Quantitative analysis of dynamic iris changes in primary angle-closure disease with long axial lengths: the Handan Eye Study.
Wang Jin, Wang Yue, Zhang Qing, Li Si Zhen, He Ming Guang, Wang Ningli, Zhang Ye
AI Summary
This study found that dynamic and static iris parameters are consistent across primary angle-closure disease patients, regardless of axial length, suggesting these factors contribute to angle closure even in atypical cases.
Abstract
Objective
To investigate dynamic iris changes in patients with primary angle-closure disease (PACD) with long axial length (AL) compared to those with short and medium AL.
Methods
This observational cross-sectional study enrolled participants aged 35 years or older from the Handan Eye Study follow-up examination who were diagnosed with PACD and underwent Visante anterior segment optical coherence tomography (ASOCT) imaging under light and dark conditions. The right eye of each participant was included in the analysis. AL was categorized as short (<22.0 mm), medium (≥22.0 to ≤23.5 mm), or long (>23.5 mm). Anterior segment parameters, including iris dynamic changes, were compared among the three groups with different ALs.
Results
Data from 448 patients with PACD were analyzed. We found that 10.9% of included eyes had a long AL with a flatter cornea; larger central anterior chamber depth, angle opening distance, anterior chamber width, anterior chamber area, and volume; and smaller lens thickness and lens vault (LV) (P < 0.05) than those with short AL. No significant difference existed between the three groups in iris thickness, iris cross-sectional area (IA), iris curvature, or pupil diameter (PD) change between light and dark (P > 0.05). The significant associated factors for IA changes were area recess area (ARA) in the dark, LV in the dark, and PD change from light to dark (P < 0.05).
Conclusions
Dynamic and static iris parameters were consistent across patients with PACD with short, medium, or long AL and may contribute to the pathogenesis of angle closure in atypical PACD.
MeSH Terms
Shields Classification
Key Concepts4
In patients with primary angle-closure disease (PACD) with long axial length (>23.5 mm), 10.9% of included eyes had a flatter cornea, larger central anterior chamber depth, angle opening distance, anterior chamber width, anterior chamber area, and volume, and smaller lens thickness and lens vault (LV) (P < 0.05) compared to those with short axial length (<22.0 mm).
No significant difference was found between the three groups of primary angle-closure disease (PACD) patients with short (<22.0 mm), medium (≥22.0 to ≤23.5 mm), or long (>23.5 mm) axial lengths in iris thickness, iris cross-sectional area (IA), iris curvature, or pupil diameter (PD) change between light and dark conditions (P > 0.05).
The significant associated factors for iris cross-sectional area (IA) changes in primary angle-closure disease (PACD) patients were area recess area (ARA) in the dark, lens vault (LV) in the dark, and pupil diameter (PD) change from light to dark (P < 0.05).
Dynamic and static iris parameters were consistent across patients with primary angle-closure disease (PACD) with short (<22.0 mm), medium (≥22.0 to ≤23.5 mm), or long (>23.5 mm) axial length, suggesting they may contribute to the pathogenesis of angle closure in atypical PACD.
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