, offering clinicians a powerful diagnostic tool.

Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma.

In a large clinical population with glaucoma, habits of tobacco and alcohol consumption showed no significant effect on the rates of RNFL change. Higher BMI was significantly associated with slower rates of RNFL loss.

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.

Higher levels of IOP during follow-up were associated with faster rates of RNFL loss over time measured by SD OCT.

Comparison of Latanoprostene Bunod 0.024% and Timolol Maleate 0.5% in Open-Angle Glaucoma or Ocular Hypertension: The LUNAR Study.

LBN 0.024% QD in the evening was noninferior to timolol 0.5% BID over 3 months of treatment, with significantly greater IOP lowering in subjects with OAG or OHT at all but the earliest time point evaluated, and…

Association of Fast Visual Field Loss With Risk of Falling in Patients With Glaucoma.

The rate of visual field loss was associated with a self-reported history of falls in the past year even after taking into account the magnitude of visual field defect.

The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma.

The ability to detect glaucoma progression by SAP versus SD-OCT is significantly influenced by the stage of disease.

African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy.

Subjects of ED are at higher risk for developing DH compared with AD subjects, whereas AD subjects have greater prevalence of βPPA.

Structural Change Can Be Detected in Advanced-Glaucoma Eyes.

Ganglion cell-inner plexiform layer and 3D volume BKDS show promise for identifying change in severely advanced glaucoma.

Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes.

Structure versus Function in Glaucoma: The Debate That Doesn't Need to Be.

Corneal Hysteresis and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma.

Lower CH was significantly associated with faster rates of RNFL loss over time.

Unsupervised Gaussian Mixture-Model With Expectation Maximization for Detecting Glaucomatous Progression in Standard Automated Perimetry Visual Fields.

GEM-POP was significantly more sensitive to PGON than PoPLR and linear regression of MD and VFI in our sample, while providing localized progression information.

Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma.

Faster visual field progression was associated with the occurrence of depressive symptoms in patients with glaucoma.

Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes.

Compared with healthy eyes, the mean rate of global rim area loss was 3.7 times faster and the mean rate of global percentage rim area loss was 5.4 times faster in progressing glaucoma eyes.

Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma.

Objective assessment of pupillary responses using a pupillometer was associated with asymmetric macular structural damage in patients with glaucoma.

The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.

Progressive decline in sensitivity in the central inferior area of the visual field had the strongest association with longitudinal decline in QoL of patients with glaucoma.

Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes.

The Spectralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good agreement for detection of eyes with early glaucoma damage.

Does the Location of Bruch's Membrane Opening Change Over Time? Longitudinal Analysis Using San Diego Automated Layer Segmentation Algorithm (SALSA).

Bruch's membrane opening location was stable in normal and progressing glaucoma eyes with follow-up between 3 and 4 years indicating that it can be used as reference point in monitoring glaucoma progression.

Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor.

Prostaglandin analogues, but not other medications, seem to flatten the IOP-related increase at transition of the wake/sitting to the sleep/supine period, but do not seem to have an effect on acrophase and amplitude.

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods.

Loss of RNFL thickness was seen in a substantial number of contralateral eyes of glaucoma patients showing unilateral progression by conventional methods.

Estimating Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects.

Assessment of RNFL thickness with OCT was able to detect glaucomatous damage before the appearance of visual field defects on SAP.

Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study.

SAP performed significantly better than FDT in predicting change in NEI VFQ-25 scores in our population, suggesting that it may still be the preferable perimetric technique for predicting risk of disability from the disease.

Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.

Each copy of the T risk allele has an additive effect and was associated with thinner global and sectoral RNFL. Findings from this QTL analysis further support a genetic contribution to glaucoma pathophysiology.

Evaluation of Postural Control in Patients with Glaucoma Using a Virtual Reality Environment.

The study presented and validated a novel paradigm for evaluation of balance control in patients with glaucoma on the basis of the assessment of postural reactivity to dynamic visual stimuli using a virtual reality environment.

Biomarkers and surrogate endpoints in glaucoma clinical trials.

The use of composite endpoints in glaucoma trials may overcome weaknesses of the use of structural or functional endpoints in isolation.

Relationship Between Motor Vehicle Collisions and Results of Perimetry, Useful Field of View, and Driving Simulation in Drivers With Glaucoma.

Reaction times to low contrast divided attention tasks during driving simulation were significantly associated with history of MVC, performing better than conventional perimetric tests and UFOV.

The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects.

In this cohort of glaucoma suspects with similar access to treatment, multivariate analysis revealed that at higher mean IOP during follow-up, individuals of African descent were more likely to develop VF damage than individuals of…

Association between progressive retinal nerve fiber layer loss and longitudinal change in quality of life in glaucoma.

Progressive binocular RNFL thickness loss was associated with longitudinal loss in quality of life, even after adjustment for progressive visual field loss.

Longitudinal changes in quality of life and rates of progressive visual field loss in glaucoma patients.

Baseline severity, magnitude, and rates of change in BVF sensitivity were associated with longitudinal changes in QoL of glaucoma patients.

Analysis of 24-Hour IOP-related Pattern Changes After Medical Therapy.

Response to comment on the article entitled "effect of improper scan alignment on retinal nerve fiber layer thickness measurements using stratus optical coherence tomograph" by Vizzeri G, et al published in J Glaucoma. 2008;17: 341-349.

Diagnostic ability of retinal nerve fiber layer imaging by swept-source optical coherence tomography in glaucoma.

Swept-source OCT wide-angle and peripapillary RNFL thickness measurements performed well for detecting glaucomatous damage. The diagnostic accuracies of the swept-source OCT and spectral-domain OCT RNFL imaging protocols evaluated in this study were similar.